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1845 articles
July 202624
Identification and validation of TP53/p53 status as a prognostic marker in penile squamous cell carcinoma: Evidence from a cohort study and meta-analysis.
This study investigated the prognostic value of TP53/p53 status in penile squamous cell carcinoma (pSCC) using a single-center cohort and a meta-analysis.
Ex Situ Hepatectomy and Autologous Liver Transplantation for Recurrent Pheochromocytoma invading the Retrohepatic Vena Cava: Case report.
A 64-year-old woman with recurrent pheochromocytoma invading the retrohepatic inferior vena cava underwent liver autotransplantation after conventional resection methods were deemed inadequate.
Tuberculosis Mimicking Tumor Progression on Dual-tracer 68Ga-DOTATATE and 18F-FDG PET/CT in Metastatic Neuroendocrine Tumor of Unknown Primary: A Potential Imaging Pitfall in Neuroendocrine Tumor Surveillance.
An elderly woman with a metastatic neuroendocrine tumor of unknown primary, who had a partial response to [177Lu]Lu-DOTATATE PRRT, presented with new hypermetabolic cervical lymph nodes on follow-up PET/CT scans.
Partial Remission in Pediatric Relapsed Neuroblastoma After Multiple Cycle Low-Dose 211 At-MABG Therapy.
An 11-year-old boy with relapsed, poorly differentiated left adrenal neuroblastoma and multiple bone metastases was treated with low-dose 211 At-MABG-targeted alpha therapy after failing prior multimodal therapy.
Incidental Detection of Remote Ictal Hypermetabolism on FDG PET/CT Following Brain Metastatectomy: A Rare Diagnostic Pitfall.
FDG PET/CT is widely used in oncology but may occasionally show non-neoplastic hypermetabolic processes. We report incidental detection of probable ictal/peri-ictal hypermetabolism on follow-up FDG PET/CT in a…
Specific Instruments for Caregiving Competence Among Family Caregivers of Cancer Patients: A COSMIN Systematic Review of Psychometric Properties.
This systematic review evaluated the psychometric properties of instruments measuring caregiving competence among family caregivers of cancer patients. Seven studies were analyzed, focusing on three specific instruments.
AAML1831: A Phase III Trial Comparing Standard Induction Therapy With CPX-351 in De Novo Pediatric AML: A Report From the Children's Oncology Group.
The AAML1831 phase III trial assessed the efficacy of CPX-351 versus standard daunorubicin/cytarabine (DA) in children and young adults with newly diagnosed AML.
Izalontamab Brengitecan (Iza-Bren), a First-in-Class EGFR-HER3 Bispecific Antibody-Drug Conjugate in Extensive-Stage Small Cell Lung Cancer: Results From a Phase Ib Study.
This phase Ib multicenter study evaluated the efficacy and safety of izalontamab brengitecan (iza-bren) in patients with extensive-stage small cell lung cancer (ES-SCLC) who had progressed on prior therapies.
Rocbrutinib, a Highly Selective Fourth-Generation Covalent and Noncovalent BTK Inhibitor, in R/R Non-GCB DLBCL: Efficacy and Safety from a Phase I Study.
This phase I multicenter study evaluated the efficacy and safety of rocbrutinib, a fourth-generation BTK inhibitor, in 45 Chinese patients with relapsed or refractory non-GCB DLBCL.
Hemophagocytic lymphohistiocytosis and posterior reversible encephalopathy syndrome during BRAF/MEK inhibitor therapy following immune checkpoint blockade in metastatic melanoma: a case report.
A 61-year-old female with BRAF V600K-mutant metastatic melanoma developed hemophagocytic lymphohistiocytosis (HLH) after sequential treatment with immune checkpoint inhibitors and BRAF/MEK inhibitors.
Novel Germline ELP1 Splice-Acceptor Variant in NF1-Negative Optic Pathway Glioma: Expanding the Clinical Spectrum Associated With ELP1 Variation.
A 7-year-old boy presented with an optic pathway glioma without neurofibromatosis type 1 (NF1). Whole-exome sequencing revealed a novel germline ELP1 splice-acceptor variant, classified as likely pathogenic.
Fludarabine, Busulfan, Thiotepa, and Melphalan: A Novel Low-Toxicity Myeloablative Conditioning Regimen for Haploidentical HSCT in Children and Adolescents Aged ≥7 Years With Transfusion-Dependent β-Thalassemia.
This prospective clinical trial evaluated a novel low-toxicity myeloablative conditioning regimen (F-BMT) in 29 children and adolescents aged ≥7 years with transfusion-dependent β-thalassemia undergoing haploidentical…
Health risk assessment of inorganic arsenic: an umbrella review.
This umbrella review assessed health risks associated with inorganic arsenic (iAs) exposure by synthesizing 36 systematic reviews.
Circulating KIM-1 and survival outcomes in renal cell carcinoma: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the prognostic significance of circulating kidney injury molecule-1 (KIM-1) in renal cell carcinoma (RCC) across 2,415 patients from 7 studies.
Salvage Ex Situ Hepatectomy With Liver Autotransplantation for Recurrent Intraductal Papillary Neoplasm of the Bile Ducts (IPNB): A Case Report.
A 64-year-old woman with a history of left hepatectomy for intraductal papillary neoplasm of the bile ducts developed recurrent disease in the caudate lobe, closely associated with major vascular structures.
Total Neoadjuvant Therapy With Long-Course Radiotherapy Versus Chemoradiotherapy in High-Risk Locally Advanced Rectal Cancer (TNTCRT): A Multicenter, Randomized, Phase III Trial.
This multicenter, randomized, phase III trial evaluated total neoadjuvant therapy (TNT) with long-course radiotherapy (LCRT) versus conventional neoadjuvant chemoradiotherapy (nCRT) in patients with high-risk locally…
First Pediatric Use of Pegulicianine for Fluorescence-Guided Surgery in Li-Fraumeni-Associated Rhabdomyosarcoma.
A 4-year-old boy with Li-Fraumeni syndrome and a TP53 mutation presented with a supraclavicular mass, diagnosed as embryonal rhabdomyosarcoma with anaplastic features and positive margins.
Association Between Dinutuximab Beta Exposure and Post-End-of-Treatment Survival in Neuroblastoma: A Weighted Patient-Level Analysis of Three Clinical Studies.
This systematic review analyzed the association between dinutuximab beta (DB) exposure and post-end-of-treatment survival in neuroblastoma patients using data from three clinical trials.
Incidental Detection of Ovarian Hyperstimulation on FDG PET/CT After Oocyte Retrieval in a Breast Cancer Patient.
A breast cancer patient undergoing fertility preservation presented for staging with FDG PET/CT, which incidentally revealed bilateral polycystic ovarian enlargement with intense FDG uptake.
Breast implant-associated squamous cell carcinoma (BIA-SCC): Clinicopathologic analysis of two cases with radiologic-pathologic correlation and a review of the literature.
This report details two cases of breast implant-associated squamous cell carcinoma (BIA-SCC) in women in their 50s, presenting with breast pain and swelling one to two decades post-implantation.
Minimally invasive versus open surgery for gallbladder cancer: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the post-operative outcomes of minimally invasive surgery (MIS) versus open surgery for gallbladder cancer in 8,568 patients.
Clinical and Molecular Features of BAP1-Mutated Meningiomas: Case Series.
This report details three cases of BAP1-deficient meningiomas with distinct clinical outcomes. A 44-year-old woman with a somatic BAP1 mutation presented with recurrent spinal meningiomatosis despite low-grade…
Pleomorphic Implications in Gastrointestinal Stromal Tumors.
A patient with a pleomorphic gastrointestinal stromal tumor (GIST) in the stomach underwent a successful wedge resection. The tumor exhibited pleomorphism but did not show dedifferentiation, leading to a decision for a…
PARP Inhibitor Plus Androgen-receptor Signaling Inhibitor Versus the Same Inhibitor Alone in Homologous-Recombination-Repair-Altered Metastatic Prostate Cancer Across the Hormone-Sensitive and Castration-Resistant Continuum: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy of PARP inhibitors combined with androgen-receptor signaling inhibitors (ARSI) in 2343 men with homologous-recombination-repair-altered metastatic prostate…
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