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1022 articles
September 202624
Improving survival in Duchenne muscular dystrophy across eras: a systematic review and cumulative meta-analysis.
This systematic review and cumulative meta-analysis evaluated survival trends in Duchenne muscular dystrophy (DMD) across eras, analyzing over 13,000 patients.
Downbeat nystagmus without ataxia as an early manifestation of spinocerebellar ataxia, autosomal recessive type 10 (SCAR10): a case report.
A 23-year-old female with a history of migraine presented with a four-month history of progressive vestibular dizziness. Neurological examination revealed downbeat nystagmus without ataxia.
From target engagement to translational disconnect: A systematic review and narrative synthesis of direct tau-targeted clinical trials in Alzheimer's disease and primary tauopathies.
This systematic review examined 11 clinical trials of tau-targeted therapies in Alzheimer's disease and primary tauopathies.
Pathogenesis of the Holmes tremor due to cerebellar lesions: A case series with a narrative review.
This report discusses two patients with Holmes tremor associated with cerebellar lesions. MRI findings in both patients indicated Wallerian degeneration of the dentato-rubro-thalamic pathway (DRTP) and suggested…
Cognitive impairment as a manifestation of SPG7: case report.
A 42-year-old man with a 10-year history of dysarthria and 5 years of gait difficulties presented with cognitive symptoms over the last 3 years.
Neurologic complications of Evans syndrome.
A patient with severe Evans syndrome developed status epilepticus due to intracranial hemorrhage from profound treatment-refractory thrombocytopenia.
Acute-onset dysphagia: an uncommon presentation of myasthenia crisis.
A patient with undiagnosed myasthenia gravis presented with acute-onset dysphagia, indicative of a myasthenia crisis. The case highlights the potential triggers, including an acute exacerbation of chronic rhinosinusitis…
High-grade B-cell lymphoma presenting with bulbar palsy and Tapia syndrome: A case report.
A 46-year-old male presented with dysphagia, which led to the diagnosis of high-grade B-cell lymphoma. His symptoms included bulbar palsy and Tapia syndrome, which are uncommon initial manifestations of lymphoma.
Clinical challenges and individualized management of hypertensive emergency complicated by acute ischemic stroke: A case report and literature review.
Three patients with chronic hypertension presented with acute ischemic stroke during a hypertensive emergency. They were diagnosed based on clinical signs and imaging.
Progressive Axonal Neuropathy and Cerebellar Ataxia Associated with Homozygous Pathogenic POLG Mutation in a Patient of African Descent from Northern Minas Gerais/Jequitinhonha Valley, Brazil: A Case Report and Epidemiological Implications.
A 41-year-old man of African descent presented with progressive axonal sensorimotor neuropathy, cerebellar ataxia, dysarthria, and oculomotor abnormalities.
Non-convulsive status epilepticus revealing acute deterioration in AARS2 mutation-associated progressive leukoencephalopathy.
A 41-year-old woman with AARS2 mutation-associated leukoencephalopathy presented with rapid cognitive decline and altered mental status.
PHACE syndrome: a systematic literature review and illustrative case report of a patient with severe cerebrovascular and neurodevelopmental sequelae.
A 12-year-old girl with PHACE syndrome presented with a left V1-distribution facial hemangioma and significant cerebrovascular complications, including neonatal intraventricular hemorrhage, hydrocephalus, and a dural…
Glial fibrillary acidic protein in progressive supranuclear palsy: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated glial fibrillary acidic protein (GFAP) levels in progressive supranuclear palsy (PSP) compared to healthy controls and other parkinsonian disorders.
Epidemiology of multiple sclerosis in iran: an updated systematic review and meta-analysis.
This systematic review and random-effects meta-analysis updated estimates of multiple sclerosis (MS) prevalence and incidence in Iran. It included 56 articles comprising 142 individual studies.
Expanding the TBL1XR1 Disease Spectrum: Generalized Dystonia Associated with a New Genetic Variant.
A 61-year-old man with a long-standing misdiagnosis of cerebral palsy presented with neurodevelopmental disorder, mild ataxia, and generalized dystonia.
Fatal Myocarditis Relapse in a Patient with Myasthenia Gravis Treated with Efgartigimod Alfa: A Case Report.
A 39-year-old woman with AChR-positive generalized myasthenia gravis and a history of inflammatory myocarditis was treated with efgartigimod after inadequate response to intravenous immunoglobulin.
Ticagrelor-Aspirin With Thrombolysis by Infarct Patterns in Moderate Ischemic Stroke: TAPIS Subgroup Analysis.
This subgroup analysis of the TAPIS trial evaluated the impact of diffusion-weighted imaging infarction patterns on the efficacy and safety of ticagrelor-aspirin combined with thrombolysis in 1307 patients with moderate…
Investigating the influence of anti-seizure medications on aperiodic EEG activity.
This randomized controlled trial investigated the effects of lamotrigine and levetiracetam on aperiodic EEG activity in 13 healthy male volunteers.
Efficacy and safety of recombinant activated factor VII for spontaneous intracerebral Hemorrhage: a GRADE-assessed meta-analysis of randomized controlled trials using frequentist and Bayesian approaches.
This GRADE-assessed meta-analysis of seven randomized controlled trials compared recombinant activated factor VII (rFVIIa) with placebo in 2,022 patients with spontaneous intracerebral hemorrhage.
Exercise first: Acute aerobic exercise before practice selectively enhances spatial outcomes of motor learning - A systematic review and meta-analysis.
This pre-registered systematic review and random-effects meta-analysis examined whether acute aerobic exercise (AAE), performed before or after motor-task practice, differentially affects spatial and temporal…
The role of viral infections and other microbial factors in the pathogenesis of multiple sclerosis: a systematic review.
This systematic review assessed studies published from 2020 to 2025 on microbial factors and multiple sclerosis (MS) risk, activity, or progression.
Life-threatening multisystem sarcoidosis with neurological, renal, ocular and autoimmune haemolytic manifestations treated with intravenous immunoglobulin, plasma exchange, cyclophosphamide and infliximab.
A patient with multisystem sarcoidosis presented with encephalopathy, acute tubulointerstitial nephritis, optic neuritis, and autoimmune hemolytic anemia, resembling a stroke.
Potential contributors to variable penetrance of NOTCH3 p.Arg1231Cys Variant.
Two patients with the NOTCH3 p.Arg1231Cys variant presented with early-onset dementia, strokes, and extensive leukoencephalopathy.
Clinical characteristics of THAP1 related dystonia: a case report with phenotypic review.
A 58-year-old man presented with dysphagia and dysarthria at age 22, followed by progressive dystonic posturing affecting his upper limbs, face, neck, and lower limbs.
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