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1821 articles
September 202624
Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia.
This Phase III randomized controlled trial evaluated the efficacy of blinatumomab compared to traditional chemotherapy in children with newly diagnosed high-risk B-cell acute lymphoblastic leukemia (ALL).
Primary NTRK-rearranged spindle cell sarcoma of the colon with ETV6-NTRK3 fusion.
A man in his late 30s presented with abdominal pain, leading to a CT scan that revealed a large transmural tumor in the colon. The multidisciplinary team opted for immediate surgery without preoperative colonoscopy.
Orbital lymphoma presenting as preseptal cellulitis in a child with ataxia-telangiectasia.
A young child with ataxia-telangiectasia presented with left periorbital swelling, initially treated as a periorbital infection.
Evolving idiopathic multicentric Castleman disease with thrombocytopenia, anasarca, fever/hyperinflammation, renal dysfunction and organomegaly presenting with severe hypoalbuminaemia, serositis and bicytopenia before lymphadenopathy.
A man in his early 60s presented with abdominal symptoms, severe hypoalbuminaemia, thrombocytopenia, and marked inflammation, without evident lymphadenopathy.
Fine-Tuning, Retrieval-Augmented Generation, and Hybrid Adaptation of Language Models for Clinical Decision-Making in Health Care: Systematic Review.
This systematic review evaluated the effectiveness of fine-tuning, retrieval-augmented generation (RAG), and hybrid adaptation strategies for transformer-based language models in clinical decision-making.
Effects of self-acupressure on the fatigue-sleep disturbance-depression symptom cluster in breast cancer survivors: a phase III randomised controlled trial.
This phase III randomized controlled trial evaluated the effects of self-acupressure on the fatigue-sleep disturbance-depression symptom cluster (FSDSC) in breast cancer survivors.
First-line ibrutinib plus venetoclax for nonblastoid mantle cell lymphoma in patients ≥65 years old or with TP53 mutations.
The phase 3 SYMPATICO study evaluated the efficacy of first-line ibrutinib plus venetoclax in 78 patients with nonblastoid mantle cell lymphoma, specifically those aged ≥65 years or with TP53 mutations.
How I treat chemotherapy-induced thrombocytopenia with thrombopoietin receptor agonists.
The article discusses four cases of chemotherapy-induced thrombocytopenia (CIT), highlighting the complexities of managing this condition.
E7389-LF as a first-line chemotherapy for patients with metastatic/advanced HER2-negative breast cancer: results from the phase 1 dose-expansion part of study 114.
This phase 1 multicenter trial evaluated E7389-LF as a first-line chemotherapy in 26 Japanese patients with metastatic HER2-negative breast cancer.
Dynamic genetic and nongenetic RAS-pathway activation drives resistance to FLT3 and BCL2 inhibitor therapy.
This phase 1b clinical trial investigated the mechanisms of resistance to the BCL2 inhibitor venetoclax and the FLT3 inhibitor gilteritinib in patients with acute myeloid leukemia (AML).
Indocyanine green fluorescence imaging in minimally invasive liver resection for colorectal liver metastases: lesion detection and surgical outcomes-a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the use of indocyanine green (ICG) fluorescence imaging during minimally invasive liver resection for colorectal liver metastases (CRLM).
Cardiovascular risk-prediction models in cancer survivors: a meta-analysis.
This meta-analysis evaluated 34 studies involving 983,438 adult cancer survivors to assess cardiovascular risk-prediction models.
Approach to the patient with low-risk thyroid cancer.
Three patients diagnosed with low-risk differentiated thyroid cancer were presented to illustrate the management options available.
Hypothalamic-Pituitary Axis Involvement in Primary Central Nervous System Lymphoma.
This systematic review examined endocrine dysfunction related to the hypothalamic-pituitary axis in 99 adult patients with primary central nervous system lymphoma (PCNSL).
Congenital infantile fibrosarcoma of the foot.
A newborn boy presented with a smooth mass measuring approximately 4 cm on the sole of his right foot, initially suspected to be an atypical haemangioma.
Occult breast carcinoma presenting as paraneoplastic opsoclonus-myoclonus-ataxia syndrome.
A woman in her sixties presented with subacute opsoclonus and gait ataxia, leading to the diagnosis of opsoclonus-myoclonus-ataxia syndrome (OMAS).
Efficacy, safety and circulating tumor cell dynamics in patients treated with Eribulin for HER2-negative advanced breast cancer - results from the phase II DETECT IVb trial.
The phase II DETECT IVb trial evaluated the efficacy and safety of eribulin in patients with HER2-negative advanced breast cancer.
Postoperative ctDNA-Guided Adjuvant Therapy in Resected Colorectal Cancer: A Systematic Review and Meta-analysis of Prognostic Validity Versus Treatment-Decision Utility.
This systematic review and meta-analysis evaluated the prognostic validity and treatment-decision utility of postoperative circulating tumor DNA (ctDNA) in resected colorectal cancer.
Nutrition and physical activity interventions delivered to children and young people during cancer treatment: a systematic literature review.
This systematic review evaluated nutrition and physical activity interventions during cancer treatment in children and young people.
Analgesic Efficacy of Different Doses of Esketamine as an Adjuvant to Ropivacaine for Thoracoscopy-Guided Thoracic Paravertebral Block After Thoracoscopic Radical Resection for Lung Cancer: A Prospective Randomized Controlled Trial.
Thoracoscopy-guided thoracic paravertebral block (TG-TPVB) is a new analgesia technique; however, the duration of a single TG-TPVB is short.
A multidisciplinary intervention to support return to work of individuals with breast cancer: a prospective feasibility study.
This prospective feasibility study evaluated a multidisciplinary intervention aimed at supporting work reintegration for employed individuals with breast cancer facing work-related difficulties.
Topical ruxolitinib for chronic cutaneous graft-versus-host disease: a single-centre, randomised, double-blind, intra-patient-controlled phase 2 trial.
This single-centre, randomised, double-blind, intra-patient-controlled phase 2 trial evaluated the efficacy and safety of topical ruxolitinib 1.5% cream in patients with chronic cutaneous graft-versus-host disease…
Assessing the effect of chemotherapy dose reductions and time delay on event-free survival in Ewing Sarcoma: A retrospective analysis of the Euro Ewing 2012 trial.
This retrospective analysis of the Euro Ewing 2012 trial evaluated the impact of chemotherapy dose reductions and time delays on event-free survival (EFS) in Ewing Sarcoma patients.
Chemotherapy-free phase 1/2 trial of HRS-4642 plus adebrelimab in previously treated metastatic KRAS G12D-mutant pancreatic cancer.
This phase 1/2 clinical trial evaluated the chemotherapy-free combination of the KRAS G12D inhibitor HRS-4642 and PD-L1 blockade with adebrelimab in 48 previously treated patients with metastatic KRAS G12D-mutant…
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