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1998 articles

October 202624

Clinical ResearchOphthalmology

Microperimetry Sensitivity Changes at the Functional Transition Zone and at the EZ Margins in X-Linked Retinitis Pigmentosa Treated With Gene Therapy.

This post-hoc analysis of the randomized Skyline trial examined how photoreceptor ellipsoid-zone (EZ) structure related to microperimetry sensitivity in eyes with X-linked retinitis pigmentosa treated with gene therapy.

Transl Vis Sci TechnolOct 5, 2026Read summary
Clinical ResearchCardiology

Mechanical Thrombectomy Versus Anticoagulation Alone in Intermediate-High Risk PE: Improved Functional 90-Day Outcomes in STORM-PE RCT.

STORM-PE was a multicentre randomised trial comparing computer-assisted vacuum thrombectomy (CAVT) plus anticoagulation with anticoagulation alone in 100 patients with acute intermediate-high-risk pulmonary embolism.

JACC Cardiovasc IntervOct 5, 2026Read summary
Clinical ResearchAnesthesiology

Repeated remimazolam sedation for interstitial brachytherapy in cervical cancer: a randomized controlled trial.

This randomized controlled trial evaluated the safety and efficacy of repeated remimazolam sedation compared to propofol in 100 patients with cervical cancer undergoing interstitial brachytherapy.

Ann MedOct 4, 2026Read summary
Clinical ResearchHematologyOpen access

N-acetylcysteine mouthwash for prevention of oral mucositis in hematopoietic cell transplant recipients: a double-blind randomized controlled trial.

This double-blind randomized controlled trial evaluated the efficacy of N-acetylcysteine (NAC) mouthwash in preventing oral mucositis (OM) in 106 hematopoietic cell transplant (HCT) recipients.

Support Care CancerOct 4, 2026Read summary
Case ReportOtolaryngology (ENT)

Image-Guided Cervicotomy and Recurrent Laryngeal Nerve Reinnervation in Zone II Glass Neck Trauma: A Case Report.

A 45-year-old woman with penetrating neck trauma from glass fragments presented hemodynamically stable, without airway compromise. Imaging revealed multiple retained glass foreign bodies but no major vascular injuries.

Am J Case RepOct 4, 2026Read case
Clinical ResearchHematologyOpen access

Interference of iron deficiency in glycated hemoglobin testing and its clinical implications: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the impact of iron deficiency anemia (IDA) and latent iron deficiency (LID) on glycated hemoglobin (HbA1c) concentrations.

Biochem Med (Zagreb)Oct 4, 2026Read summary
Clinical ResearchRadiology (Diagnostic)

Improvement of image quality and diagnostic accuracy of novel ferumoxytol-enhanced magnetic resonance coronary angiography: compared to non-contrast enhanced imaging.

This retrospective analysis of a prospective clinical trial compared ferumoxytol-enhanced with non-contrast coronary magnetic resonance angiography (CMRA) in 29 patients, using invasive coronary angiography as the…

Eur J RadiolOct 4, 2026Read summary
Clinical ResearchNeurosurgeryOpen access

Predictors and causes of 30-day failure after shunt placement in pediatric hydrocephalus: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated 30-day failure rates of ventriculoperitoneal (VP) shunts in pediatric hydrocephalus, analyzing data from 11,596 patients.

Childs Nerv SystOct 3, 2026Read summary
Clinical ResearchCardiologyOpen access

Metabolomic biomarkers and metabolic remodelling in genetically characterised hypertrophic cardiomyopathy: a systematic review.

This systematic review examined metabolomic evidence in 1511 participants with genetically characterised hypertrophic cardiomyopathy (HCM).

MetabolomicsOct 3, 2026Read summary
Clinical ResearchGeriatricsOpen access

Should I drink water or wine? Impacts of online nutritional counseling on the alcohol consumption of elderly individuals with mild cognitive impairment : Secondary Data Analysis from the RCT "BrainFit-Nutrition".

This secondary data analysis from a randomized controlled trial evaluated the effects of nutritional counseling on alcohol consumption in 189 elderly individuals with mild cognitive impairment (MCI) over 12 months.

BMC Public HealthOct 3, 2026Read summary
Clinical ResearchNeurosurgeryOpen access

Comparison of video-based and presentation-based self-directed instruction for learning basic neuroangiography.

This randomized controlled trial compared video-based and presentation-based self-directed instruction for teaching basic neuroangiography skills to 20 participants with varying prior experience.

BMC Med EducOct 3, 2026Read summary
Case ReportEmergency Medicine

Exertional Rhabdomyolysis With Moderate Creatine Kinase Elevation and Marked Transaminase Elevation but Preserved Synthetic Function: A Case Report.

A 43-year-old man presented with fatigue, nausea, and myalgia following a 3000-m run. Laboratory tests revealed moderate creatine kinase (CK) elevation at 2828 U/L alongside significantly elevated transaminases: AST at…

Am J Case RepOct 3, 2026Read case
Clinical ResearchOncology (Medical)Open access

Boesenbergia rotunda extract-based mucoadhesive mouth gargle for chemoradiation-induced oral mucositis: A prospective randomized controlled study.

This randomized controlled trial evaluated the efficacy of a Boesenbergia rotunda extract-based mouth gargle in managing chemoradiation-induced oral mucositis in head and neck cancer patients.

Support Care CancerOct 3, 2026Read summary
Clinical ResearchOncology (Medical)Open access

The impact of intratumor heterogeneity on outcome and resistance to therapy in primary breast cancer: a systematic review.

This systematic review examines the impact of intratumor heterogeneity (ITH) on chemotherapy resistance in primary breast cancer, analyzing 12 studies across various tumor subtypes.

Med OncolOct 3, 2026Read summary
Clinical ResearchUrologyOpen access

Robot-assisted versus non-robotic partial nephrectomy for completely endophytic renal tumors: a systematic review and meta-analysis.

This systematic review and meta-analysis compared robot-assisted partial nephrectomy (RAPN) with laparoscopic (LPN) and open partial nephrectomy (OPN) for completely endophytic renal tumors (CERTs) in 896 patients.

J Robot SurgOct 3, 2026Read summary
Clinical ResearchNeurologyOpen access

Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Cognitive Outcome after Stroke: A Systematic Review.

This systematic review examined the association between the BDNF Val66Met polymorphism and cognitive outcomes in 2,494 adults post-stroke.

Transl Stroke ResOct 3, 2026Read summary
Clinical ResearchGeneral SurgeryOpen access

The learning curve of robotic pancreatoduodenectomy: a systematic review of learning curve assessment methodologies, proficiency thresholds, training pathways and clinical outcomes.

This systematic review evaluated the learning curve of robotic pancreatoduodenectomy (RPD) across 42 studies, focusing on methodologies, proficiency thresholds, and outcomes.

J Robot SurgOct 3, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Prevalence of osteoporosis and low bone mass in men with prostate cancer: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the prevalence of osteoporosis and low bone mass in 91,913 men with prostate cancer (PCa).

Support Care CancerOct 3, 2026Read summary
Clinical ResearchNeurologyOpen access

The Therapeutic Potential of MicroRNAs Delivered By Mesenchymal Stem Cells in Parkinson's Disease, Alzheimer's Disease, and Stroke: A Systematic Review of Preclinical Studies.

This systematic review evaluated 37 preclinical studies on the therapeutic potential of mesenchymal stem cells (MSCs) and their derived microRNAs (miRNAs) in Parkinson's disease, Alzheimer's disease, and stroke.

Mol NeurobiolOct 3, 2026Read summary
Clinical ResearchPediatrics

Haemodynamic and neurophysiological assessments for 2-year outcome prediction in neonates with hypoxic-ischaemic encephalopathy treated with therapeutic hypothermia: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the prognostic accuracy of amplitude-integrated electroencephalography (aEEG), cerebral near-infrared spectroscopy (cNIRS), and targeted neonatal echocardiography…

BMJ Paediatr OpenOct 3, 2026Read summary
Clinical ResearchGeneral SurgeryOpen access

Learning curves in robotic and laparoscopic colorectal surgery: a systematic review.

This systematic review evaluated learning curves in laparoscopic and robotic colorectal surgery, analyzing 114 studies with 167 learning-curve analyses.

J Robot SurgOct 3, 2026Read summary
Clinical ResearchOncology (Medical)

Trial-specific absolute disease-free survival effects of postoperative PD-1/PD-L1 blockade after complete resection of NSCLC: A systematic review.

This systematic review estimated absolute disease-free survival (DFS) effects of postoperative single-agent PD-1/PD-L1 blockade after complete resection of non-small-cell lung cancer.

Lung CancerOct 3, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Effects of exercise and educational programs on long-term quality of life, anxiety, and depression in breast cancer survivors: an exploratory secondary analysis of the Setouchi breast project-10 randomized controlled trial.

This exploratory secondary analysis of a randomized controlled trial examined exercise and education for 342 patients with stage 0–III breast cancer within one year of completing treatment.

Breast CancerOct 3, 2026Read summary
Clinical ResearchNeurology

HD-tACS at 40 Hz improves consciousness and brain connectivity in prolonged disorders of consciousness: a randomized sham-controlled clinical trial.

This randomized, sham-controlled clinical trial evaluated 40 Hz and 4 Hz high-definition transcranial alternating current stimulation (HD-tACS) in 60 patients with prolonged disorders of consciousness.

NeuroimageOct 3, 2026Read summary

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