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1316 articles
October 202624
Acute management of pelvic ring injuries: identifying common treatment principles across institutional algorithms.
This PRISMA-guided systematic review compared published institutional algorithms for acute pelvic ring injury management. Searches identified 25 studies describing algorithms, pathways, or protocols published from 2006…
Amygdala neurofeedback as an adjunct to residential dialectical behavior therapy for borderline personality disorder: a pilot randomized controlled trial.
This pilot randomized controlled trial tested whether real-time fMRI amygdala neurofeedback (amy-NF) adds benefit to residential dialectical behavior therapy (DBT) for people with borderline personality disorder and…
Recruitment, Engagement, Experiences, and Self-Reported Changes in a Digital Patient Activation Intervention to Improve Hemodialysis Session Stability: Mixed Methods Study.
This mixed methods study evaluated recruitment, engagement, completion, and participant experiences in Dialysafe, a digital education and peer-mentoring intervention at 10 hemodialysis centers.
Short-term Rhodiola rosea supplementation improves premenstrual symptoms, reaction time, and perceived exertion in female taekwondo athletes: a randomised double-blind placebo-controlled trial.
This randomised, double-blind, placebo-controlled trial tested 10 days of Rhodiola rosea (RR) supplementation during the estimated symptomatic premenstrual phase in 24 female taekwondo athletes with moderate-to-severe…
Umbrella review of low-level light therapy: evidence across clinical conditions.
This umbrella review synthesized systematic reviews and meta-analyses of low-level light therapy (LLLT) in humans across clinical conditions. It included 100 reviews, covering 790 unique primary studies.
Multicenter Phase I Study of Triapine in Combination with [177Lu]Lutetium-Dotatate in Patients with Well-Differentiated Neuroendocrine Tumors (ETCTN 10388).
This multicenter phase I dose-escalation and dose-expansion study evaluated [177Lu]lutetium-dotatate plus oral triapine in patients with well-differentiated gastroenteropancreatic neuroendocrine tumors.
Long-term Results of Multiantigen Stimulated Cell Therapy I, Alone or in Combination with Chemotherapy, as First-line Maintenance Therapy in Advanced Sarcoma: A Multicenter, Phase I Trial.
This multicenter, phase I trial evaluated multiantigen stimulated cell therapy I (MASCT-I), alone or with ifosfamide, as first-line maintenance therapy in 31 patients with advanced sarcoma whose disease was controlled…
Feasibility and Activity of Concurrent Neoadjuvant Chemotherapy and Radiotherapy in Patients with High-risk Soft-Tissue Sarcoma.
This analysis of the international, randomized phase III ISG-STS 1001 trial assessed concurrent epirubicin–ifosfamide chemotherapy (EI) and radiotherapy in patients with localized, high-risk soft-tissue sarcoma.
The Moderating Effects of Race and Ethnicity on a Motivational Interviewing Intervention for Improving Physical Health Among Patients With Peripheral Artery Disease: Secondary Analysis of a Pilot Randomized Trial.
This secondary analysis of a pilot randomized trial examined whether social determinants of health modified motivational interviewing (MI) effects on walking distance and weight among community-dwelling adults with…
AI-Enabled Telerehabilitation for Chronic Nonspecific Neck Pain: Multicenter Randomized Controlled Trial.
This multicenter, prospective, parallel-group randomized noninferiority trial compared AI-enabled home telerehabilitation with exercise-matched outpatient rehabilitation in people with chronic nonspecific neck pain…
AI-Based Pathology Classifier Predicts Sensitivity to Enzalutamide in Metastatic Hormone-Sensitive Prostate Cancer: A Biomarker Analysis of the ENZAMET Trial.
This prespecified biomarker analysis of the randomised ENZAMET trial assessed whether a locked artificial intelligence pathology image classifier (APIC) identified differential overall-survival benefit from enzalutamide…
The effects of sodium reduction and the DASH diet on ambulatory blood pressure: overall and race-stratified results from the DASH-Sodium trial.
This randomized feeding trial examined ambulatory blood pressure (ABP) responses to sodium reduction and the DASH diet in 335 participants, 58% of whom self-identified as Black.
Predicting neurodevelopmental delay among two-year-old infants in Northern Uganda.
This study developed and evaluated a risk-prediction model for neurodevelopmental delay among two-year-old children in Northern Uganda.
Optimizing Autologous Fat Grafting: A Systematic Review of Enhancement Strategies and Graft Survival.
This systematic review assessed strategies for enriching autologous fat grafts to improve graft survival, drawing on animal and clinical studies published through February 2025.
Prognostic value of measuring LSC frequency in AML: a systematic review and meta-analysis.
This systematic review and reconstructed individual patient data meta-analysis assessed whether leukemia stem cell (LSC) measurements predict outcomes in patients with acute myeloid leukemia at diagnosis or in…
Phase II Trial of First-line Axitinib plus Nivolumab in Patients with Advanced Mucosal Melanoma.
This single-center, investigator-initiated phase II trial evaluated first-line nivolumab plus axitinib in patients with untreated unresectable or metastatic mucosal melanoma.
Blood-based biomarkers in patients with recurrent, persistent, or metastatic endometrial cancer treated with olaparib and cediranib: Results from NRG-GY012.
This biomarker analysis of the phase 2 NRG-GY012 clinical trial assessed blood-based markers and outcomes among patients with recurrent, persistent, or metastatic endometrial cancer treated with olaparib, cediranib, or…
Geographic Variation in Diagnostic Performance of Amsel Criteria and Nugent Score for Vaginal Dysbiosis Defined by 16S rRNA Gene Sequencing.
This analysis compared Amsel criteria and Nugent scoring with 16S rRNA sequencing-defined vaginal community state types in screening and follow-up specimens from a Phase 1b randomized trial at sites in South Africa and…
Comparative Efficacy and Safety of Systemic Immunomodulatory Therapies for Non-Infectious Uveitis: A Systematic Review With Pairwise and Network Meta-Analyses.
This systematic review and network meta-analysis compared systemic immunomodulatory therapies for non-infectious uveitis (NIU), including evidence from seven studies with 992 participants: six randomised trials and one…
Body weight following a multidomain lifestyle intervention in older adults at risk of dementia - A post-hoc analysis of the AgeWell.de-trial.
This post-hoc analysis of the cluster-randomized AgeWell.de trial examined body weight in 678 adults aged 60–77 years with overweight or obesity and at risk for dementia.
Immunogenicity of a Bivalent Typhoid-Paratyphoid Conjugate Vaccine Against Diverse Salmonella Paratyphi A Isolates.
This exploratory analysis of a phase 1 randomised controlled trial assessed O:2-specific IgA and IgM responses and serum bactericidal activity after two doses of a bivalent typhoid-paratyphoid conjugate vaccine.
FDA Approval Summary: Erdafitinib for FGFR3-Altered Locally Advanced or Metastatic Urothelial Carcinoma.
This FDA approval summary describes evidence supporting erdafitinib for patients with FGFR3-altered locally advanced or metastatic urothelial carcinoma that progressed during or after at least one systemic therapy.
A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02.
BilT-02 was a multicenter phase II trial of rucaparib plus nivolumab as maintenance therapy for patients with advanced biliary tract cancer whose disease had not progressed after 4 to 6 months of first-line…
Circulating Thymidine Kinase Activity Predicts Survival and Optimal Treatment Sequencing in BRAF-Mutated Metastatic Melanoma in the SECOMBIT Trial.
This randomized phase II trial biomarker analysis evaluated circulating thymidine kinase activity (TKa) in patients with BRAF V600-mutated metastatic melanoma receiving targeted therapy (TT), immune checkpoint…
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