Effects of continuous positive airway pressure therapy on depression and anxiety in patients with obstructive sleep apnea with and without coronary heart disease.
Heart LungMay 2, 2026 (epub)
Liang Wang, Yu Zou, Jing Xu et al.
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In 30 seconds
This randomized controlled trial examined the effects of continuous positive airway pressure (CPAP) therapy on anxiety and depression in 72 patients with obstructive sleep apnea (OSA), both with and without coronary heart disease (CAD). After 12 months, patients receiving CPAP showed significant improvements in anxiety and depression scores compared to the control group, alongside reductions in inflammatory markers.
Key findings
- CPAP therapy significantly improved HADS anxiety and depression scores after 12 months compared to the control group.
- Levels of inflammatory markers, including WBC, neutrophils, CRP, IL-6, and PCT, decreased markedly in the CPAP group.
- The study highlights the importance of addressing emotional disorders in OSA patients, particularly those with CAD.
Why it matters
The findings underscore the potential of CPAP therapy not only to improve respiratory function but also to enhance mental health outcomes in patients with OSA, particularly those with comorbid conditions like CAD.