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484 articles
October 202624
Crystalline κ light-chain proximal tubulopathy and Auer rod-like inclusions presenting as Fanconi syndrome: A case report.
A 53-year-old man presented with Fanconi syndrome, with hypokalemia, hypophosphatemia, mild metabolic acidosis, and renal glucosuria.
Large Carinal Chondrosarcoma: Resection of the Main Carina, Distal Trachea, and Orifices of the Mainstem Bronchi and Construction of a New Carina.
A 23-year-old man presented with dyspnea, fatigue, and cough. CT showed a lobulated mass anterior to the distal trachea and main carina; bronchoscopy demonstrated carinal widening, significant stenosis of both mainstem…
SOX10 Expression in Primary Salivary Gland Tumors: A Meta-Analysis.
This PRISMA-guided systematic review and meta-analysis assessed SOX10 immunohistochemical expression across primary salivary gland tumors. It included 35 studies comprising 1146 histological and 35 cytological samples.
Lymphoplasmacytic Lymphoma Involving Marrow-Containing Submandibular Heterotopic Ossification: A Case Report and Literature Review.
A 77-year-old man presented with a gradually enlarging, increasingly uncomfortable calcified nodule in the left submandibular region.
Case Report WIN-MTB-2024001 - WIN International Molecular Tumor Board: A 55-year-old male with glioblastoma exhibiting amplifications in MDM2 and EGFR.
A 55-year-old man with high-grade glioblastoma had next-generation sequencing findings that included MDM2 and EGFR amplifications and a CDKN2A frameshift mutation.
WIN-MTB-2024002 - WIN International Molecular Tumor Board: A 52-year-old female with unmeasurable Stage IIIc colon cancer.
A 52-year-old woman with stage IIIc colon cancer had KRAS, TP53, IDH1, and APC mutations, high tumor PD-L1 expression, and elevated VEGFR1 and VEGFR3.
Impact of Phosphatidylinositol 3-Kinase and B-Raf Mutations in Rat Sarcoma Wild-Type Metastatic Colorectal Cancer.
This systematic review and meta-analysis assessed whether PIK3CA and BRAF mutations were associated with outcomes among patients with RAS wild-type metastatic colorectal cancer receiving first-line EGFR inhibitor…
Ectopic thyroid tissue accompanied by distinct blood supply and lymphoid tissue within the carotid sheath - a case report.
A 42-year-old man had an asymptomatic right-sided neck mass detected during a routine examination. Ultrasound showed a normally located thyroid and a well-defined 1.3 cm × 0.9 cm × 0.5 cm mass with echotexture similar…
Complete remission of minimal change disease after antiviral monotherapy in a patient with immune-active chronic hepatitis B: A case report.
A 42-year-old woman presented with generalized edema, weight gain, hypoalbuminemia, and nephrotic-range proteinuria, with a urine protein-to-creatinine ratio of 4.3 and preserved renal function.
Bilateral lower limb dysfunction due to acute hematoma in the lumbar ligamentum flavum: A case report and literature review.
A 71-year-old man developed sudden lower back pain without an identifiable trigger, followed by worsening pain, numbness, and weakness in both legs.
Spontaneous gene mutation encounters a paternal genetic variant: Nemaline myopathy: a case report and literature review.
A 21-year-old man had progressive weakness beginning in the distal lower limbs at age 3, later affecting proximal and masticatory muscles.
Multimodal imaging features of nuclear protein in testis carcinoma of the submandibular gland: a case report.
A 32-year-old man presented with a painless left submandibular mass that enlarged from 2 cm to approximately 4 cm within 1 month, with new ipsilateral pharyngeal and periauricular pain.
Primary Hepatic Neuroendocrine Neoplasms: Systematic Review and Expert Pathologist Reappraisal Using the WHO 6th Edition Framework.
Primary hepatic neuroendocrine neoplasms (PHNENs) are exceedingly rare. Published evidence often lacks adequate clinicopathological support for a primary hepatic origin and uses inconsistent historical terminology.
Prognostic value of measuring LSC frequency in AML: a systematic review and meta-analysis.
This systematic review and reconstructed individual patient data meta-analysis assessed whether leukemia stem cell (LSC) measurements predict outcomes in patients with acute myeloid leukemia at diagnosis or in…
Dynamics of QuantiFERON-TB Gold Plus Results in a Large TB Preventive Treatment Trial Across 3 High-Burden HIV/TB Countries.
This longitudinal analysis of a randomized trial assessed serial QuantiFERON-TB Gold Plus (QFT-Plus) results in people with HIV enrolled in Ethiopia, Mozambique, and South Africa and assigned to three TB preventive…
Phase I Trial of IL13Rα2-Targeted CAR T-cell Therapy for Recurrent Malignant Glioma: Clinical Results and Pharmacokinetics.
This single-centre, open-label phase I trial assessed intravenous autologous IL13Rα2-targeted CAR T cells in adults with recurrent, IL13Rα2-expressing grade 3–4 gliomas after standard treatment.
AI-Based Pathology Classifier Predicts Sensitivity to Enzalutamide in Metastatic Hormone-Sensitive Prostate Cancer: A Biomarker Analysis of the ENZAMET Trial.
This prespecified biomarker analysis of the randomised ENZAMET trial assessed whether a locked artificial intelligence pathology image classifier (APIC) identified differential overall-survival benefit from enzalutamide…
Multimodal assessment of exceptional responders refines subtyping-directed precision treatment in HR+/HER2- breast cancer.
This clinical-trial analysis examined whether multimodal tumour and clinical features could clarify exceptional responses to subtype-directed treatment in locally advanced HR+/HER2− breast cancer.
Behind the Sella: A Rare Case of Pituicytoma Mimicking a Pituitary Adenoma.
A 48-year-old man presented with symptoms of hypogonadism, headaches, and visual field defects. Testing showed hypogonadotropic hypogonadism and hyperprolactinemia, while MRI revealed a sellar-suprasellar mass initially…
Giant Cystic Lymphangioma of the Transverse Mesocolon in a 7-Year-Old Child: A Case Report.
A 7-year-old girl presented with several weeks of vomiting, abdominal pain and progressive distension. Examination found a large abdominal mass; laboratory results were unremarkable.
Early extracranial dissemination with prolonged survival in IDH-wildtype glioblastoma: case study and comprehensive literature review.
A 65-year-old woman with IDH-wildtype, MGMT-methylated glioblastoma presented with seizures, right hemiplegia, and expressive aphasia.
Recurrent Primary Angiosarcoma of the Breast: Challenges and Pitfalls in a Case Report.
A patient presented with a breast lesion and skin involvement; histopathology and immunohistochemistry confirmed low- to intermediate-grade primary breast angiosarcoma.
Fibro-Inflammatory Signaling, Fibrosis, and Microvascular Ischemia as Convergent Translational Substrates of Sudden Cardiac Death in Hypertrophic Cardiomyopathy: A Systematic Review.
This systematic translational review examined whether fibro-inflammatory signaling, fibrosis, and microvascular ischemia converge as substrates for ventricular arrhythmia and sudden cardiac death in hypertrophic…
Atypical presacral masses in Currarino syndrome: a case series.
The report describes three patients with Currarino syndrome, a congenital condition involving a sacral anomaly, anorectal malformation, and presacral mass.
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