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1821 articles
September 202624
Bilateral Vortex Keratopathy in a Patient Receiving Long-Term Ribociclib Therapy.
A 67-year-old woman with metastatic breast cancer was found on routine eye examination to have bilateral whorl-like corneal epithelial deposits after four years of continuous ribociclib therapy.
Prolonged survival after systemic immune reactivation by aglatimagene besadenovec plus valacyclovir in immune checkpoint inhibitor-refractory non-small cell lung cancer.
This phase 2a clinical trial evaluated the combination of aglatimagene besadenovec and valacyclovir in 76 patients with immune checkpoint inhibitor-refractory non-small cell lung cancer.
Abemaciclib and lenalidomide presenting with central retinal artery occlusion in a patient with breast cancer and multiple myeloma: a possible treatment-related association.
A woman in her late seventies with metastatic hormone receptor-positive breast cancer and multiple myeloma experienced sudden, painless vision loss in her right eye while on long-term abemaciclib and lenalidomide.
Primary adrenal lymphoma presenting as primary adrenal insufficiency.
A man in his late 60s presented with symptoms of adrenal failure, including anaemia and hypercalcaemia. Initial tests indicated adrenal insufficiency, and imaging showed bilateral adrenal enlargement.
Metastatic dedifferentiated malignant melanoma with spindle cell morphology.
A man in his early 60s presented with a slow-growing skin lesion on his back, which had been present for two decades, and a newly noticed right axillary mass.
Circulating tumour DNA and its clinical relevance in predicting progression-free survival and overall survival in patients with advanced breast cancer: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the prognostic value of circulating tumour DNA (ctDNA) in predicting progression-free survival (PFS) and overall survival (OS) in patients with advanced breast cancer…
Second-Line Systemic Therapy Following First-Line FOLFIRINOX or NALIRIFOX in Metastatic Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated second-line therapies following first-line FOLFIRINOX or NALIRIFOX in 3888 adults with metastatic pancreatic ductal adenocarcinoma.
Sacituzumab tirumotecan in previously treated metastatic triple-negative breast cancer: a detailed safety analysis of the randomized OptiTROP-Breast01 study.
This randomized controlled trial analyzed the safety profile of sacituzumab tirumotecan (sac-TMT) in 262 patients with previously treated metastatic triple-negative breast cancer.
Population Pharmacokinetics and Exposure-response Analysis of Durvalumab in Patients with Limited-stage Small-cell Lung Cancer in the Phase 3 ADRIATIC Study.
The ADRIATIC study evaluated the population pharmacokinetics and exposure-response relationships of durvalumab in patients with limited-stage small-cell lung cancer (LS-SCLC).
A comparison of the efficacy of cognitive-behavioral stress management and acceptance and commitment therapy on the quality of life and fatigue of caregivers of patients with cancer: a randomized controlled trial.
This randomized controlled trial compared the efficacy of cognitive behavioral stress management (CBSM) and acceptance and commitment therapy (ACT) on the quality of life and fatigue in 66 caregivers of cancer patients.
Systemic and intracranial activity of antibody-drug conjugates in patients with non-small cell lung cancer and brain metastases: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed systemic and intracranial responses to antibody-drug conjugates (ADCs) in patients with non-small cell lung cancer and brain metastases.
External validation of the NADIR model for early prostate-specific antigen response prediction in enzalutamide-treated metastatic hormone-sensitive prostate cancer: An analysis of the ARCHES trial.
This validation study assessed the NADIR model's ability to predict early prostate-specific antigen (PSA) response in 558 enzalutamide-treated patients from the ARCHES trial.
Mindful eating as a supportive intervention for breast cancer survivors: a pilot randomized controlled trial.
This pilot randomized controlled trial assessed whether a six-session mindful eating intervention added to treatment-as-usual (TAU) improved eating behaviors and body composition in breast cancer survivors.
Molecular biomarkers as key determinants of outcome in mantle cell lymphoma: results from the FIL V-RBAC trial.
This phase II clinical trial analyzed the molecular landscape of 132 older patients with mantle cell lymphoma (MCL) from the FIL V-RBAC trial.
Carfilzomib plus induction chemotherapy for children with relapsed or refractory acute lymphoblastic leukemia.
This phase II clinical trial evaluated the efficacy of carfilzomib combined with induction chemotherapy (CFZ-VXLD) in pediatric patients aged 1 month to <21 years with relapsed or refractory acute lymphoblastic leukemia…
Mucinous Adenocarcinoma Arising in a Mature Ovarian Teratoma.
A woman in her 30s presented with a 19 cm right ovarian mass. She underwent extensive surgical intervention, including right salpingo-oophorectomy and lymphadenectomy.
Resolution of Phlegmasia Cerulea Dolens in a Patient with Metastatic Cancer and an Inferior Vena Cava Filter.
A 69-year-old man with metastatic non-small cell lung cancer developed rapidly progressive phlegmasia cerulea dolens despite recent negative imaging and an inferior vena cava filter.
Primary ALK-positive anaplastic large cell lymphoma of the urinary bladder in a pediatric patient: a case report and review of literature.
A 14-year-old male presented with several months of gross hematuria that became painful. Imaging revealed a mass-like thickening of the anterior bladder wall, and cystoscopy identified a 3.5-cm pedunculated lesion.
Concurrent follicular lymphoma and follicular dendritic cell sarcoma: composite neoplasm or transdifferentiation?
A 52-year-old woman presented with night sweats, weight loss, and an obstructing colonic mass with mesenteric disease. Biopsy revealed two distinct tumor populations: one consistent with follicular large B cell lymphoma…
Virtual reality as a non-pharmacological adjuvant for anxiety in oncology care: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness of virtual reality (VR) interventions for managing anxiety in cancer patients.
Long-term outcome after partial breast irradiation with interstitial multi-catheter high-dose-rate brachytherapy: Results from a Phase II prospective study with extended follow-up.
This prospective observational Phase II study assessed late toxicity, cosmesis, and cancer outcomes after partial breast irradiation with interstitial multi-catheter high-dose-rate brachytherapy.
Sarcopenia Is Associated With Severe Treatment Toxicity and Mortality in Older Adults With Advanced Cancer: A Secondary Analysis.
This secondary analysis of a randomized controlled trial examined the impact of sarcopenia on treatment outcomes in 161 older adults (≥ 70 years) with advanced cancer.
Progression-free survival and objective response rate as a surrogate end point for overall survival in metastatic renal cell carcinoma: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the validity of progression-free survival (PFS) and objective response rate (ORR) as surrogate endpoints for overall survival (OS) in randomized controlled trials of…
Contrast-Enhanced Ultrasound Evaluation of Papillary Renal Cell Carcinoma.
A patient with papillary renal cell carcinoma (RCC) presented with an indeterminate renal lesion. Contrast-enhanced ultrasound (CEUS) was utilized to assess the vascularity of the lesion, revealing distinct patterns of…
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