Natural course of untreated obstructive sleep apnea in adults with coronary artery disease in the RICCADSA cohort.
Yüksel Peker, Mustafa Saygin, Yeliz Celik et al.
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In 30 seconds
This randomized controlled trial examined the natural course of untreated obstructive sleep apnea (OSA) in 119 adults with coronary artery disease (CAD) after revascularization. The study found that 61.3% of patients improved in OSA severity after one year, with a median apnea-hypopnea index (AHI) decreasing from 24.5 to 15.1 events/hour. Patients who improved had a significantly lower risk for major cardiovascular and cerebrovascular events (MACCEs).
Key findings
- 61.3% of patients improved in OSA severity after one year.
- Median AHI decreased from 24.5 to 15.1 events/hour.
- Patients with improved OSA had a lower risk for MACCEs (HR = 0.25).
- Control group had a median AHI of 4.4 events/hour after one year.
Why it matters
Understanding the trajectory of OSA in CAD patients post-revascularization is crucial for identifying those at risk for adverse cardiovascular events. This knowledge can guide targeted interventions and improve patient outcomes.