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1821 articles
August 202624
Efficacy, safety, and biomarker analysis of neoadjuvant camrelizumab plus apatinib as a chemotherapy-free strategy for early-stage triple-negative breast cancer: a phase II study.
This phase II clinical trial evaluated the efficacy and safety of neoadjuvant camrelizumab plus apatinib in patients with early-stage triple-negative breast cancer (TNBC) and high tumor-infiltrating lymphocytes (TILs).
Pelvic floor muscle training for erectile function in men undergoing radical prostatectomy: a systematic review of randomized controlled trials.
This systematic review evaluated the effectiveness of pelvic floor muscle training (PFMT) on erectile function (EF) in men post-radical prostatectomy, analyzing twelve randomized controlled trials.
Radiation Associated Undifferentiated Pleomorphic Sarcoma of the Neck 2 Decades After External Beam Radiation for Medullary Thyroid Carcinoma: A Case Report and Literature Review.
A 54-year-old man developed a painless neck mass 22 years after receiving 59.4 Gy radiation for medullary thyroid carcinoma.
Impact of patient positioning on the efficacy and safety of doxycycline pleurodesis in malignant pleural effusion: a pilot randomized trial.
This pilot randomized trial evaluated the efficacy and safety of doxycycline pleurodesis in 40 patients with malignant pleural effusion, comparing a standard rotation protocol to a non-rotation approach.
Exercise prehabilitation in head and neck cancer patients proposed for definitive chemoradiotherapy: The FIT4TREAT randomized controlled trial.
The FIT4TREAT randomized controlled trial evaluated the impact of exercise prehabilitation (EP) on functional capacity in patients with head and neck cancer scheduled for definitive chemoradiotherapy.
18 F-fluciclovine PET Imaging of Non-PSMA Expressing High-risk Primary Prostate Cancer.
A 67-year-old man with rising PSA and a palpable prostate lesion had a large PI-RADS 5 lesion on MRI. Biopsy showed high-grade prostate cancer (Gleason score 9 [4+5], grade group 5).
Phase II Study of Posttransplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis After HLA-Mismatched Unrelated Donor Reduced Intensity Transplantation: Results From the ACCESS Trial Expansion Cohort.
This prospective, multicenter phase II study evaluated posttransplant cyclophosphamide (PTCy)-based graft-versus-host disease prophylaxis in adults receiving peripheral blood stem cell transplantation from…
Long-Term Oncologic Outcomes of Neoadjuvant Tumor-Directed Immunotherapy (PROSTVAC) Before Radical Prostatectomy for Localized Prostate Cancer: A Secondary Analysis of a Neoadjuvant Trial.
This secondary analysis of a phase II neoadjuvant trial assessed long-term oncologic outcomes in 26 patients with localized prostate cancer who received PROSTVAC before radical prostatectomy.
The management of complex patients with inoperable stage III NSCLC: practical lessons from case-based discussion.
This article presents four case studies of patients with inoperable stage III non-small cell lung cancer discussed at a UK academic webinar.
Subcentimeter Ileal Neuroendocrine Tumor Resection for Obscure Gastrointestinal Bleeding Followed by Pacemaker-Treated Sick Sinus Syndrome: A Case Report.
A 72-year-old man presented with melena and abdominal discomfort, with prior endoscopies yielding no diagnosis. Multiphase computed tomographic enterography identified an 11×8 mm enhancing nodule in the distal small…
Prognostic significance of systemic immunoinflammatory biomarkers and pathological features in clear cell renal cell carcinoma: a multicenter study.
This multicenter retrospective study evaluated systemic immunoinflammatory biomarkers and pathological features to develop a prognostic model for overall survival (OS) in clear cell renal cell carcinoma (ccRCC).
Liver transplant allocation by milan criteria may exclude eligible HCC patients without survival benefit - a post-hoc analysis of the SiLVER study.
This post-hoc analysis of the SiLVER Study evaluated the Milan criteria for liver transplant eligibility in 485 patients with hepatocellular carcinoma (HCC).
Ivonescimab in combination with chemotherapy in advanced or metastatic gastric cancer (GC) or esophagogastric junction cancer (EGJC): The UCGI 52 - GRACIE trial.
The GRACIE trial is a multicenter, open-label phase II study evaluating the efficacy and safety of Ivonescimab combined with FOLFOX chemotherapy in 88 patients with advanced or metastatic gastric cancer or…
Effect of Vutrisiran According to Baseline Tafamidis Use in Transthyretin Amyloidosis With Cardiomyopathy: Insights From HELIOS-B.
This randomized controlled trial evaluated the effects of vutrisiran in patients with transthyretin amyloidosis with cardiomyopathy (ATTR-CM), stratified by baseline tafamidis use.
Heterogeneous associations of antidiabetic medications with cancer prognosis: Evidence from 61 studies with over 1.1 million patients.
This meta-analysis evaluated the prognostic effects of seven antidiabetic medication classes in over 1.1 million cancer patients, primarily with type 2 diabetes.
Effect of Rivoceranib 200 mg Once Daily on the Pharmacokinetics of a Cocktail Probe Substrate of Cytochrome P450 Enzymes: A Phase I Trial in Healthy Volunteers.
This Phase I trial assessed the impact of rivoceranib 200 mg once daily on the pharmacokinetics of various cytochrome P450 substrates in 18 healthy volunteers.
Successful treatment of refractory hemophagocytic lymphohistiocytosis complicating Epstein-Barr virus-positive classic Hodgkin lymphoma with rituximab.
A male in his early 70s with advanced EBV-positive mixed-cellularity classic Hodgkin lymphoma presented with cervical lymphadenopathy, fever, and hepatosplenomegaly.
A case of diffuse large B-cell lymphoma achieving complete remission with epcoritamab after pseudoprogression.
A 58-year-old male with diffuse large B-cell lymphoma (DLBCL) achieved complete remission after fourth-line therapy but experienced pelvic lymphadenopathy 26 months later, indicating relapse.
Post-pancreatectomy Liver Injury After Mayo Clinic Class Ia Celiac Axis Resection: Illustration of This Newly Described Entity with Delayed Hepatic Artery Revascularization.
A 59-year-old patient with locally advanced pancreatic body cancer received extended neoadjuvant FOLFIRINOX and underwent pancreatosplenectomy with Mayo Clinic class Ia celiac artery resection.
Implications of Mobile Applications for Breast Surgery: A Systematic Review.
This systematic review evaluated mobile applications designed to assist patients undergoing breast surgery across various stages of care.
Prospective Clinical Trial on Expanding the Eligibility Criteria for Targeted Axillary Dissection after Neoadjuvant Systemic Therapy in Breast Cancers with Advanced Nodal Disease.
This prospective clinical trial evaluated the effectiveness of targeted axillary dissection (TAD) in patients with advanced nodal disease (clinical N1 to N3) undergoing neoadjuvant chemotherapy.
Epithelioid renal angiomyolipoma: Clinical characteristics, treatment strategies, and oncological outcomes-An individual patient data meta-analysis of 259 cases.
This meta-analysis examined 259 cases of epithelioid angiomyolipoma (eAML), a rare malignant renal tumor. The study found a 39% recurrence rate at a median follow-up of 21 months, with significant risk factors including…
Catatonia in a 13-Year-Old With T-Cell Lymphoblastic Lymphoma Following Intrathecal Methotrexate.
A 13-year-old girl with T-cell lymphoblastic lymphoma exhibited agitation, confusion, and catatonia five days after receiving intrathecal methotrexate.
Cytological Identification of a Rhabdoid Variant of Pancreatic Neuroendocrine Neoplasm.
A 48-year-old woman presented with an incidental pancreatic head mass. Cytological analysis from endoscopic ultrasound-guided fine-needle aspiration revealed tumor cells with eccentric nuclei and prominent eosinophilic…
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