Trending archive
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433 articles
September 202624
Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews.
This systematic review and meta-analysis evaluated the efficacy of red blood cell (RBC) transfusions in treating or preventing complications in sickle cell disease (SCD) across 17 Cochrane reviews.
Expanded antigen-specific donor regulatory T cells for GVHD prevention.
This phase 1 clinical trial evaluated the safety and preliminary efficacy of expanded minor histocompatibility antigen (mHAg)-specific donor regulatory T cells (Treg) for preventing graft-versus-host disease (GVHD) in…
Venetoclax plus pediatric regimen in adolescents and adults with Ph-negative acute lymphoblastic leukemia.
This phase II multicenter trial evaluated the efficacy of venetoclax combined with pediatric-inspired chemotherapy in 167 adolescents and adults with newly diagnosed Philadelphia chromosome-negative acute lymphoblastic…
Population pharmacokinetic analysis of pirtobrutinib, a non-covalent BTK inhibitor, in patients with hematological malignancies from the Phase 1/2 BRUIN study.
This population pharmacokinetic analysis evaluated pirtobrutinib, a non-covalent BTK inhibitor, in 595 patients with hematological malignancies from the Phase 1/2 BRUIN study.
First Report on Remdesivir Use for the Treatment of Respiratory Syncytial Virus in Five Allogeneic Hematopoietic Cell Transplant Recipients.
Five allogeneic hematopoietic cell transplant recipients presented with lower respiratory tract infections caused by respiratory syncytial virus (RSV).
Oral vitamin C supplementation in patients with clonal cytopenia of undetermined significance or lower-risk myeloid malignancies: Results from EVITA, a phase 2 randomized, placebo-controlled trial.
The EVITA trial, a phase 2 randomized controlled trial, evaluated oral vitamin C supplementation in 109 adults with clonal cytopenia of undetermined significance or lower-risk myeloid malignancies.
Fulminant Secondary HLH Following EBV Reactivation in an Adult With Trisomy 21 After Teplizumab Treatment for Stage 2 Type 1 Diabetes.
A 44-year-old man with trisomy 21 and stage 2 type 1 diabetes developed respiratory, hepatic, and renal failure six days after completing a 14-day course of teplizumab.
API-CAT investigators' decisions on anticoagulation following extended treatment for cancer-associated thrombosis.
The API-CAT trial showed that reduced-dose apixaban was noninferior to full-dose for preventing recurrent venous thromboembolism in cancer patients.
Germline genomic testing to assess the suitability of stem cell donors in the treatment of haematological malignancy: clinical ethics commentary.
The increasing integration of genomic medicine into routine medical care brings to light issues of complexity and uncertainty in the interpretation of genetic variation.We describe a fictional case study based on our…
Robotic Splenectomy for Refractory Immune Thrombocytopenic Purpura.
A 40-year-old woman with a 4-year history of immune thrombocytopenic purpura, obesity, and Hashimoto thyroiditis presented with severe thrombocytopenia and abnormal uterine bleeding after failing medical therapy.
Acute myeloid leukemia arising in treated chronic lymphocytic leukemia/small lymphocytic lymphoma: a challenge in analysis of lineage relationship.
A 75-year-old female with a history of chronic lymphocytic leukemia/small lymphocytic lymphoma, previously treated with obinutuzumab and venetoclax, presented with acute myeloid leukemia characterized by…
Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia.
This Phase III randomized controlled trial evaluated the efficacy of blinatumomab compared to traditional chemotherapy in children with newly diagnosed high-risk B-cell acute lymphoblastic leukemia (ALL).
Haemolytic anaemia and thrombocytopenia following phenobarbital therapy for alcohol withdrawal.
A man in his 50s was admitted for alcohol withdrawal and developed acute anaemia and thrombocytopenia shortly after starting phenobarbital.
Orbital lymphoma presenting as preseptal cellulitis in a child with ataxia-telangiectasia.
A young child with ataxia-telangiectasia presented with left periorbital swelling, initially treated as a periorbital infection.
Evolving idiopathic multicentric Castleman disease with thrombocytopenia, anasarca, fever/hyperinflammation, renal dysfunction and organomegaly presenting with severe hypoalbuminaemia, serositis and bicytopenia before lymphadenopathy.
A man in his early 60s presented with abdominal symptoms, severe hypoalbuminaemia, thrombocytopenia, and marked inflammation, without evident lymphadenopathy.
First-line ibrutinib plus venetoclax for nonblastoid mantle cell lymphoma in patients ≥65 years old or with TP53 mutations.
The phase 3 SYMPATICO study evaluated the efficacy of first-line ibrutinib plus venetoclax in 78 patients with nonblastoid mantle cell lymphoma, specifically those aged ≥65 years or with TP53 mutations.
How I treat chemotherapy-induced thrombocytopenia with thrombopoietin receptor agonists.
The article discusses four cases of chemotherapy-induced thrombocytopenia (CIT), highlighting the complexities of managing this condition.
Clinical activity and safety of rilzabrutinib in patients with previously treated immune thrombocytopenia (LUNA3): results from the open-label period of a phase 3 trial.
The LUNA3 trial, a multicenter, randomized phase 3 study, evaluated the long-term efficacy and safety of rilzabrutinib in adults with previously treated immune thrombocytopenia.
Déjà vu.
A male in his mid-20s presented with fever, purpuric rash, neuropathy, marked eosinophilia, hepatic dysfunction, and extensive multisystem thrombosis.
Topical ruxolitinib for chronic cutaneous graft-versus-host disease: a single-centre, randomised, double-blind, intra-patient-controlled phase 2 trial.
This single-centre, randomised, double-blind, intra-patient-controlled phase 2 trial evaluated the efficacy and safety of topical ruxolitinib 1.5% cream in patients with chronic cutaneous graft-versus-host disease…
Immune Checkpoint Inhibitor-Associated Hemophagocytic Lymphohistiocytosis: Clinical Presentation and Outcomes in Three Patients.
Three patients receiving immune checkpoint inhibitors presented with diverse clinical symptoms indicative of systemic inflammation.
Early deep response to cilta-cel as 2nd CAR T-Cell therapy after CELMoD-based bridging for advanced multiple myeloma.
A 58-year-old male with high-risk IgA kappa multiple myeloma, previously treated with multiple therapies, received idecabtagene vicleucel as sixth-line treatment, achieving a deep response for about one year.
Incidence, Patterns, and Outcomes of Fungal Infections in Patients With Graft Versus Host Disease Requiring Systemic Steroids Following Allogeneic Hematopoietic Cell Transplantation: A Systematic Review and Meta Analysis.
This systematic review and meta-analysis pooled findings from four studies involving 1,141 patients with graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation who required systemic…
Chromosome 17p deletion in aplastic anaemia with paroxysmal nocturnal haemoglobinuria clone: a diagnostic challenge.
A 56-year-old female presented with recurrent aphthous ulcers and pancytopenia, showing severe anemia and thrombocytopenia.
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