Prevalence and risk of cardiovascular events among people living with HIV: a meta-analysis.
Ann MedJul 20, 2026 (epub)
Shuqing Jin, Hongfei Liu, Xiyuan Song et al.
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In 30 seconds
This meta-analysis examined the prevalence and risk factors for cardiovascular events among 4,175,459 people living with HIV (PLWH). The study found a pooled prevalence of cardiovascular events at 6% (95% CI: 0.05-0.07), highlighting the significant burden of cardiovascular disease in this population and the influence of both traditional and HIV-related risk factors.
Key findings
- The pooled prevalence of cardiovascular events in PLWH was 6% (95% CI: 0.05-0.07).
- Older age, smoking, and antiretroviral therapy were linked to increased cardiovascular risk.
- Higher CD4+ counts (per 100 cells/mm3) were associated with lower cardiovascular risk.
- Subgroup analyses identified specific risk factors for myocardial infarction, arrhythmia, and stroke.
Why it matters
Understanding the prevalence and risk factors for cardiovascular events in PLWH is crucial for clinicians to implement early risk assessments and targeted interventions, potentially improving patient outcomes in this vulnerable population.