Continuous Positive Airway Pressure Versus Mandibular Advancement Devices Impact on Cardio-Metabolic Outcomes in Patients With Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
J Sleep ResJun 24, 2026 (epub)
AlMothana Manasrah, Mohammad Tanashat, Ramy Ghaly et al.
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In 30 seconds
This systematic review and meta-analysis of 14 randomized controlled trials involving 1241 patients with obstructive sleep apnea compared the cardiometabolic effects of continuous positive airway pressure (CPAP) and mandibular advancement devices (MAD). CPAP was found to significantly reduce low-density lipoprotein by 15.20 mg/dL and total cholesterol by 17.10 mg/dL, indicating a superior cardiometabolic profile over MAD.
Key findings
- CPAP reduced low-density lipoprotein by 15.20 mg/dL compared to MAD.
- Total cholesterol levels decreased by 17.10 mg/dL with CPAP versus MAD.
- CPAP led to a reduction in dipping diastolic blood pressure by 3.12 mmHg.
Why it matters
Understanding the comparative effects of CPAP and MAD on cardiometabolic outcomes is crucial for optimizing treatment strategies in patients with obstructive sleep apnea, particularly those at higher cardiovascular risk.