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612 articles
October 202624
The entorhinal cortex atrophy score for diagnostic distinction between phases of the Alzheimer's disease continuum.
This systematic review assessed the Entorhinal Cortex Atrophy (ERICA) visual score for distinguishing subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer’s disease (AD) dementia.
Feasibility of a Co-Designed Personalized Cognitive Reablement Program Delivered via Digital Voice Assistants for Older Adults Living With Early-Stage Dementia or Mild Cognitive Impairment: Pilot Randomized Controlled Trial.
This nonblinded pilot randomized controlled trial assessed the feasibility and potential effectiveness of VOICE-COG, a personalized cognitive reablement program delivered through digital voice assistants, in adults aged…
Lesion Water Content on CT Predicts 12-Month Outcome and Modifies Thrombectomy Effect in Large-Core Stroke-A Secondary Analysis of the TENSION Trial.
This secondary analysis of the randomized TENSION trial examined whether CT-derived net water uptake (NWU) predicts 12-month outcomes and modifies thrombectomy effects in 198 patients with large-core ischemic stroke.
Protective effect of N-acetylcysteine on oxaliplatin-induced peripheral neuropathy in colorectal cancer: a randomized controlled trial.
This randomized controlled trial evaluated oral N-acetylcysteine (NAC) for preventing oxaliplatin-induced peripheral neuropathy in 46 patients with stage III or high-risk stage II colorectal cancer receiving adjuvant…
STN-SNr co-stimulation in Parkinson's disease: a systematic review and meta-analysis of motor and freezing-of-gait outcomes.
This systematic review and meta-analysis assessed whether adding substantia nigra pars reticulata stimulation to subthalamic nucleus deep brain stimulation improves motor function or freezing of gait in people with…
Agreement Between In-Person and Telephone Application of the Informant Questionnaire on Cognitive Decline in the Elderly.
This methodological study assessed agreement between in-person and telephone administration of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), completed by caregivers or family members of older…
Antidopaminergic Medications and Clinical Outcomes in Huntington Disease: Evidence From the PROOF-HD Placebo-Controlled Trial.
This post hoc analysis of the placebo arm of the randomized PROOF-HD trial examined associations between antidopaminergic medication (ADM) use and clinical outcomes in adults with Huntington disease.
Prediction of death by neurologic criteria in patients with non-traumatic acute brain injury: a systematic review and meta-analysis.
This systematic review and meta-analysis examined predictors of death by neurologic criteria (DNC) after non-traumatic acute brain injury.
Determining the minimal important difference of EQ-5D-5 L utility values in CIDP patients using data from a large clinical trial.
This analysis of data from the ADHERE randomized controlled trial estimated the minimal important difference (MID) in EQ-5D-5 L utility values for patients with chronic inflammatory demyelinating polyradiculoneuropathy…
Locus coeruleus abnormalities on neuromelanin-sensitive MRI in Parkinson's disease: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed locus coeruleus (LC) integrity on neuromelanin-sensitive MRI in Parkinson’s disease (PD), pooling independent comparisons with healthy controls using random-effects…
Efficacy and Safety of Argatroban as an Adjunct to Antiplatelet Therapy in Ischemic Stroke: An Updated Systematic Review and Meta-analysis.
This systematic review and meta-analysis assessed argatroban added to antiplatelet therapy versus control in acute ischemic stroke.
Effects of transcranial direct current stimulation on nicotine use disorder: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed transcranial direct current stimulation (tDCS) for smoking-related outcomes in people with nicotine use disorder.
Evaluating Improvement in Pain and Sensory Function When Using High-Frequency (10-kHz) Spinal Cord Stimulation in Individuals With Painful Diabetic Neuropathy: A Multicenter Randomized Controlled Trial (PDN-Sensory).
The multicenter randomized controlled PDN-Sensory trial evaluated 10-kHz spinal cord stimulation (SCS) plus conventional medical management (CMM) versus CMM alone in people with painful diabetic neuropathy.
Feasibility of a multidimensional interdisciplinary rehabilitation program for people with dementia and their informal primary caregivers - a randomized pilot trial with a caregiver focus.
This randomized pilot trial assessed the feasibility of a person-centred, interdisciplinary rehabilitation program for community-dwelling people with dementia that also provided education and support to informal…
Real-world safety and efficacy of lecanemab in the treatment of Alzheimer's disease: a systematic review and meta-analysis.
This systematic review and meta-analysis pooled real-world studies of lecanemab treatment in people with Alzheimer’s disease, including 37 studies.
Levetiracetam versus valproate for new-onset or previously treated but inadequately controlled epilepsy in children: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis compared levetiracetam with valproate in children aged 0–18 years with new-onset or inadequately controlled epilepsy.
The effect of seizure-free period on seizure recurrence following antiseizure medication withdrawal: a systematic review and meta-analysis.
This systematic review and random-effects meta-analysis examined whether the duration of seizure freedom before antiseizure medication (ASM) withdrawal is associated with subsequent seizure recurrence in people with…
Efficacy and safety of tolebrutinib in multiple sclerosis: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed tolebrutinib’s efficacy and safety in multiple sclerosis, drawing on four publications covering four randomised controlled trials and one long-term extension study.
Daily consumption of unsalted, skin-roasted peanuts beneficially affects regional brain insulin responsiveness in older adults: results of a longer-term randomized controlled trial.
This randomized, single-blind, controlled crossover trial examined whether peanut intake altered brain insulin responsiveness in 31 older adults (67 ± 4 years).
Association of dietary choline intake with cognitive decline and related outcomes: a systematic review and dose-response meta-analysis of observational studies.
This systematic review and dose-response meta-analysis examined observational evidence on dietary choline intake and cognitive decline or related outcomes.
Magnetic resonance imaging vs computed tomography for baseline imaging evaluation in acute basilar artery occlusion.
This post hoc analysis of the ATTENTION trial compared baseline MRI with CT for patient selection in acute basilar-artery occlusion.
Gene-based association analysis of depression risk among European ancestry Parkinson's disease patients.
This gene-based association analysis and meta-analysis examined common and low-frequency genetic variants related to depression among European-ancestry patients with Parkinson’s disease (PD) in three population-based…
Global cognitive and verbal episodic memory impairment in the post-acute phase of anti-nmdar encephalitis: a systematic review and meta-analysis with narrative synthesis.
This systematic review and meta-analysis examined standardized cognitive outcomes in adults with cell-based-assay-confirmed anti-NMDAR encephalitis during the post-acute or convalescent phase.
Genetic correlates of corticobasal degeneration: a systematic review and meta-analysis.
This PRISMA-guided systematic review and meta-analysis synthesized genetic association studies of corticobasal degeneration (CBD), including 22 studies published between 2001 and 2025.
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