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497 articles
August 202622
Transperitoneal Laparoscopic Adrenalectomy for Schwannoma with Severe Renal Vein Adhesion.
A 66-year-old man had an asymptomatic renal hilar mass found on surveillance ultrasound. CT showed a 5-cm irregular soft-tissue mass encasing the hilar vessels and two renal arteries arising from the aorta behind the…
Identification and characterisation of a novel homozygous KDM5A variant associated with severe axial hypotonia, seizures, and cardiac anomalies.
A patient with severe neurodevelopmental delay had neuromotor delay, profound axial hypotonia with absent head control, mild upper-limb spasticity, a history of seizures, facial dysmorphism and congenital heart disease.
Pediatric Gastric GIST With SDHA Truncation Despite Retained SDHB Staining: A Case Report.
A 14-year-old boy presented with a gastric GIST, which was positive for KIT and DOG1. Genetic analysis revealed a truncating variant in the SDHA gene, indicating SDH deficiency.
Efficacy of Luseogliflozin Added to Semaglutide in Patients With Metabolic Dysfunction-Associated Steatohepatitis and Type 2 Diabetes Mellitus: A Randomised, Open-Label Trial.
This 52-week, open-label, randomised, parallel-group trial in Japan compared luseogliflozin plus semaglutide with semaglutide alone in adults with biopsy-proven MASH and type 2 diabetes.
Artificial intelligence for predicting BCG response in non-muscle-invasive bladder cancer: a systematic review.
This systematic review assessed artificial intelligence and machine-learning models predicting outcomes after intravesical BCG for non-muscle-invasive bladder cancer.
Neoadjuvant Immunotherapy in Localized dMMR/MSI-H Colon Cancer: A Systematic Review of Pathological Response and Surgical Outcomes.
This systematic review assessed prospective interventional studies of neoadjuvant immune checkpoint inhibition in adults with localized, non-metastatic dMMR/MSI-H colon cancer. Six studies were included.
Twelve-Year Follow-up of a Family With CKD Caused by an mtDNA Variant.
Five siblings with unaffected parents presented with hyperuricemia and chronic kidney disease; the proband died of end-stage kidney disease at age 16.
FDG PET/CT in a Case of Urothelial Carcinoma Arising From a Functional Renal Allograft.
Nine years after renal transplantation, a patient with a functional renal allograft was found to have high-grade urothelial carcinoma arising within the graft, with lymph node metastases.
Fatal pulmonary thromboembolism associated with excessive nitrous oxide consumption over several weeks.
A man in his early twenties was hospitalized with acute nitrous oxide intoxication, vitamin B12 deficiency and anaemia. Two weeks later, he was found dead; empty nitrous oxide cartridges were present, and his mother…
Diagnostic Accuracy of Soft Tissue Cytology and Risk of Malignancy Across the IAC-IARC-WHO Six-Tier Reporting System: A Systematic Review and Meta-Analysis With Retrospective Category Mapping.
This systematic review and meta-analysis evaluated the diagnostic accuracy of soft tissue cytology using the IAC-IARC-WHO six-tier reporting system.
Photo Quiz: Globose Yeast-Like Forms With Multiple Peripheral Buds in Urine and Cervical Cytology.
A 26-year-old immunocompetent woman with a history of low-grade papillary urothelial carcinoma presented with upper abdominal pain.
Analytically accurate, clinically inaccurate: A diagnostic case of Pseudohyperparathyroidism.
A 33-year-old kidney transplant recipient with prior secondary hyperparathyroidism treated by parathyroidectomy had a PTH result above the assay’s analytical measurement range, despite normal serum calcium and…
Enlarging Bilateral Perinephric Masses in Nephrotic Syndrome.
A 62-year-old man with biopsy-proven focal segmental glomerulosclerosis presented with nephrotic syndrome and enlarging bilateral perinephric masses.
Multifocal primary hepatic epithelioid hemangioendothelioma: a case in which tumor biopsy was critical to prevent misdiagnosis.
An 82-year-old woman undergoing postoperative surveillance for bladder cancer was found to have multiple hepatic masses on contrast-enhanced CT.
Clinical Profile, Electrophysiology, and Short-Term Outcomes of Pediatric-Onset Autoimmune Nodopathy-A Case Series.
The report describes three children with autoimmune nodopathy associated with antibodies to neurofascin 140, alone or with neurofascin 186.
Diagnostic accuracy of nuclear STAT6 immunohistochemistry for solitary fibrous tumour: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the diagnostic accuracy of nuclear STAT6 immunohistochemistry for solitary fibrous tumours (SFT) across 23 studies involving 1216 SFT and 4715 comparators.
Cell Blocks and the Milan System for Reporting Salivary Gland Cytopathology: A Meta-Analysis.
This meta-analysis evaluated the distribution of Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) categories and their associated risks of malignancy (ROM) in salivary gland fine-needle aspirations…
Medico-legal aspects of fatal ricin poisoning: a systematic review of clinical manifestations, toxicological findings and autopsy results.
This PRISMA-guided systematic review synthesized original studies, case reports, and case series describing fatal or near-fatal human ricin exposure.
Assessing Graded Histological Regression as Basis for Treatment Modification after Neoadjuvant Therapy in LAGC: An Exploratory Phase II Study.
This prospective, single-centre, open-label, randomised phase II trial assessed whether graded histologic regression (GHR) below 50% could guide adjuvant chemotherapy modification in locally advanced gastric cancer…
Xanthogranulomatous epithelial tumour of the calcaneus in a 32-year-old female: a rare entity.
A 32-year-old woman presented with 10 months of heel pain. Imaging showed a lytic lesion in the calcaneus, with giant cell tumour of bone and solid aneurysmal bone cyst among the initial considerations.
Primary Cutaneous Anaplastic Large Cell Lymphoma in a Patient With Li Fraumeni Syndrome.
A 64-year-old man with Li-Fraumeni syndrome and a germline TP53 p.R196* mutation presented with a solitary ulcerated nodule on the left anterior thigh.
Molecular autopsy in unexplained sudden death: a systematic review and meta-analysis of ACMG-corrected diagnostic yield, genomic architecture, and family translation.
This PRISMA-based systematic review and random-effects meta-analysis assessed postmortem genetic testing in unexplained sudden death.
July 20262
Low-Grade and Intermediate-Grade Apocrine Intraductal Carcinoma Arising in a Nevus Sebaceous of Jadassohn.
A 93-year-old woman had low- and intermediate-grade apocrine intraductal carcinoma arising in a nevus sebaceous of Jadassohn.
Otopathology of Pediatric Acute Tuberculous Meningitis-Case Series.
This case series presents three temporal bones from infants who succumbed to acute tuberculous meningitis (TBM). Pathological examination revealed significant inner ear damage, including cochlear fibrosis, atrophy of…
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