Alpha-Gal Syndrome-A Case Series of Successful Transcatheter Mammalian-Derived Aortic Valve Replacements.
Kian Lari, Shahzeb Leghari, Alan M Smeltz et al.
✦ AI-curated · Sources linked
Case in brief
Three patients with documented Alpha-gal syndrome (AGS) successfully underwent transcatheter aortic valve replacement (TAVR) using bovine or porcine-derived bioprosthetic valves. Preoperative evaluations by allergists were conducted, and two patients received no pharmacological pre-treatment. Intraoperative heparin was administered without adverse reactions, and all patients had uncomplicated postoperative courses with no allergic responses or valve deterioration over follow-up periods of 4 to 6 years.
Diagnostic / clinical pearl
Patients with Alpha-gal syndrome can safely undergo TAVR with mammalian-derived valves and heparin when appropriately evaluated and monitored, despite theoretical concerns about hypersensitivity reactions.
Why it matters
This case series highlights the importance of thorough preoperative assessment in managing patients with AGS undergoing cardiac procedures involving xenogeneic materials.