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1022 articles
September 202624
Increased Libido Following Brivaracetam Initiation: A Case Report of Temporal Lobe Epilepsy.
A woman in her 70s with drug-resistant temporal lobe epilepsy and mild cognitive impairment experienced increased libido and self-stimulatory behavior after starting brivaracetam for her seizures.
Could Subjective Cognitive Complaints Give the Facts of Objective Cognitive Impairments in Non-Central Nervous System Cancer? A Systematic Review.
This systematic review examined the relationship between subjective cognitive complaints (SCCs) and objective neuropsychological assessments in non-central nervous system cancer patients.
The Neuroscience of Religious and Spiritual Practices: A Systematic Review of Neurotheological Evidence.
This systematic review examined the neurobiological effects of religious and spiritual practices across various traditions, synthesizing findings from 105 studies using neuroimaging techniques.
Biallelic VPS41 Variants in Autosomal Recessive Spinocerebellar Ataxia 29 Resolved by Long-Read Sequencing and RNA Analysis.
Biallelic variants in VPS41, encoding a subunit of the HOPS complex, cause autosomal recessive spinocerebellar ataxia 29 (SCAR29), a rare neurodevelopmental disorder with an incompletely defined phenotypic and molecular…
The Role of Hippocampal Interneuron Migration in Neurodevelopmental Disorders: A Systematic Review.
This systematic review examined the role of aberrant hippocampal interneuron migration in neurodevelopmental disorders, analyzing 29 studies.
Neuropathy With Demyelinating Features in a Patient With Biallelic HARS1 Variants.
A 25-year-old male presented with Charcot-Marie-Tooth disease type 1 and mild intellectual disability. Genetic analysis revealed he was compound heterozygous for two pathogenic HARS1 variants: a maternally inherited…
Intensive blood pressure lowering after spontaneous intracerebral haemorrhage for secondary stroke prevention (RECAP-ICH): a systematic review and individual participant data meta-analysis.
This systematic review and individual participant data meta-analysis evaluated the effects of intensive blood pressure-lowering treatment on recurrent stroke in 2944 adults with a history of spontaneous intracerebral…
Nonsystemic Vasculitic Neuropathy Presenting as Inflammatory Demyelinating Polyradiculoneuropathy.
A 57-year-old man presented with acute ascending weakness, sensory loss, and facial weakness following a febrile illness. Initial improvement was followed by neurological decline despite treatment.
Possible Contribution of Multiple Sclerosis Pathology to Treatment-Resistant Schizophrenia: A Case Study.
A woman in her 50s presented with persecutory delusions and a sense of being surveilled, initially diagnosed with schizophrenia. Despite long-term antipsychotic treatment, her symptoms worsened.
Anakinra in Severe RSV-Associated Autoinflammatory Encephalopathy With Delayed ADEM-Like Changes.
Two previously healthy children developed rapidly progressive encephalopathy following RSV infection. Initial brain MRI scans were normal, but subsequent imaging revealed multifocal white matter lesions resembling acute…
Biallelic SCO2 Variants Presenting as Motor-Predominant Axonal Neuropathy With Complex IV Deficiency.
SCO2 encodes a mitochondrial copper chaperone required for cytochrome c oxidase (COX) assembly and is classically associated with severe multisystem mitochondrial disease.
Mechanical Thrombectomy in Ischemic Stroke With a Medium or Distal Arterial Occlusion: The DISCOUNT Randomized Clinical Trial.
The DISCOUNT randomized clinical trial evaluated the efficacy of thrombectomy plus medical treatment versus medical treatment alone in patients with acute ischemic stroke due to medium or distal vessel occlusions.
Late-Onset Tay-Sachs Disease With SMALED-Like Muscle MRI Pattern Despite a Distinct Clinical Phenotype.
Two female patients in their second decade presented with slowly progressive, lower limb-predominant flaccid weakness and tremor.
Long-Term Safety and Efficacy of Efgartigimod PH20 in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: ADHERE/ADHERE+ Trial Interim Analysis.
The ADHERE/ADHERE+ trial evaluated the long-term safety and efficacy of efgartigimod PH20 in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
Amyloid-Like Immunoglobulin Deposition Neuropathy.
A case of amyloid-like immunoglobulin deposition neuropathy was presented, characterized by predominant neuropathic pain, skin changes, and progressive distal sensory neuropathy.
Boy in the Barrel: Excruciating Paroxysmal Pain Disorder Associated With an SCN9A Gain-of-Function Variant.
A young man presented with severe childhood-onset paroxysmal pain triggered by heat, alongside autonomic dysfunction and skeletal abnormalities.
Epilepsy-Related Psychosis in Drug-Resistant Epilepsy With Nonconvulsive Status Epilepticus and Difficult Antipsychotic Titration: A Case Report.
A man in his late 50s with drug-resistant epilepsy and recurrent psychosis presented with reduced responsiveness and fluctuating alertness during medication adjustment.
Ketone Bodies Derived From Medium-Chain Triglycerides Support Brain Metabolism and Function Under Hypoglycemia in Type 1 Diabetes Mellitus.
This randomized controlled trial investigated the effects of medium-chain triglycerides (MCTs) on brain metabolism during hypoglycemia in individuals with type 1 diabetes mellitus (T1DM).
Looking Beyond the Midline: An Uncommon Etiology of Internuclear Ophthalmoplegia of Abduction Due to Cerebral Venous Thrombosis.
A 27-year-old man presented with headache, vomiting, seizures, and altered sensorium. Examination revealed bilateral disc edema and abduction restriction of the right eye, consistent with internuclear ophthalmoplegia…
Acute Spinal Cord Infarct Secondary to Fibrocartilaginous Embolism Treated With Tenecteplase.
A 56-year-old male with hypertension experienced sudden left arm and leg weakness following a Valsalva maneuver. Examination revealed dense flaccid paralysis.
De Novo MFN2 p.Arg95Met in Severe Charcot-Marie-Tooth Disease Type 2A.
A 30-year-old Taiwanese woman presented with severe axonal sensorimotor neuropathy, characterized by early-onset weakness, distal wasting, optic atrophy, and bilateral sensorineural hearing loss.
Blood pressure parameters and cognitive decline and dementia after stroke or transient ischemic attack: results from the PROGRESS trial.
This randomized controlled trial analyzed blood pressure parameters in 5128 participants with stroke or transient ischemic attack from the PROGRESS trial.
A Phase I and Biodistribution Study of Ifabotuzumab, a Humanized Agonistic EphA3-Targeted Antibody, in Patients with Recurrent Glioblastoma.
This Phase I multicenter study evaluated the safety and biodistribution of ifabotuzumab, an EphA3-targeted antibody, in 12 adults with recurrent glioblastoma.
The effects of neuromodulation through brainwave entrainment on pain in women with fibromyalgia: a randomized controlled clinical trial with follow-up.
This randomized controlled trial examined the effects of brainwave entrainment (BWE) versus music therapy on pain management in 84 women with fibromyalgia.
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