Trending Now

Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

AllClinical ResearchCase Reports
FeaturedCase ReportNeurology

Clinicopathologic Evaluation of Amyloid Clearance in Alzheimer Disease.

JAMAOct 13, 2026Open access

A man in his 50s with mild cognitive impairment and the Alzheimer disease risk-associated p.R47H TREM2 variant received 30 doses of aducanumab (cumulative dose 280 mg/kg) over 4.5 years in a clinical trial.

Clinical pearl

In this case, downstream tau pathology and MRI-measured atrophy differed by regional residual amyloid burden; amyloid clearance was not uniform across cortical regions.

Read case

Also worth knowing

Case ReportHematologyOpen access

Myeloid neoplasm with PDGFRA rearrangement presenting in blast-phase with basophilia.

An adult man from Southern Africa presented with progressive fatigue. Blood morphology showed marked basophilia and 21% myeloblasts, with flow cytometry supporting a provisional diagnosis of acute myeloid leukaemia with…

J HematopOct 13, 2026Read case
Case ReportPathology (Anatomic & Clinical)

Primary intracranial sarcoma, DICER1-mutant: 5 cases highlighting variable clinical and molecular features.

The report describes five patients aged 6 to 40 years with primary intracranial sarcoma, DICER1-mutant, identified through methylation profiling and/or sequencing.

J Neuropathol Exp NeurolOct 20, 2026Read case
Case ReportOphthalmology

METASTATIC UROTHELIAL CARCINOMA OF THE BLADDER TO THE RETINA: A CLINICOPATHOLOGIC CORRELATION AND REVIEW OF THE LITERATURE.

A patient with urothelial carcinoma of the bladder had a large yellow-white lesion in the superotemporal retina of the left eye.

RetinaOct 21, 2026Read case
Case ReportPathology (Anatomic & Clinical)Open access

Co-occurrence of aortic dissection and polycystic kidney disease: a case report.

A 19-year-old Caucasian man with no known medical history collapsed during sexual intercourse and died. Post-mortem examination found hemopericardium and aortic dissection in association with polycystic kidney disease…

J Med Case RepOct 21, 2026Read case
Case ReportOphthalmology

Acquired Corneal Subepithelial Hypertrophy: First Ultrastructural Characterization by Transmission Electron Microscopy.

A 57-year-old man with prior penetrating keratoplasty for trauma and subsequent Descemet stripping automated endothelial keratoplasty developed progressive visual decline from a superficial corneal opacity.

Eye Contact LensOct 24, 2026Read case
Case ReportInfectious Diseases

Fatal Rickettsia parkeri Rickettsiosis in Immunocompromised Pediatric Patient, Georgia, USA, 2025.

A 3-year-old boy in Georgia, USA, receiving chemotherapy for B-cell acute lymphoblastic leukemia was hospitalized with febrile neutropenia.

Emerg Infect DisOct 24, 2026Read case
Case ReportOncology (Medical)Open access

Successful treatment with BrECADD in a patient with Dubin-Johnson syndrome and classic Hodgkin lymphoma: a case report.

A 26-year-old man with advanced-stage classic Hodgkin lymphoma also had Dubin–Johnson syndrome (DJS) associated with a homozygous ABCC2 variant, c.2291G>A (p.Gly764Asp).

Cancer Chemother PharmacolOct 23, 2026Read case
Case ReportNeurologyOpen access

Cerebrospinal fluid positive for SARS-CoV-2 associated with neurological manifestations and proteome alterations in a multiple myeloma patient.

A 67-year-old woman with multiple myeloma and recent exposure to a person with COVID-19 developed rapidly progressive dysarthria, dysphagia, and hypoesthesia without respiratory symptoms.

Neurol SciOct 19, 2026Read case
Case ReportMedical Genetics

Pacak-Zhuang syndrome with EPAS1 p.Pro531Leu somatic variant: one case report and literature review.

A 4-year-old girl presented with recurrent hypertension, polycythemia and renal hilar masses. Imaging, biochemical testing and genetic analysis of paraffin-embedded tissue confirmed Pacak-Zhuang syndrome with a somatic…

HematologyOct 19, 2026Read case
Case ReportNephrology

From inference to proof: nanopore sequencing confirms zoonotic Neisseria Zoodegmatis peritonitis after cat bite-related contamination in a patient on automated peritoneal dialysis.

A 90-year-old patient receiving automated peritoneal dialysis developed peritonitis after a cat bite damaged the transfer set. Empirical therapy produced only a partial response, followed by relapse.

J NephrolOct 22, 2026Read case
Case ReportNephrology

Unexpected finding of AA amyloidosis with novel genetic variants in the MEFV gene in patients undergoing kidney biopsy for proteinuria. A case series.

The report describes patients undergoing kidney biopsy for proteinuria in whom AA amyloidosis was identified, alongside MEFV gene variants.

J NephrolOct 22, 2026Read case

Showing 12 of 37 publications that cleared our clinical screen in the last 14 days.

Looking for an earlier article?Everything that has appeared in Trending is in the archive.

Stay updated for free

Get the 3 most interesting publications in one specialty each week.

Weekly email. Unsubscribe anytime.

Want this personalized?

Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.

  • Your specialties
  • Your filters and thresholds
  • Clinical Research + Case Reports, tuned separately
  • Automatic weekly delivery
  • Audio and text
Create my personalized digestSee plans

Prefer listening? Personalized audio digests are available with Pro.