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1998 articles
October 202624
Bimekizumab efficacy in male and female patients with axial spondyloarthritis: 52-week results from the phase 3 BE MOBILE trials.
This post hoc analysis of two phase 3 randomised trials assessed sex-based differences in bimekizumab response among patients with radiographic or non-radiographic axial spondyloarthritis.
Psychological Interventions Targeting Auditory Hallucinations in Persons With Psychotic Disorders: A Systematic Review and Meta-Analysis.
This systematic review and random-effects meta-analysis assessed randomised trials of psychological and psychosocial interventions targeting auditory hallucinations in adults with schizophrenia spectrum disorders.
Three versus six weeks of corticosteroids for mild immune-related pneumonitis: a randomized trial.
This randomized controlled trial evaluated the efficacy of a 3-week versus a 6-week corticosteroid taper in patients with mild immune-related pneumonitis.
Cross-Linked Chondroitin Sulfate Adhesion Barrier System in Open Rectal Resection: A Randomized Clinical Trial.
This multicenter, prospective, randomized, open-label trial with blinded endpoint assessment evaluated powdered cross-linked chondroitin sulfate (SI-449) in adults undergoing open rectal resection for rectal cancer.
Incisional Negative Pressure Wound Therapy for Prevention of Surgical Site Infection: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled 85 randomised clinical trials involving 16,980 adults with primarily closed surgical incisions to compare incisional negative pressure wound therapy (iNPWT) with standard…
Anterior Stromal Melt Following Implantation of a Large Size Corneal Allogenic Intrastromal Ring Segment (CAIRS).
To report delayed anterior stromal melt following corneal allogenic intrastromal ring segment (CAIRS) implantation in a patient without known systemic or ocular risk factors.
First-line biologic and targeted synthetic DMARDs versus methotrexate in early rheumatoid arthritis: a meta-analysis of remission outcomes.
This systematic review and meta-analysis of randomized trials compared initial biologic and targeted synthetic DMARDs (b/tsDMARDs), alone or with methotrexate, against methotrexate in methotrexate-naïve adults with…
Bilateral Costoclavicular Brachial Plexus Block for Closed Reduction of Bilateral Elbow Dislocation: A Case Report and Review of the Literature.
A 60-year-old man presented with bilateral posterolateral elbow dislocation following a road traffic accident. He underwent closed reduction and cast application under a bilateral ultrasound-guided costoclavicular…
Preoperative High-Dose Corticosteroids in Digestive Cancer Surgery: A Randomized Clinical Trial.
This multicenter, double-blind, placebo-controlled superiority randomized trial assessed whether preoperative high-dose corticosteroids improve outcomes after elective, curative-intent surgery for digestive cancer.
The Acceptability and Experiences of Participating in a Preoperative Intentional Weight-Loss Programme From Diagnosis to Surgery for Colorectal Cancer.
This qualitative study, embedded in the CARE randomised controlled trial, explored how patients with colorectal cancer experienced an intensive, dietitian-supported weight-loss programme between diagnosis and surgery.
Digital health interventions for psychological and cognitive care in cancer patients and caregivers: A RE-AIM-based systematic review.
This PRISMA-guided systematic review assessed the internal and external validity of digital interventions for psychological and cognitive concerns among people with cancer, caregivers, and family members, using the…
Development of HOPES Intervention for a Randomized Controlled Trial to Reduce the Perceived Stigma Among Women Living With HIV/AIDS in China.
This study developed and pilot-tested HOPES, a culturally grounded WeChat program intended to reduce HIV-related stigma among Chinese women living with HIV/AIDS.
Spontaneous splenic rupture in a patient with congenital factor XIII deficiency: A case report and literature review.
A 32-year-old man with congenital factor XIII deficiency presented with sudden abdominal pain and hypovolemic shock. Contrast-enhanced abdominal CT showed a large perisplenic hematoma, and surgery confirmed splenic…
Retrospective RNA Sequencing Reclassifies a Historical t(5;12) Eosinophilic Neoplasm From Presumed PDGFRB Rearrangement to ETV6::ACSL6.
A woman with a chronic eosinophilic myeloid neoplasm had a t(5;12) that raised suspicion of PDGFRB involvement, but contemporary testing did not identify a rearrangement and empiric imatinib produced no meaningful…
Trauma-related simultaneous asymmetric bilateral hip dislocation: A case report.
A 27-year-old man sustained simultaneous dislocations of both hips after high-energy trauma: the left hip was anteriorly dislocated and the right posteriorly.
Sutureless Epikeratophakia After Small Incision Lenticule Extraction: A Case Report to Correct Corneal Deformity.
An 18-year-old woman developed severe corneal thinning, with a residual stromal bed of 176 μm, and irregular hyperopic astigmatism in her left eye after a femtosecond laser malfunction during keratorefractive lenticule…
Longitudinal clinical outcomes after amyloid clearance in aducanumab phase 3 studies.
This exploratory analysis pooled participants from the randomized phase 3 ENGAGE and EMERGE aducanumab trials who entered a long-term extension or later redosing study.
Chatbot Intervention and Cancer Risk Knowledge in Adolescents and Young Adults With Cancer Predisposition: A Randomized Clinical Trial.
This multicentre randomized clinical trial evaluated whether a tailored electronic chatbot improved cancer-risk understanding among English-speaking adolescents and young adults aged 12 to 24 years with one of nine…
Effect of a Computer-Aided Device on Endoscopists' Biopsy Practice for Gastric Neoplasms: A Secondary Analysis of a Randomized Controlled Trial.
This secondary analysis of a randomized controlled trial compared AI-assisted with standard gastric screening, examining biopsy practice for documented lesions.
Neural correlates of acute task-related stress in humans: a systematic review and coordinate-based ALE meta-analysis.
This systematic review and ALE meta-analysis examined the neural correlates of acute task-related stress using task-based fMRI studies.
Updated Meta-Analysis of Left Atrial Appendage Closure Versus Oral Anticoagulation to Prevent Stroke in Atrial Fibrillation.
This systematic review and meta-analysis pooled six randomized controlled trials comparing percutaneous left atrial appendage closure (LAAC) with oral anticoagulation in 7028 patients with nonvalvular atrial…
Age at Iatrogenic Menopause and Cardiovascular Morbidity and Mortality: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the cardiovascular morbidity and mortality associated with iatrogenic menopause in 2,617,942 women.
Fibrin-Heparin-Coated Intracranial Stents as Salvage Therapy in Pediatric Focal Cerebral Arteriopathy-Inflammatory Type.
A 13-year-old boy presented with progressive arterial ischemic stroke due to focal cerebral arteriopathy inflammatory type.
Prevalence and Predictors of Depressive Symptom Trajectories in Older Adults: A Systematic Review.
This systematic review examined longitudinal patterns of depressive symptoms and their predictors among adults aged 60 years or older.
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