Trending archive
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91 articles
October 202612
Local Delivery of Interferon-β1a for Respiratory Viral Infections: A Systematic Review.
This PRISMA-guided systematic review assessed locally delivered intranasal or inhaled interferon-β1a for respiratory viral infections, covering clinical trials and experimental evidence.
Metal Hypersensitivity Reactions Following Spinal Implants: A Systematic Review.
This systematic review examined clinical presentation, diagnostic approaches, and outcomes of metal hypersensitivity after spinal implant surgery in adults.
Paediatric Helicobacter pylori infection and allergic and inflammatory diseases: a contemporary systematic review with meta-analysis.
This systematic review and meta-analysis assessed recent evidence on Helicobacter pylori infection and allergic or immune-mediated diseases in children.
Efficacy and safety of subcutaneous efgartigimod with prednisone in moderate-to-severe pemphigus (ADDRESS): a global, phase III, randomised controlled, double-blind trial.
ADDRESS was a global, phase III, multicentre, randomised, double-blind, placebo-controlled trial of adults with newly diagnosed or relapsing moderate-to-severe pemphigus.
Approach to the patient with APS-1/APECED.
This article presents five cases of autoimmune polyendocrine syndrome type 1 (APS-1/APECED), a disorder caused by impaired immune tolerance and typically associated with biallelic AIRE variants.
Serum Virus-Neutralizing Antibody Titers in Clinical Trial Participants With and Without Immunocompromise Receiving Pemivibart, a Long-Acting Monoclonal Antibody for COVID-19.
This analysis of phase 3 CANOPY and phase 1 trial data examined measured and calculated serum virus-neutralizing antibody titers after pemivibart in participants with and without significant immunocompromise.
Food-Associated Kounis Syndrome: Clinical Spectrum and Diagnostic Considerations from a Case Report and Systematic Qualitative Synthesis of Published Cases.
The supplied abstract does not describe an individual patient’s presentation, diagnostic findings, or outcome. It reports a qualitative synthesis of published food-associated Kounis syndrome cases: 53 patients across 50…
Oral deucrictibant for on-demand treatment of hereditary angioedema attacks: a phase 3, multicentre, randomised, double-blind, placebo-controlled crossover trial.
RAPIDe-3 was a phase 3, multicentre, randomised, double-blind, placebo-controlled crossover trial of oral deucrictibant for on-demand treatment of hereditary angioedema attacks.
Adult-Onset Henoch-Schönlein Purpura Triggered by Isotretinoin with Persistent Polyarthritis and Isolated Cutaneous-Gastrointestinal Involvement: A Case Report.
A 30-year-old woman developed palpable purpura, abdominal pain, and symmetric polyarthritis three weeks after starting isotretinoin.
Anaphylaxis Following Intravenous Methylprednisolone Sodium Succinate: A Case Report.
A 45-year-old woman with rheumatoid arthritis developed generalized pruritic erythema and raised lesions, dyspnea, hypoxemia, bradycardia, and reduced consciousness within 5 minutes of starting intravenous…
Suspected allergic bronchopulmonary candidiasis in a patient with concurrent multidrug-resistant bacterial pneumonia: A case report.
A 70-year-old man with a history of hypertension and cerebral infarction presented with sudden right limb weakness and was diagnosed with hemorrhagic cerebral infarction.
Treatment of Multifood Allergy With Omalizumab or Multiallergen Oral Immunotherapy: A Randomized Clinical Trial.
This randomized clinical trial compared the efficacy of omalizumab versus multiallergen oral immunotherapy (MOIT) in treating multifood allergies in participants aged 1 to 55 years.
September 202612
Short-term nasal decongestant as bridge therapy with intranasal corticosteroids in children with persistent allergic rhinitis: A randomized controlled trial.
This prospective, open-label, single-centre randomised trial compared intranasal corticosteroid (INS) alone with INS plus five days of oxymetazoline in children aged 4–17 years with moderate-to-severe persistent…
Asthma Intervention with Residential Ventilation and Air Cleaner (AIRVAC) Study: A 4-arm parallel-group randomized controlled trial protocol.
The AIRVAC study is a 4-arm parallel-group randomized controlled trial evaluating the long-term effectiveness of energy recovery ventilators and portable air cleaners in improving asthma outcomes among children and…
Levels of IgG subclasses 1-4 in BT595, a 10% IVIG: A sub-analysis of a clinical trial.
This multicenter, open-label clinical trial evaluated the pharmacokinetics of IgG subclasses in patients with primary immunodeficiency receiving 10% IVIG BT595.
Mild Phenotype in Functionally Validated STAT1 Gain-of-Function Disease Due to a Novel DNA-Binding Variant.
A case report describes four patients with STAT1 gain-of-function disease, focusing on three related individuals with a novel p.Leu400Pro variant.
Anaphylaxis to both pegfilgrastim and sargramostim in a patient with diffuse large B-cell lymphoma.
A woman in her early 60s with stage 3A diffuse large B-cell lymphoma experienced anaphylaxis to pegfilgrastim after her first cycle of R-CHOP chemotherapy, presenting with syncope and severe hypotension.
Complicated allergic fungal rhinosinusitis: diagnostic complexities and management strategies.
A man in his 60s presented with diplopia, headache, and facial numbness, leading to a diagnosis of bilateral abducens nerve palsy and partial right third nerve palsy.
Novel TRAC variant causing autosomal recessive TCR-alpha/beta deficient immunodeficiency 7.
Monozygotic twin brothers presented in early infancy with severe, recurrent diarrhoea and profound T-cell lymphopenia. Immunological assessment revealed significantly reduced immunoglobulins and very low CD3+, CD4+, and…
Prenatal maternal stress and the risk of allergic rhinitis in offspring: A systematic review and meta-analysis.
This systematic review and meta-analysis examined whether maternal stress during pregnancy is associated with allergic rhinitis (AR) in offspring. It pooled findings from 9 studies involving 40,630 participants.
Trial of a Maternal Diet Rich in Eggs and Peanuts to Reduce Infant Allergy.
This multicenter randomized controlled trial investigated the effect of a maternal diet rich in eggs and peanuts on the development of food allergies in infants.
IL-2 mutein selectively expands thymic memory Tregs with increased transendocytosis in healthy participants.
This randomized, single-ascending-dose trial in healthy human participants examined how the IL-2 mutein MK-6194 affects regulatory T-cell (Treg) subsets and function.
Déjà vu.
A male in his mid-20s presented with fever, purpuric rash, neuropathy, marked eosinophilia, hepatic dysfunction, and extensive multisystem thrombosis.
Effect of repeated exposure to an identical multi-user virtual reality anaphylaxis scenario on paramedic trainee performance: a randomized controlled trial.
This randomized controlled trial evaluated the impact of repeated exposure to a virtual reality (VR) anaphylaxis scenario on the performance of 125 paramedic trainees.
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