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1821 articles
September 202624
A phase 1/1b study of the all-oral regimen CC-486 and venetoclax in acute myeloid leukemia.
This phase 1/1b study evaluated the all-oral regimen of CC-486 and venetoclax in patients with relapsed, refractory, and newly diagnosed acute myeloid leukemia (AML).
A phase 1b/2 study of ceralasertib, a selective inhibitor of ATR, in patients with relapsed or refractory MDS and CMML.
This phase 1b/2 study evaluated ceralasertib, an ATR inhibitor, in 44 adults with relapsed or refractory MDS and CMML. The overall response rate was 29.5%, with a median progression-free survival of 4.8 months and…
Clinical, economic, and quality-of-life outcomes of brexucabtagene autoleucel for the treatment of relapsed/refractory mantle cell lymphoma and B-cell acute lymphoblastic leukemia: A systematic literature review and meta-analysis.
This systematic literature review and meta-analysis evaluated the clinical, healthcare resource use, and quality-of-life outcomes of brexucabtagene autoleucel in adults with relapsed/refractory mantle cell lymphoma…
Metastasis of Invasive Ductal Carcinoma of the Breast to the Uterine Cervix 30 Years Post-Mastectomy: A Case Report.
A 69-year-old woman, 30 years post-mastectomy for invasive ductal carcinoma, presented with abnormal cervical cytology. Imaging revealed a 38-mm cervical mass, leading to a modified radical hysterectomy.
First systematic mapping of non-target [68Ga]Ga-DOTANOC uptake across anatomical sites and etiologies.
This systematic review analyzed 76 studies involving 542 patients to map non-target [68Ga]Ga-DOTANOC uptake across various anatomical sites and etiologies.
Metastatic melanoma presenting with paraneoplastic dermatomyositis mimicking polymyalgia rheumatica.
A man in his late 70s presented with bilateral shoulder and hip girdle pain, morning stiffness, and significant weight loss over six weeks.
POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder and skin changes) associated with Castleman disease and latent tuberculosis: a diagnostic challenge.
A woman in her 40s presented with progressive multisystem disease, including chronic distal neuropathy, constitutional decline, lymphadenopathy, and serosal effusions.
Metastatic muscle invasive bladder cancer in pregnancy.
A woman in her 30s presented during the second trimester with hematuria and left flank pain. MRI identified a T3b bladder tumor with suspected peritoneal invasion.
Implementing a medical opinion leader-led management model to promote timely treatment initiation among screen-positive patients with upper gastrointestinal cancer in rural China: a cluster randomised controlled trial protocol.
This cluster randomised controlled trial aims to assess the effectiveness of a medical opinion leader-led management model in reducing treatment initiation time for screen-positive upper gastrointestinal cancer patients…
The oral und systemic health risks of sugar consumption: an umbrella review.
This umbrella review analyzed systematic reviews to assess the health risks associated with free sugar consumption, focusing on both oral and systemic health.
Comparative Effectiveness and Safety of FOLFOXIRI Plus Cetuximab Versus FOLFOXIRI Plus Bevacizumab in Metastatic Colorectal Cancer: A GRADE-assessed Systematic Review and Meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness and safety of FOLFOXIRI plus cetuximab versus FOLFOXIRI plus bevacizumab in 561 patients with metastatic colorectal cancer (mCRC).
Cardiac intimal sarcoma presenting with pseudo-pulmonary embolism: surgical debulking, RVOT reconstruction and pulmonary valve replacement.
A 27-year-old woman presented with dyspnoea and signs of right-heart failure following delivery. Initial imaging suggested pulmonary embolism, prompting emergency surgery due to haemodynamic instability.
Coffee consumption and head and neck cancer risk: a dose-response and site-specific meta-analysis.
This meta-analysis examined the relationship between coffee consumption and head and neck cancer (HNC) risk across 30 studies.
Hypofractionated versus conventional fractionated postmastectomy radiotherapy for patients with high-risk breast cancer (CHN HYPOPMRT): 10-year outcomes from a randomised, non-inferiority, open-label, phase 3 trial.
This phase 3 randomized trial compared hypofractionated (43.5 Gy in 15 fractions) and conventional (50 Gy in 25 fractions) postmastectomy radiotherapy in 810 women with high-risk breast cancer.
Prophylactic Immediate Lymphatic Reconstruction for the Prevention of Secondary Lymphedema: A Systematic Review and Meta-Analysis of Comparative Studies.
This systematic review and meta-analysis evaluated the effectiveness of prophylactic lymphovenous shunting (LVS) in preventing secondary lymphedema in 2261 patients undergoing axillary and inguinal lymph node…
Unveiling the Prognostic Power of Circulating Tumor DNA in Multiple Myeloma: A Systematic Review and Updated Meta-Analysis.
This systematic review and meta-analysis evaluated the prognostic significance of circulating tumor DNA (ctDNA) in 948 patients with multiple myeloma (MM).
The Effect of Emotional Freedom Techniques on Death Anxiety and Cancer-Related Anxiety in Patients Undergoing Oncological Surgery: A Randomized Controlled Trial.
This randomized controlled trial examined the impact of emotional freedom techniques (EFT) on death anxiety and cancer-related anxiety in 120 patients undergoing oncological surgery.
Uveitis as a class effect of Bruton tyrosine kinase inhibitors: ibrutinib and zanubrutinib ocular toxicity.
A man in his early 50s with Waldenström macroglobulinaemia developed posterior uveitis while on ibrutinib, characterized by vitreous and retinal infiltrates.
Combined mastectomy and beating heart coronary artery bypass grafting: a single-session surgical approach.
A woman in her 70s with papillary ductal carcinoma in situ underwent a combined surgical approach due to severe coronary artery disease.
Efficacy and safety of T-DXd versus Other HER2-targeted therapies in second-line and later settings for HER2-positive metastatic breast cancer: A Bayesian network meta-analysis.
This Bayesian network meta-analysis evaluated the efficacy and safety of T-DXd compared to other HER2-targeted therapies in 3,339 patients with HER2-positive metastatic breast cancer after trastuzumab-based therapy.
Time toxicity in cancer care: a systematic review of definitions and measurement methods.
This systematic review examined the definitions and measurement methods of time toxicity in cancer care, involving 56 studies primarily from high-income countries.
Heart rate variability suppression in cancer patients versus non-cancer controls: a systematic review and meta-analysis.
This systematic review and meta-analysis examined heart rate variability (HRV) in cancer patients compared to non-cancer controls, including 28 studies with 3232 participants.
Segmental sternal resection for metastatic ovarian cancer: surgical technique and clinical outcome.
Isolated sternal recurrence from ovarian cancer is exceptionally rare, and its optimal surgical management remains poorly defined.
Home-based exercise interventions incorporating cardiac rehabilitation principles for people with cancer: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated home-based exercise interventions incorporating cardiac rehabilitation principles in adults with cancer.
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