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1316 articles
October 202624
Uniportal versus Multiportal Video-Assisted Thoracoscopic Surgery for Minimally Invasive Esophagectomy in Esophageal Cancer: A GRADE-Assessed Systematic Review and Meta-Analysis.
This GRADE-assessed systematic review and meta-analysis compared uniportal (uVATS) with multiportal video-assisted thoracoscopic surgery (mVATS) for minimally invasive esophagectomy in adults with esophageal cancer.
AI-Driven Lifestyle Interventions for Reducing Diabetes Risk: Systematic Review.
This systematic review assessed AI-driven digital lifestyle interventions for people with prediabetes or elevated diabetes risk, including healthy participants in feasibility studies.
A Systematic Review of Screen Time and Obesity in Children, Adolescents, and Young Adults: Sex-Specific Pathways and Implications for Public Health Interventions.
This systematic review synthesized evidence on screen time and obesity-related outcomes in children, adolescents, and young adults, examining possible sex-specific patterns.
Immune checkpoint inhibitor-related myocarditis, myositis, and myasthenia gravis overlap syndrome: a single-center case series and systematic review.
The aim of our study was to evaluate the clinical, diagnostic, therapeutic, and prognostic features of immune checkpoint inhibitor-related myocarditis, myositis, and myasthenia gravis overlap syndrome (IM3OS).
Conservative Outcomes of Subtalar Dislocation: A Systematic Review and Meta-Analysis of the Current Literature.
This systematic review and meta-analysis assessed outcomes after closed reduction and immobilisation of acute isolated subtalar dislocations.
Association of immune checkpoint-related polymorphisms in PD-1, PD-L1, and CTLA-4 genes with susceptibility to genitourinary cancer: a meta-analysis.
This meta-analysis pooled evidence from 16 case-control studies examining six single-nucleotide polymorphisms in PD-1, PD-L1, and CTLA-4 genes and susceptibility to genitourinary cancers, including urothelial, renal…
Bacterial infections and antibiotic susceptibility in children with sickle-cell anemia on malaria chemoprevention using Dihydroartemisinin-piperaquine (DP) or Sulfadoxine-pyrimethamine (SP) in Uganda.
This analysis nested within a randomized, double-blind trial assessed bacterial infections and antimicrobial resistance among Ugandan children aged 6 months to 15 years with sickle-cell anemia receiving weekly…
Long-Acting HIV Therapy in African Adults with Adherence Challenges.
This phase 3b, open-label, randomized trial compared long-acting injectable cabotegravir plus rilpivirine with daily oral dolutegravir-based therapy in adults in Kenya, South Africa, and Uganda who had suppressed HIV-1…
Global Underutilization of Antiviral Therapy and Survival Outcomes in Hepatitis B Virus-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of 78 Studies and 68,243 Patients.
This systematic review and meta-analysis assessed antiviral use and its association with survival and hepatocellular carcinoma (HCC) recurrence in adults with HBV-related HCC.
Evidence on Glutathione and Boosters for Prevention of Chemotherapy-Induced Neuropathy: A Systematic Review and Network Meta-Analysis.
This systematic review and network meta-analysis compared glutathione (GSH) and GSH boosters for preventing chemotherapy-induced peripheral neuropathy (CIPN), drawing on 25 randomised controlled trials involving 1625…
Efficacy of Stromal Vascular Fraction for Scar Prevention: A Multicenter, Double-Blinded, Randomized Controlled Trial.
This multicenter, double-blinded, placebo-controlled randomized trial evaluated intraoperative stromal vascular fraction (SVF) injections for scar prevention in 45 patients undergoing free tissue transfer at three…
Dynamics of QuantiFERON-TB Gold Plus Results in a Large TB Preventive Treatment Trial Across 3 High-Burden HIV/TB Countries.
This longitudinal analysis of a randomized trial assessed serial QuantiFERON-TB Gold Plus (QFT-Plus) results in people with HIV enrolled in Ethiopia, Mozambique, and South Africa and assigned to three TB preventive…
Efficacy and safety of baxdrostat in the management of uncontrolled hypertension: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed baxdrostat versus placebo in randomized controlled trials involving patients with uncontrolled hypertension.
A Prospective, Multicenter, Evaluator-Blind, Randomized, Comparator-Controlled Study of Belotero Intense (+), a Hyaluronic Acid Filler With Lidocaine, for Lip Augmentation.
This multicenter, evaluator-blind randomized comparator-controlled equivalence trial assessed Belotero Intense with lidocaine (BIL) for lip augmentation in patients with lip volume deficits, comparing it with Restylane…
Multimodal assessment of exceptional responders refines subtyping-directed precision treatment in HR+/HER2- breast cancer.
This clinical-trial analysis examined whether multimodal tumour and clinical features could clarify exceptional responses to subtype-directed treatment in locally advanced HR+/HER2− breast cancer.
Psychoeducational interventions for children and adolescents with potentially traumatic experiences: a systematic review.
This systematic review examined stand-alone psychoeducational interventions for children and adolescents exposed to potentially traumatic experiences, including interventions delivered directly or through caregivers.
Symptom improvement with dosing above 9 g of low-sodium oxybate: effectiveness and safety in participants with narcolepsy in the DUET study.
This prospective, multicohort, open-label study evaluated effectiveness and safety of low-sodium oxybate (LXB) doses above 9 g/night in participants with narcolepsy type 1 or 2 who were already taking 9 g/night.
Phase 2 Trial of Icotrokinra for Patients with Ulcerative Colitis.
This phase 2b, double-blind, randomized trial evaluated once-daily oral icotrokinra, an interleukin-23 receptor blocker, in adults with moderately to severely active ulcerative colitis.
Primary Hepatic Neuroendocrine Neoplasms: Systematic Review and Expert Pathologist Reappraisal Using the WHO 6th Edition Framework.
Primary hepatic neuroendocrine neoplasms (PHNENs) are exceedingly rare. Published evidence often lacks adequate clinicopathological support for a primary hepatic origin and uses inconsistent historical terminology.
Ponatinib-Blinatumomab or Imatinib-Chemotherapy for Adult Ph-Positive ALL.
This multicenter, phase 3 randomized trial compared frontline ponatinib plus blinatumomab with imatinib plus chemotherapy in adults with Philadelphia-positive acute lymphoblastic leukemia.
Modulation of the gut microbiome and resistome by antibiotic use, but not by subsequent 2'-fucosyllactose intake, in adults with overweight or obesity.
This randomized, double-blind, placebo-controlled intervention examined gut microbiome and resistome changes in 18 adults with overweight or obesity after seven days of vancomycin, followed by eight weeks of…
Brigimadlin versus Doxorubicin in Advanced Dedifferentiated Liposarcoma: Efficacy, Safety, and Translational Data from Brightline-1, a Randomized Phase II/III Trial.
Brightline-1 was a randomized phase II/III trial comparing first-line brigimadlin with doxorubicin in patients with MDM2-amplified, locally advanced or metastatic dedifferentiated liposarcoma.
Artificial intelligence EEG biomarkers for schizophrenia diagnosis: Systematic review with PROBAST+AI assessment.
This systematic review assessed the diagnostic performance and methodological quality of AI models using resting-state EEG to identify schizophrenia or first-episode psychosis.
A Phase I Dose-Escalation/Expansion Study of Fractionated-Dose and Multiple-Cycle Anti-PSMA-Targeted α-Emitter 225Ac-J591 in Patients with Prostate Cancer.
This phase I dose-escalation and expansion study evaluated fractionated and repeated-cycle 225Ac-J591 in patients with progressive metastatic prostate cancer resistant to androgen pathway modulation.
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