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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

AllClinical ResearchCase Reports
FeaturedCase ReportNeurology

Neuronal intermediate filament neurologic autoimmunity in a patient with Merkel cell carcinoma receiving pembrolizumab.

Neurol SciOct 23, 2026Open access

A 55-year-old woman with recurrent stage IIIA Merkel cell carcinoma developed vertigo, gait instability, dysarthria, and persistent right hemifacial and cervical spasms after her second pembrolizumab dose.

Clinical pearl

With new neurologic symptoms during immune checkpoint inhibitor therapy, consider paraneoplastic NIF autoimmunity; an unremarkable brain MRI does not exclude it, and CSF antibody testing may support the diagnosis.

Read case

Also worth knowing

Case ReportPediatricsOpen access

Successful management of long-term venovenous ECMO for severe PARDS in a child with acute lymphoblastic leukemia.

A 5-year-old boy with low-risk B-cell acute lymphoblastic leukemia developed severe, refractory pediatric acute respiratory distress syndrome during induction therapy, with profound hypoxemia.

J Artif OrgansOct 13, 2026Read case
Case ReportOphthalmology

METASTATIC UROTHELIAL CARCINOMA OF THE BLADDER TO THE RETINA: A CLINICOPATHOLOGIC CORRELATION AND REVIEW OF THE LITERATURE.

A patient with urothelial carcinoma of the bladder had a large yellow-white lesion in the superotemporal retina of the left eye.

RetinaOct 21, 2026Read case
Case ReportInfectious Diseases

Fatal Rickettsia parkeri Rickettsiosis in Immunocompromised Pediatric Patient, Georgia, USA, 2025.

A 3-year-old boy in Georgia, USA, receiving chemotherapy for B-cell acute lymphoblastic leukemia was hospitalized with febrile neutropenia.

Emerg Infect DisOct 24, 2026Read case
Case ReportOncology (Medical)Open access

Successful treatment with BrECADD in a patient with Dubin-Johnson syndrome and classic Hodgkin lymphoma: a case report.

A 26-year-old man with advanced-stage classic Hodgkin lymphoma also had Dubin–Johnson syndrome (DJS) associated with a homozygous ABCC2 variant, c.2291G>A (p.Gly764Asp).

Cancer Chemother PharmacolOct 23, 2026Read case
Case ReportMedical GeneticsOpen access

Delayed diagnosis of MEN1 after kidney transplantation: unrecognized pre-transplant features and implications for clinical practice.

A 68-year-old man with end-stage renal disease underwent living-donor kidney transplantation and had persistent hypercalcemia afterward.

CEN Case RepOct 23, 2026Read case
Case ReportMedical Genetics

Pacak-Zhuang syndrome with EPAS1 p.Pro531Leu somatic variant: one case report and literature review.

A 4-year-old girl presented with recurrent hypertension, polycythemia and renal hilar masses. Imaging, biochemical testing and genetic analysis of paraffin-embedded tissue confirmed Pacak-Zhuang syndrome with a somatic…

HematologyOct 19, 2026Read case
Case ReportOncology (Medical)

From metastatic disease to no evidence of disease after conversion liver surgery in advanced gastric cancer with liver metastases: A case report.

A 54-year-old woman with initially unresectable, HER2-negative, pMMR-by-IHC, EBER-positive gastric cancer and synchronous liver metastases received tislelizumab-based chemotherapy, with regimen changes after suspected…

Hum Vaccin ImmunotherOct 22, 2026Read case
Case ReportOncology (Medical)

Tislelizumab-induced hyperamylasemia: Case report and safety analysis using the FAERS database.

A 69-year-old patient developed hyperamylasemia after six cycles of combination immunotherapy with pemetrexed, tislelizumab, and carboplatin. The authors attributed the elevated amylase to tislelizumab.

Int J Clin Pharmacol TherOct 16, 2026Read case
Case ReportRadiology (Diagnostic)Open access

Multimodal imaging features of nuclear protein in testis carcinoma of the submandibular gland: a case report.

A 32-year-old man presented with a painless left submandibular mass that enlarged from 2 cm to approximately 4 cm within 1 month, with new ipsilateral pharyngeal and periauricular pain.

J Med Case RepOct 16, 2026Read case
Case ReportGastroenterology

Acute colonic variceal bleeding treated with coil-assisted retrograde transvenous obliteration following atezolizumab-bevacizumab therapy for advanced hepatocellular carcinoma: A case report.

A 66-year-old man with alcohol-related cirrhosis and advanced hepatocellular carcinoma developed hematochezia the day after starting atezolizumab plus bevacizumab.

Medicine (Baltimore)Oct 16, 2026Read case
Case ReportPulmonology

Influenza A (H1N1) virus infection complicated by checkpoint inhibitor pneumonitis: A case report.

After neoadjuvant immunotherapy, a patient developed respiratory dysfunction and progressive pulmonary lesions. Imaging and positive influenza A (H1N1) testing, interpreted alongside the immunotherapy history and…

Medicine (Baltimore)Oct 16, 2026Read case

Showing 12 of 23 publications that cleared our clinical screen in the last 14 days.

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