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1316 articles

October 202624

Clinical ResearchOncology (Medical)

Chemotherapy backbone and outcomes of immune checkpoint inhibitor combinations across solid tumors: a pan-tumor network meta-analysis.

This systematic review and network meta-analysis examined phase II–III randomised trials comparing first-line immune checkpoint inhibitor (ICI) plus chemotherapy with chemotherapy alone across solid tumours, assessing…

OncologistOct 7, 2026Read summary
Clinical ResearchOncology (Medical)

Dose response relationship of medical cannabis and symptom control in patients with pancreatic cancer: an analysis of the CANPAN trial.

This analysis of the CANPAN pilot waitlist-control randomized trial examined cannabis use, patient-reported outcome completion, and THC dose-response among 32 cannabis-naïve patients with newly diagnosed locally…

OncologistOct 7, 2026Read summary
Clinical ResearchInfectious Diseases

A Phase 1/2 Dose-Ranging Safety and Immunogenicity Study of mRNA-Based Candidate Pandemic Influenza Vaccines in Healthy Adults.

This randomised phase 1/2 dose-ranging study evaluated the safety, reactogenicity, and immunogenicity of mRNA-1018 pandemic influenza vaccine candidates in healthy adults.

Clin Infect DisOct 7, 2026Read summary
Clinical ResearchDermatology

Acrokeratosis paraneoplastica (Bazex syndrome): a systematic review and quantitative analysis of 106 cases.

Acrokeratosis paraneoplastica (Bazex syndrome) is an obligate paraneoplastic dermatosis characterized by symmetrical acral psoriasiform lesions and nail dystrophy.

OncologistOct 7, 2026Read summary
Clinical ResearchPsychiatryOpen access

Anxiety and Depression in Athletes of Different Levels Without Current Injury: A Systematic Review With Meta-Analyses.

This systematic review and random-effects meta-analysis examined anxiety and depression in athletes across competitive levels, including those without current injury.

J Athl TrainOct 7, 2026Read summary
Clinical ResearchCardiology

EACTS Expert Consensus Document on aortic valve repair and valve-sparing aortic root replacement procedures.

This EACTS Expert Consensus Document critically reviews evidence on aortic valve repair and valve-sparing aortic root replacement for aortic regurgitation and proximal thoracic aortic aneurysms across age groups.

Eur J Cardiothorac SurgOct 7, 2026Read summary
Clinical ResearchInfectious Diseases

Safety and Immunogenicity of the Live-Attenuated Quadrivalent Dengue Vaccine V181 Compared With Butantan-DV Among Healthy Adults in Brazil: A Randomized, Double-Blind, Phase 2 Trial.

This randomized, double-blind, active-comparator phase 2 trial compared the safety and immunogenicity of single-dose quadrivalent dengue vaccines V181 and Butantan-DV in healthy adults in Brazil.

Clin Infect DisOct 7, 2026Read summary
Clinical ResearchInfectious DiseasesOpen access

Efficacy of direct-acting antiviral regimens for acute HCV infection: a systematic review and meta-analysis.

This systematic review and meta-analysis assessed interferon-free dual direct-acting antiviral regimens for acute or recently acquired HCV infection.

Virol JOct 7, 2026Read summary
Clinical ResearchInfectious Diseases

Multidimensional Poverty and Implementation Reach of Household Contact Tracing for Tuberculosis in South Africa: Analysis of a Randomized Trial.

This analysis of a cluster-randomized trial in South Africa examined whether household multidimensional poverty was associated with the reach of household contact tracing (HHCT) for tuberculosis.

Clin Infect DisOct 7, 2026Read summary
Clinical ResearchInfectious Diseases

Immunogenicity and Safety of the Adjuvanted Respiratory Syncytial Virus Prefusion F Protein-Based Vaccine When Co-administered With the Adjuvanted Recombinant Herpes Zoster Subunit Vaccine in Adults ≥ 50 Years of Age.

This phase III, open-label, randomised trial compared co-administration of adjuvanted RSVPreF3 and recombinant zoster vaccine (RZV) with administration one month apart in adults aged ≥50 years.

Clin Infect DisOct 7, 2026Read summary
Clinical ResearchGeneral Surgery

Preoperative pathways in adults with multiple long-term conditions undergoing major surgery: a systematic review.

This systematic review examined preoperative interventions, pathways and protocols for adults with multiple long-term conditions (MLTCs) undergoing major surgery.

BMJ OpenOct 7, 2026Read summary
Clinical ResearchHematologyOpen access

T-cell-redirecting therapies in early relapsed multiple myeloma: a systematic review and network meta-analysis.

This systematic review and network meta-analysis compared T-cell-redirecting regimens in randomized phase 3 trials involving patients with multiple myeloma after at least one prior line.

J Hematol OncolOct 7, 2026Read summary
Clinical ResearchNeurologyOpen access

Healthcare costs and burden of myasthenia gravis for patients and society: a systematic review.

This systematic review examined healthcare and societal costs associated with myasthenia gravis (MG), including 44 studies selected from 1,374 records.

J NeurolOct 7, 2026Read summary
Clinical ResearchPulmonology

Manual compared to automated closed-loop oxygen control strategies in hospitalised adults: a systematic review and meta-analysis.

This systematic review and meta-analysis assessed randomised controlled trials comparing closed-loop oxygen control (CLOC) with manual adjustment in hospitalised adults receiving noninvasive oxygen.

Eur Respir RevOct 7, 2026Read summary
Clinical ResearchAnesthesiology

Effects of remimazolam versus propofol on cerebral oxygenation in elderly patients undergoing prone spine surgery: study protocol for a randomised controlled trial.

This article describes the protocol for a prospective, single-centre randomised controlled trial comparing remimazolam with propofol-based total intravenous anaesthesia in elderly patients undergoing elective thoracic…

BMJ OpenOct 7, 2026Read summary
Clinical ResearchGeriatrics

Dose- and modality-specific effects of exercise on BDNF and depression in middle-aged and older adults with mild cognitive impairment: A Bayesian network meta-analysis.

This Bayesian network dose-response meta-analysis examined randomized controlled trials of exercise in adults aged 50 years or older with mild cognitive impairment (MCI), assessing peripheral brain-derived neurotrophic…

PLoS OneOct 7, 2026Read summary
Clinical ResearchOncology (Medical)

Systematic Review and Meta-Analyses of Time-Use, Productivity, and Labor Outcomes Among Unpaid Cancer Caregivers.

This systematic review and meta-analysis pooled evidence on time use and labor outcomes among unpaid caregivers of adults with cancer.

JCO Glob OncolOct 7, 2026Read summary
Clinical ResearchNeurosurgeryOpen access

The efficacy of surgical interventions for trigeminal neuralgia in multiple sclerosis: A systematic review.

This systematic review with narrative synthesis assessed surgical treatments for trigeminal neuralgia in people with multiple sclerosis, using studies reporting Barrow Neurological Institute Pain Scale outcomes.

Neurosurg RevOct 7, 2026Read summary
Clinical ResearchPsychiatry

Early interventions for primary care patients with stress-related mental ill health: a randomised controlled non-inferiority trial of a nurse-led collaborative care intervention versus cognitive behavioural therapy.

This randomised controlled non-inferiority trial compared nurse-led collaborative care (CC) with psychologist-guided self-help cognitive behavioural therapy (GSH-CBT) in 172 adults with mild to moderate stress-related…

BMJ Ment HealthOct 7, 2026Read summary
Clinical ResearchOrthopedic Surgery

Costs and health-related quality of life of non-operative and surgical treatment modalities for displaced distal radius fractures: a comprehensive overview based on the CAST study.

This cost and health-related quality-of-life analysis used data from the multicenter cluster-randomized CAST trial of adults with displaced distal radius fractures.

Eur J Trauma Emerg SurgOct 7, 2026Read summary
Clinical ResearchEndocrinologyOpen access

Betaine supplementation modulates mitochondrial and redox-related adaptations in premenopausal women with overweight: a randomized controlled trial.

This randomized controlled trial examined whether eight weeks of betaine supplementation (3 g/d) affected mitochondrial-associated and redox measures in premenopausal women with overweight or obesity.

Eur J NutrOct 7, 2026Read summary
Clinical ResearchOncology (Medical)Open access

A comparison of perioperative outcomes for da Vinci robotic-assisted, laparoscopic and open surgery in oncologic procedures: a systematic literature review and meta-analysis of evidence from China.

This systematic review and meta-analysis pooled 116 comparative studies published from 2010 to 2024 on da Vinci robot-assisted surgery (dV-RAS) versus laparoscopic/video-assisted thoracoscopic surgery (LAP/VATS) or open…

J Robot SurgOct 7, 2026Read summary
Clinical ResearchGeneral SurgeryOpen access

Surgeon task load, ergonomics, and clinical outcomes in laparoscopic versus robotic-assisted inguinal hernia repair: a systematic review and meta-analysis of randomized controlled trials.

This systematic review and meta-analysis examined randomized controlled trials comparing robotic-assisted (RIHR) with conventional laparoscopic inguinal hernia repair (LIHR), focusing on surgeon workload, ergonomics…

J Robot SurgOct 7, 2026Read summary
Clinical ResearchEndocrinologyOpen access

Disparities in GLP-1RA and SGLT2i Uptake: a Systematic Review and an Equity-First Framework for Cardiovascular-Kidney-Metabolic Care.

This systematic review synthesised U.S. evidence on disparities in prescribing and initiation of GLP-1 receptor agonists and SGLT2 inhibitors, and proposed an equity-first framework for cardiovascular-kidney-metabolic…

Curr Cardiol RepOct 7, 2026Read summary

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