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1998 articles
October 202624
Leveraging Longitudinal DBS Recordings to Probe Pharmacological Mechanisms: Investigating the Role of Orexin Antagonists on Extended Amygdala Activity.
A patient with severe, treatment-refractory obsessive-compulsive disorder and comorbid insomnia had beta activity recorded longitudinally from the bed nucleus of the stria terminalis (BNST) using implanted deep brain…
Exercise to enhance antipsychotic effectiveness and mitigate metabolic harm: systematic review and meta-analysis.
This systematic review and meta-analysis pooled randomised controlled trials of supervised exercise in adults receiving antipsychotic medication for psychotic disorders.
Maternal circulating cytokine and chemokine levels during pregnancy and risk of autism spectrum disorder in offspring: A systematic review and meta-analysis.
This systematic review and meta-analysis examined whether maternal blood cytokine and chemokine levels during pregnancy were associated with autism in offspring, drawing on seven human observational studies.
Minimally Invasive Versus Sternotomy in Redo Mitral Valve Surgery: Short- and Long-Term Outcomes with Meta-Regression and Time-to-Event Analysis.
This meta-analysis compared minimally invasive mitral valve surgery (MI-MVS) with sternotomy for redo surgery in adults. It included 15 studies and 3457 patients, pooling perioperative outcomes and reconstructing…
Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.
This individual participant data meta-analysis examined amyloid PET scans from 49,227 participants across 53 studies to establish Centiloid positivity cutoffs for Alzheimer disease diagnosis.
Parenchymal Injury Caused by Complete Migration of a Bone of Japanese Horse Mackerel Within the Pancreatic Uncinate Process Through a Duodenal Diverticulum, Resulting in Sepsis and Multiple Pyogenic Liver Abscesses.
A 79-year-old man developed abdominal pain and fever three days after ingesting grilled Japanese horse mackerel. Imaging revealed a fish bone fully migrated into the pancreatic uncus through a duodenal diverticulum…
Genome-wide meta-analysis dissects the genetic basis and health implications of circulating taurine.
This genome-wide meta-analysis examined the genetic basis of circulating taurine levels in 36,490 European individuals. The study identified six common and two rare genetic loci associated with taurine levels and…
Safe electrophysiology-guided resection of an epileptogenic non-exophytic hamartoma at the floor of the fourth ventricle in a child.
Hamartoma of the floor of fourth ventricle (HFFV) is an extremely rare entity known to be causing focal movement disorders in children.
Associations between duration of status epilepticus and clinical outcomes in adults: a systematic review.
This systematic review examined the relationship between the duration of status epilepticus (SE) and clinical outcomes in adults, analyzing 43 studies.
Early-onset VEXAS syndrome mimicking orbital cellulitis and successfully treated with allogeneic hematopoietic stem cell transplantation.
A 25-year-old male presented with recurrent fever, weight loss, arthralgia, and symptoms resembling orbital cellulitis. Imaging revealed orbital soft tissue inflammation, while laboratory tests showed macrocytic anemia…
Iron or Multiple Micronutrient Powder Supplements With Malaria Chemoprevention in Rural Malawian Children: The IRMA Randomized Clinical Trial.
This randomized clinical trial evaluated the effects of iron supplements combined with malaria chemoprevention on cognitive outcomes in 6-month-old infants in rural Malawi.
Cardiovascular safety in middle-aged and older men under testosterone replacement therapy: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the cardiovascular safety of testosterone replacement therapy (TRT) in middle-aged and older men, analyzing data from 31 randomized-controlled trials involving 9,437…
Outcomes after middle meningeal artery embolization using coils alone for chronic subdural hematoma: A systematic review and single-arm meta-analysis.
This systematic review and single-arm meta-analysis evaluated the outcomes of coil-only middle meningeal artery embolization (MMAE) for chronic subdural hematoma (cSDH) in 397 patients across 10 studies.
Ventriculo-arterial coupling in acute heart failure: prognostic and therapeutic insights - a systematic review and meta-analysis of multivariable-adjusted data.
This systematic review and meta-analysis evaluated the prognostic significance of non-invasive ventricular-arterial coupling (VAC) in 36,989 patients hospitalized with acute heart failure (AHF).
GLP-1 receptor agonists for obstructive sleep apnea: a meta-analysis of randomized controlled trials.
This meta-analysis of randomized controlled trials evaluated the efficacy and safety of GLP-1 receptor agonists in adults with moderate-to-severe obstructive sleep apnea (OSA).
A High-Energy Military Femoral Fracture With Multidrug-Resistant Infection: A Case Report.
A 37-year-old military man presented with a high-energy femoral fracture complicated by a multidrug-resistant infection. After multiple debridement procedures and the use of an external fixation device, he underwent…
A Systematic Review of Stem Cell Secretome-Derived Exosomes for Neuropathic Pain: Therapeutic Mechanisms and Translational Potential.
This systematic review assessed the therapeutic mechanisms and potential of stem cell secretome-derived exosomes for neuropathic pain (NP) in preclinical and clinical studies.
Early structured rehabilitation following open retromuscular incisional hernia repair: a prospective randomized controlled trial.
This randomized controlled trial evaluated the impact of structured early rehabilitation on functional recovery after open retromuscular incisional hernia repair in 30 adults.
Digital Twin-Assisted Risk Disclosure in Adults Undergoing Elective Bronchoscopy: Multicenter Randomized Controlled Trial.
This multicenter randomized controlled trial evaluated the impact of digital twin-assisted risk disclosure on prebronchoscopy anxiety and postbronchoscopy satisfaction in adults undergoing elective bronchoscopy.
Reliability of Childhood Autism Rating Scale, Second Edition, Assessments Using Telepsychiatry for Children With Neurodevelopmental Disorders and Their Caregivers: Randomized Feasibility Study.
This randomized feasibility study evaluated the interrater reliability of the Childhood Autism Rating Scale, Second Edition (CARS2) between telepsychiatry and face-to-face assessments in 73 children aged 6 to 17 with…
TRICALS risk score augments but cannot replace neurofilament as a prognostic biomarker in ALS.
This randomized controlled trial evaluated the TRICALS risk score as a prognostic tool in amyotrophic lateral sclerosis (ALS) using data from the MIROCALS trial (n = 220).
Efficacy and safety of switching to once-daily oral doravirine plus raltegravir in virologically suppressed people with HIV-1: a randomized, open-label, multicentre phase 2 study (DORAL).
DORAL was a multicentre, open-label, randomized phase II trial in virologically suppressed adults with HIV-1 on stable antiretroviral therapy, without prior doravirine exposure or raltegravir resistance.
Presumed transdermal superwarfarin toxicity in a pest control worker.
A man in his early 60s presented with dyspnoea and a 2-3 month history of spontaneous mucocutaneous bleeding. Laboratory tests showed unmeasurably elevated INR and activated partial thromboplastin time.
Same-day diagnosis and robotic resection of rare primary pulmonary melanoma: a robotic bronchoscopy-guided approach.
A man in his 70s presented with a lingular pulmonary nodule suspicious for non-small cell lung cancer. He underwent robotic navigation bronchoscopy for biopsy, which was followed by robotic-assisted thoracic surgery.
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