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1998 articles
October 202624
A Phase I Dose-Escalation/Expansion Study of Fractionated-Dose and Multiple-Cycle Anti-PSMA-Targeted α-Emitter 225Ac-J591 in Patients with Prostate Cancer.
This phase I dose-escalation and expansion study evaluated fractionated and repeated-cycle 225Ac-J591 in patients with progressive metastatic prostate cancer resistant to androgen pathway modulation.
Phase I Trial of IL13Rα2-Targeted CAR T-cell Therapy for Recurrent Malignant Glioma: Clinical Results and Pharmacokinetics.
This single-centre, open-label phase I trial assessed intravenous autologous IL13Rα2-targeted CAR T cells in adults with recurrent, IL13Rα2-expressing grade 3–4 gliomas after standard treatment.
Rilvegostomig for Metastatic Non-Small Cell Lung Cancer: A First-In-Human Phase I/II Clinical Study.
This first-in-human, multicenter, open-label phase I/II study evaluated rilvegostomig, a bispecific antibody targeting PD-1 and TIGIT, in patients with PD-L1-positive advanced or metastatic non-small cell lung cancer…
FDA Approval Summary: Retifanlimab for the Treatment of Adult Patients with Metastatic or Inoperable Locally Recurrent Squamous Cell Carcinoma of the Anal Canal.
This FDA approval summary describes evidence from POD1UM-303, a randomised trial in 308 patients with advanced squamous cell carcinoma of the anal canal (SCAC) and no prior systemic treatment for advanced disease, and…
FDA Approval Summary: Erdafitinib for FGFR3-Altered Locally Advanced or Metastatic Urothelial Carcinoma.
This FDA approval summary describes evidence supporting erdafitinib for patients with FGFR3-altered locally advanced or metastatic urothelial carcinoma that progressed during or after at least one systemic therapy.
Robotic-assisted conversion of unicompartmental to total knee arthroplasty: a systematic review.
This PRISMA-guided systematic review assessed robotic-assisted conversion of unicompartmental knee arthroplasty (UKA) to total knee arthroplasty (TKA).
Weight Loss Responses to Pharmacotherapy in Breast Cancer Survivors: Results from the Adaptive Nutrition and Exercise Weight Loss (A-NEW) Study.
This single-arm phase II study evaluated behavioral weight loss (BWL), with Contrave added for women with prior stage 0 to III breast cancer who lost less than 5% of their weight after two months.
The effects of sodium reduction and the DASH diet on ambulatory blood pressure: overall and race-stratified results from the DASH-Sodium trial.
This randomized feeding trial examined ambulatory blood pressure (ABP) responses to sodium reduction and the DASH diet in 335 participants, 58% of whom self-identified as Black.
Predicting neurodevelopmental delay among two-year-old infants in Northern Uganda.
This study developed and evaluated a risk-prediction model for neurodevelopmental delay among two-year-old children in Northern Uganda.
Assessing the Impact of Metacognitive Therapy on OCD Severity and Beliefs: A Three-Wave Multisite RCT With Panel Mediation Analysis.
This multisite, assessor-blinded randomized controlled trial compared 12 weekly sessions of individual metacognitive therapy (MCT) with documented treatment as usual (TAU) in 76 adults with OCD receiving outpatient care…
Brigimadlin versus Doxorubicin in Advanced Dedifferentiated Liposarcoma: Efficacy, Safety, and Translational Data from Brightline-1, a Randomized Phase II/III Trial.
Brightline-1 was a randomized phase II/III trial comparing first-line brigimadlin with doxorubicin in patients with MDM2-amplified, locally advanced or metastatic dedifferentiated liposarcoma.
Primary Hepatic Neuroendocrine Neoplasms: Systematic Review and Expert Pathologist Reappraisal Using the WHO 6th Edition Framework.
Primary hepatic neuroendocrine neoplasms (PHNENs) are exceedingly rare. Published evidence often lacks adequate clinicopathological support for a primary hepatic origin and uses inconsistent historical terminology.
Circulating Thymidine Kinase Activity Predicts Survival and Optimal Treatment Sequencing in BRAF-Mutated Metastatic Melanoma in the SECOMBIT Trial.
This randomized phase II trial biomarker analysis evaluated circulating thymidine kinase activity (TKa) in patients with BRAF V600-mutated metastatic melanoma receiving targeted therapy (TT), immune checkpoint…
A Systematic Review of Screen Time and Obesity in Children, Adolescents, and Young Adults: Sex-Specific Pathways and Implications for Public Health Interventions.
This systematic review synthesized evidence on screen time and obesity-related outcomes in children, adolescents, and young adults, examining possible sex-specific patterns.
Phase 2 Trial of Icotrokinra for Patients with Ulcerative Colitis.
This phase 2b, double-blind, randomized trial evaluated once-daily oral icotrokinra, an interleukin-23 receptor blocker, in adults with moderately to severely active ulcerative colitis.
Ponatinib-Blinatumomab or Imatinib-Chemotherapy for Adult Ph-Positive ALL.
This multicenter, phase 3 randomized trial compared frontline ponatinib plus blinatumomab with imatinib plus chemotherapy in adults with Philadelphia-positive acute lymphoblastic leukemia.
Immunogenicity of a Bivalent Typhoid-Paratyphoid Conjugate Vaccine Against Diverse Salmonella Paratyphi A Isolates.
This exploratory analysis of a phase 1 randomised controlled trial assessed O:2-specific IgA and IgM responses and serum bactericidal activity after two doses of a bivalent typhoid-paratyphoid conjugate vaccine.
Body weight following a multidomain lifestyle intervention in older adults at risk of dementia - A post-hoc analysis of the AgeWell.de-trial.
This post-hoc analysis of the cluster-randomized AgeWell.de trial examined body weight in 678 adults aged 60–77 years with overweight or obesity and at risk for dementia.
Dynamics of QuantiFERON-TB Gold Plus Results in a Large TB Preventive Treatment Trial Across 3 High-Burden HIV/TB Countries.
This longitudinal analysis of a randomized trial assessed serial QuantiFERON-TB Gold Plus (QFT-Plus) results in people with HIV enrolled in Ethiopia, Mozambique, and South Africa and assigned to three TB preventive…
Serum Virus-Neutralizing Antibody Titers in Clinical Trial Participants With and Without Immunocompromise Receiving Pemivibart, a Long-Acting Monoclonal Antibody for COVID-19.
This analysis of phase 3 CANOPY and phase 1 trial data examined measured and calculated serum virus-neutralizing antibody titers after pemivibart in participants with and without significant immunocompromise.
Behind the Sella: A Rare Case of Pituicytoma Mimicking a Pituitary Adenoma.
A 48-year-old man presented with symptoms of hypogonadism, headaches, and visual field defects. Testing showed hypogonadotropic hypogonadism and hyperprolactinemia, while MRI revealed a sellar-suprasellar mass initially…
A Prospective, Multicenter, Evaluator-Blind, Randomized, Comparator-Controlled Study of Belotero Intense (+), a Hyaluronic Acid Filler With Lidocaine, for Lip Augmentation.
This multicenter, evaluator-blind randomized comparator-controlled equivalence trial assessed Belotero Intense with lidocaine (BIL) for lip augmentation in patients with lip volume deficits, comparing it with Restylane…
Focal Epithelial Hyperplasia in a Somali Child: A Case Report and Review of Management with Topical Imiquimod.
An 8-year-old Somali girl had a 3.5-year history of asymptomatic, progressively increasing oral lesions. Examination showed multiple soft, flat-topped verrucous papules on the lower labial, buccal and lingual mucosa and…
Global Underutilization of Antiviral Therapy and Survival Outcomes in Hepatitis B Virus-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of 78 Studies and 68,243 Patients.
This systematic review and meta-analysis assessed antiviral use and its association with survival and hepatocellular carcinoma (HCC) recurrence in adults with HBV-related HCC.
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