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433 articles
February 20261
January 20269
Improvement in anemia and symptoms after switching from crovalimab to iptacopan in paroxysmal nocturnal hemoglobinuria.
A 72-year-old man with long-standing paroxysmal nocturnal hemoglobinuria developed breakthrough hemolysis and worsening anemia during crovalimab therapy after infectious enteritis.
GvHD and GRFS in patients with acute myeloid leukemia undergoing allogeneic HCT with treosulfan- versus reduced-intensity busulfan-based conditioning: a subgroup analysis of a randomized phase 3 trial.
This subgroup analysis of a randomized phase III trial compared treosulfan-fludarabine with reduced-intensity busulfan-fludarabine conditioning in 352 patients aged 31–70 years with acute myeloid leukemia undergoing…
Assessment of the safety and efficacy of micronized encapsulated ferric pyrophosphate in patients with iron deficiency anaemia: a phase-IV open-label clinical study.
This phase-IV, open-label, single-arm clinical study assessed micronized encapsulated ferric pyrophosphate (MEFP) in 60 adults aged 18–60 years with moderate iron deficiency anaemia.
Prolonged progression-free survival with zanubrutinib in relapsed/refractory CLL: an indirect treatment comparison versus other BTK inhibitors using multilevel network meta-regression.
This multilevel network meta-regression compared zanubrutinib with acalabrutinib and ibrutinib for relapsed/refractory chronic lymphocytic leukemia, estimating effects in general and high-risk populations.
Mucous Membrane Pemphigoid during CPX-351 Therapy Successfully Treated with Corticosteroids.
A 58-year-old man with acute myeloid leukemia with myelodysplasia-related changes achieved complete remission after CPX-351 induction and received a second consolidation course.
Risk factors of venous thromboembolism in ICU patients: a systematic review and meta-analysis.
This systematic review and meta-analysis examined factors associated with venous thromboembolism (VTE) among patients admitted to intensive care units. Of 2465 studies identified, 30 were included in pooled analyses.
Novel compound heterozygous ITGA2B mutations in Glanzmann thrombasthenia associated with adolescent osteoporosis.
A 14-year-old with Glanzmann thrombasthenia had asymptomatic radial osteoporosis without identified secondary causes. Platelet aggregation testing and flow cytometry supported type I disease, with CD41/CD61 expression…
The efficacy and safety of CAR-T therapy in relapsed or refractory multiple myeloma patients: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed the efficacy and safety of CAR-T therapy in patients with relapsed or refractory multiple myeloma.
Retroperitoneal Hematoma in Essential Thrombocythaemia: A Diagnostic Challenge.
An 85-year-old woman with essential thrombocythaemia, obesity, and hypertension developed pulmonary micro-embolism after elective right hip replacement and received high-dose enoxaparin.
December 20256
Immune thrombocytopenia triggered by dostarlimab in a patient with endometrial carcinoma: first reported case.
A 55-year-old woman receiving dostarlimab for relapsed endometrial carcinoma developed severe thrombocytopenia (3 × 10⁹/L) with rectal bleeding, creating a life-threatening presentation.
Pregnancy complicated by Factor XII deficiency: a case report and literature review.
A 27-year-old primigravida was found to have severe factor XII deficiency on routine prenatal screening. At 38 +5 weeks, she presented with vaginal spotting and spontaneous rupture of membranes.
Correlation between epigenetic modifier gene mutations and prognosis of patients with acute lymphoblastic leukemia: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed whether epigenetic modifier gene mutations are associated with survival in acute lymphoblastic leukemia (ALL).
Immunoglobulin M Multiple Myeloma: Case Report of a Rare Variant of Multiple Myeloma with Diagnostic and Treatment Challenges.
A 64-year-old woman presented with three weeks of persistent lower back pain. Testing showed anemia (hemoglobin 9.2 g/dL), an IgM level of 5,070 mg/dL, an M-spike of 3.09 g/dL, and monoclonal IgM lambda with an abnormal…
Central Venous Access Device Complications in Children With Leukemia: A Systematic Review and Meta-Analysis.
This systematic review and random-effects meta-analysis assessed central venous access device (CVAD) complications in children aged 18 years or younger receiving treatment for leukemia.
Prognosis of Immunocompromised Patients With Respiratory Failure Managed With Venovenous Extracorporeal Membrane Oxygenation.
This systematic review and meta-analysis examined mortality among immunocompromised adults with respiratory failure managed with venovenous extracorporeal membrane oxygenation (VV ECMO), compared with immunocompetent…
November 20252
Unlocking Rare Diagnoses: The Essential Role of Molecular Techniques in Hemoglobin Agrinio. A Case Report.
A girl had anemia from birth and high transfusion needs. Evaluation led to a recent diagnosis of homozygous Hb Agrinio, a nondeletional alpha-thalassemia variant caused by an α2-globin substitution (α29(B10) Leu→Pro…
Heavy Menstrual Bleeding in Women Treated with Direct Oral Anticoagulants: Results of the Prospective HEMBLED Registry.
The prospective, multicentre, noninterventional HEMBLED registry compared spontaneous menstrual bleeding among women with venous thromboembolism receiving therapeutic doses of direct oral anticoagulants, without…
October 20253
Spontaneous Remission and Subsequent Relapse in Pediatric Acute Myeloid Leukemia (AML-M5): A Case Report and Literature Review.
A child with acute myeloid leukemia, French-American-British subtype M5 (AML-M5), experienced spontaneous remission after receiving blood transfusions and anti-infective therapy, without leukemia-specific treatment.
Pharmacokinetics, Hemostatic Efficacy, and Safety of a New Human Fibrinogen Concentrate in Adult and Pediatric Patients with Congenital Fibrinogen Deficiency.
This prospective, multinational, open-label, single-arm trial assessed pharmacokinetics, pharmacodynamics, surrogate efficacy, and safety of BT524 human fibrinogen concentrate in adults and children with congenital…
Innovative sequential therapy in a rare case of refractory Erdheim-Chester disease with bilateral pulmonary involvement.
A 44-year-old man with Erdheim-Chester disease confirmed by lung biopsy presented with persistent fatigue, intermittent low-grade fever, and bilateral interstitial lung disease.
August 20252
Genetic background of Richter transformation of atypical chronic lymphocytic leukemia to diffuse large B-cell lymphoma - a case study.
A 29-year-old woman with atypical chronic lymphocytic leukemia (aCLL) was initially treated with fludarabine, cyclophosphamide, and rituximab.
Striking effectiveness of siltuximab-based treatment in refractory idiopathic multicentric Castleman disease resembling IgG4-related disease.
A 38-year-old man presented with persistent dry cough, generalized lymphadenopathy, and fatigue, with elevated serum IgG4. Inguinal lymph node biopsy showed plasma cell-type multicentric Castleman disease, including…
June 20251
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