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751 articles
August 20268
Concurrent training is associated with enhanced post-exercise ceramide clearance and fat oxidation capacity in individuals with type 2 diabetes following lifestyle intervention.
This randomized controlled trial examined the effects of concurrent training combined with a palaeolithic-type diet on lipid dynamics in individuals with type 2 diabetes.
Efficacy and safety of add-on topiramate vs. metformin on cardiometabolic profile in patients of schizophrenia on atypical antipsychotics with metabolic syndrome: an active-controlled, rater-blinded, parallel-design randomized controlled trial.
This randomized controlled trial compared the efficacy and safety of topiramate versus metformin in 60 patients with schizophrenia and metabolic syndrome.
Primary Hyperparathyroidism-Induced Acute Pancreatitis: Case Report and Systematic Review.
A 61-year-old man presented with acute pancreatitis and severe hypercalcemia, with total serum calcium of 3.54 μmol/L (14.16 mg/dL) and parathyroid hormone of 640.5 pg/mL.
Metabolic Stress Testing Reveals Persistent Lipid-Handling Dysfunction in Women With Polycystic Ovary Syndrome Despite Exercise Training.
This randomized controlled trial examined metabolic responses in 12 women with polycystic ovary syndrome (PCOS) and 10 controls under physiological stress before and after 8 weeks of exercise training.
Serum Copeptin Rises After Tolvaptan for Hyponatraemia, but Does Not Predict Risk of Rapid Sodium Rise: Pre-Specified Secondary Analysis of the TVFR Trial.
This study analyzed the effects of tolvaptan on serum copeptin levels in hospitalized patients with hyponatraemia, as part of a pre-specified secondary analysis of a randomized controlled trial.
Intensive glycemic control in adults aged 80 years and older: A randomized trial evaluating diabetes complications and competing mortality.
This randomized controlled trial evaluated the effects of intensive glycemic control on diabetes complications in adults aged 80 years and older.
Effect of a pharmacist-led mHealth app on adherence, quality of life, and glycaemic control in diabetes: A multicentre RCT.
This multicentre randomized controlled trial evaluated the impact of the CareAide® mHealth app on medication adherence, quality of life, and glycaemic control in 663 patients with type 2 diabetes.
Cost-Effectiveness of Radiofrequency Ablation for Benign Non-Functioning Thyroid Nodules: A Systematic Review.
This systematic review evaluated the cost-effectiveness of radiofrequency ablation (RFA) compared to surgery for benign non-functioning thyroid nodules.
July 202616
Complete Pachydermoperiostosis With Acromegaloid Phenotype: Characteristic 99m Tc-Methylene Diphosphonate (MDP) Skeletal Scintigraphy in a Rare Clinical Mimic of Acromegaly.
Pachydermoperiostosis (Touraine-Solente-Gole syndrome) is a rare disorder that can mimic acromegaly and should be considered a differential in patients with acromegaloid features.
Beyond Glycaemia: Fear of Hypoglycaemia, Cognition and Functional Mobility After Advanced Hybrid Closed-Loop Therapy in Older Adults With Type 1 Diabetes: A Prespecified Secondary Analysis of a Randomised, Single-Centre Study.
This randomized controlled trial evaluated the effects of advanced hybrid closed-loop (AHCL) therapy on psychological and functional outcomes in older adults (≥65 years) with type 1 diabetes.
A New Highly Concentrated Insulin Aspart AT278 (500 U/mL) Demonstrates Ultra-Rapid Pharmacokinetic and Pharmacodynamic Properties in Type 2 Diabetes Regardless of BMI.
This randomized controlled trial evaluated the pharmacokinetics and pharmacodynamics of a new concentrated insulin aspart formulation (AT278-U500) in 41 overweight and obese individuals with type 2 diabetes.
Efficacy and Safety of Bimagrumab in Adults With Obesity and Metabolic Dysfunction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis evaluated the efficacy and safety of bimagrumab in 268 adults with obesity and metabolic dysfunction.
Effect of Medications for Type 2 Diabetes on Cardiovascular Events and Mortality: A Comprehensive Pairwise and Network Meta-Analysis.
This network meta-analysis evaluated the impact of various type 2 diabetes medications on major adverse cardiovascular events (MACE) and all-cause mortality across 93 randomized controlled trials.
Rare subcutaneous metastases of papillary thyroid carcinoma revealed by 18 F-FDG PET/CT.
A 76-year-old woman with a history of papillary thyroid carcinoma (PTC) underwent multiple treatments, including thyroidectomy and radioactive iodine therapy.
Oral GLP-1RA TERN-601 for Adults With Obesity/Overweight: Placebo-Controlled, Multiple-Ascending-Dose, Phase 1 and 2 Studies.
This study evaluated the safety, tolerability, pharmacokinetics, and efficacy of TERN-601, an oral GLP-1 receptor agonist, in adults with obesity or overweight through Phase 1 and 2 randomized controlled trials.
Hypophosphataemia following iron infusion: a narrative review of an increasingly recognised complication.
This narrative review discusses five cases of hypophosphataemia following intravenous iron infusion, a complication increasingly recognized in clinical practice.
Feasibility of Decentralised Response-Guided Albuminuria Monitoring to Optimise Empagliflozin and Finerenone Therapy in Type 2 Diabetes and Chronic Kidney Disease.
This Phase IV clinical trial evaluated the feasibility of a decentralised response-guided approach for monitoring urinary albumin-to-creatinine ratio (UACR) in adults with type 2 diabetes and chronic kidney disease…
Long-term remission of chronic-type adult T-cell leukemia/lymphoma associated with Graves' disease treated with methimazole.
A 58-year-old woman diagnosed with chronic-type adult T-cell leukemia/lymphoma (ATL) in 2022 experienced disease progression alongside the development of Sjögren's syndrome and Graves' disease in 2023.
Tofogliflozin alters amino acid metabolism in gut microbiota linked to hepatic transcriptomic signatures in MASLD.
This prespecified sub-analysis of a randomized controlled trial examined gut microbiota–liver associations in participants with MASLD and type 2 diabetes treated with tofogliflozin or glimepiride.
A narrative systematic review of definitions and diagnostic criteria for disordered eating and eating disorders in type 1 diabetes.
This systematic review examined definitions and diagnostic criteria for disordered eating in adults with type 1 diabetes (T1DE), analyzing 61 studies with 111,208 participants.
Role of bioprocessing in modifying cardiometabolic outcomes of an oat-based dairy alternative in a randomised controlled clinical intervention.
This randomized controlled trial investigated the effects of fermented and non-fermented oat-based products on cardiometabolic outcomes in 56 adults with mild metabolic deterioration over 12 weeks.
Clinical Trial: Phase 3 Trial of Resmetirom Versus Placebo in Metabolic Dysfunction-Associated Steatohepatitis-Reanalysis of Fibrosis Stage 2-3 Subset.
This phase 3 randomized controlled trial analyzed the efficacy of resmetirom in patients with metabolic dysfunction-associated steatohepatitis (MASH) and F2 or F3 fibrosis.
Prunella Oral Liquid in combination with Western medical treatment for Graves' disease: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed Prunella Oral Liquid added to Western medical treatment for Graves’ disease.
Seventeen-year follow-up of hypophosphatasia diagnosed in middle-aged siblings harboring a novel intronic and a rare missense ALPL gene mutation.
A 17-year follow-up of middle-aged siblings diagnosed with hypophosphatasia revealed painful proximal femoral stress fractures, generalized muscle and bone pain, and tooth loss.
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