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1998 articles

October 202624

Clinical ResearchPhysical Medicine & Rehabilitation

AI-Enabled Telerehabilitation for Chronic Nonspecific Neck Pain: Multicenter Randomized Controlled Trial.

This multicenter, prospective, parallel-group randomized noninferiority trial compared AI-enabled home telerehabilitation with exercise-matched outpatient rehabilitation in people with chronic nonspecific neck pain…

JMIR Form ResOct 15, 2026Read summary
Clinical ResearchOncology (Medical)

Circulating Thymidine Kinase Activity Predicts Survival and Optimal Treatment Sequencing in BRAF-Mutated Metastatic Melanoma in the SECOMBIT Trial.

This randomized phase II trial biomarker analysis evaluated circulating thymidine kinase activity (TKa) in patients with BRAF V600-mutated metastatic melanoma receiving targeted therapy (TT), immune checkpoint…

Clin Cancer ResOct 15, 2026Read summary
Clinical ResearchUrologyOpen access

Association of immune checkpoint-related polymorphisms in PD-1, PD-L1, and CTLA-4 genes with susceptibility to genitourinary cancer: a meta-analysis.

This meta-analysis pooled evidence from 16 case-control studies examining six single-nucleotide polymorphisms in PD-1, PD-L1, and CTLA-4 genes and susceptibility to genitourinary cancers, including urothelial, renal…

Immunol ResOct 15, 2026Read summary
Clinical ResearchOncology (Medical)Open access

FDA Approval Summary: Erdafitinib for FGFR3-Altered Locally Advanced or Metastatic Urothelial Carcinoma.

This FDA approval summary describes evidence supporting erdafitinib for patients with FGFR3-altered locally advanced or metastatic urothelial carcinoma that progressed during or after at least one systemic therapy.

Clin Cancer ResOct 15, 2026Read summary
Clinical ResearchObstetrics & Gynecology

Impact of structured sexual health training incorporating standardised patients on health professions students' sexual health communication competence: A single-blind randomised controlled trial in Tanzania.

This single-blind, parallel-group randomised controlled trial evaluated structured sexual health training incorporating standardised patients (SPs) among undergraduate medical and nursing students at a university in…

PLoS OneOct 15, 2026Read summary
Clinical ResearchOncology (Medical)Open access

A Meta-Analysis on Outcomes of Zanidatamab Plus Chemotherapy in Patients with Advanced HER2-positive Gastroesophageal Adenocarcinoma.

This meta-analysis pooled outcomes from three clinical trials involving 685 patients with advanced HER2-positive gastroesophageal adenocarcinoma treated first-line with zanidatamab plus chemotherapy, with or without…

J Gastrointest CancerOct 15, 2026Read summary
Case ReportCardiothoracic SurgeryOpen access

Optimization of Anticoagulation Strategy During Cardiopulmonary Bypass in Neonates with Congenital Heart Disease: A Randomized Controlled Trial.

Neonatal hemostatic immaturity complicates anticoagulation during cardiopulmonary bypass (CPB). Current practice largely follows the strategy of 400 U/kg from adult protocols, as neonatal-specific guidelines and…

Drug Des Devel TherOct 15, 2026Read case
Clinical ResearchOncology (Medical)

Long-term Results of Multiantigen Stimulated Cell Therapy I, Alone or in Combination with Chemotherapy, as First-line Maintenance Therapy in Advanced Sarcoma: A Multicenter, Phase I Trial.

This multicenter, phase I trial evaluated multiantigen stimulated cell therapy I (MASCT-I), alone or with ifosfamide, as first-line maintenance therapy in 31 patients with advanced sarcoma whose disease was controlled…

Clin Cancer ResOct 15, 2026Read summary
Clinical ResearchNeurology

Key Predictors of Cerebral Vasospasm Following Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis examined observational evidence on factors associated with cerebral vasospasm after subarachnoid hemorrhage (SAH).

West J Nurs ResOct 15, 2026Read summary
Clinical ResearchPreventive Medicine / Public Health

Acceptability and Feasibility of an Islamic Faith-Based Smoking Cessation Intervention Delivered via WhatsApp for Muslim Smokers in Saudi Arabia: Pilot Randomized Controlled Trial.

This two-arm pilot randomized controlled trial assessed the feasibility, acceptability, and preliminary outcomes of a 21-day Islamic faith-based smoking cessation intervention delivered by WhatsApp to adult Muslim…

JMIR Form ResOct 15, 2026Read summary
Clinical ResearchCardiologyOpen access

Immune checkpoint inhibitor-related myocarditis, myositis, and myasthenia gravis overlap syndrome: a single-center case series and systematic review.

The aim of our study was to evaluate the clinical, diagnostic, therapeutic, and prognostic features of immune checkpoint inhibitor-related myocarditis, myositis, and myasthenia gravis overlap syndrome (IM3OS).

Support Care CancerOct 15, 2026Read summary
Clinical ResearchOncology (Medical)

Rilvegostomig for Metastatic Non-Small Cell Lung Cancer: A First-In-Human Phase I/II Clinical Study.

This first-in-human, multicenter, open-label phase I/II study evaluated rilvegostomig, a bispecific antibody targeting PD-1 and TIGIT, in patients with PD-L1-positive advanced or metastatic non-small cell lung cancer…

Clin Cancer ResOct 15, 2026Read summary
Clinical ResearchOncology (Medical)Open access

A Phase I Dose-Escalation/Expansion Study of Fractionated-Dose and Multiple-Cycle Anti-PSMA-Targeted α-Emitter 225Ac-J591 in Patients with Prostate Cancer.

This phase I dose-escalation and expansion study evaluated fractionated and repeated-cycle 225Ac-J591 in patients with progressive metastatic prostate cancer resistant to androgen pathway modulation.

Clin Cancer ResOct 15, 2026Read summary
Clinical ResearchVascular Surgery

The Moderating Effects of Race and Ethnicity on a Motivational Interviewing Intervention for Improving Physical Health Among Patients With Peripheral Artery Disease: Secondary Analysis of a Pilot Randomized Trial.

This secondary analysis of a pilot randomized trial examined whether social determinants of health modified motivational interviewing (MI) effects on walking distance and weight among community-dwelling adults with…

JMIR Form ResOct 15, 2026Read summary
Clinical ResearchCardiology

Efficacy and safety of baxdrostat in the management of uncontrolled hypertension: a systematic review and meta-analysis.

This systematic review and meta-analysis assessed baxdrostat versus placebo in randomized controlled trials involving patients with uncontrolled hypertension.

Am J HypertensOct 15, 2026Read summary
Case ReportNeurologyOpen access

Intracranial metastasis as a mimic of amyloid-related imaging abnormalities.

A 79-year-old woman with biomarker-confirmed Alzheimer’s disease developed progressive vasogenic edema while receiving lecanemab.

Neurol SciOct 15, 2026Read case
Clinical ResearchOncology (Medical)

AI-Based Pathology Classifier Predicts Sensitivity to Enzalutamide in Metastatic Hormone-Sensitive Prostate Cancer: A Biomarker Analysis of the ENZAMET Trial.

This prespecified biomarker analysis of the randomised ENZAMET trial assessed whether a locked artificial intelligence pathology image classifier (APIC) identified differential overall-survival benefit from enzalutamide…

Clin Cancer ResOct 15, 2026Read summary
Clinical ResearchNeurologyOpen access

Peripheral Nerve Stimulation for Essential Tremor: a Systematic Review and Meta-Analysis of Effectiveness and Safety.

This systematic review and meta-analysis assessed peripheral nerve stimulation (PNS), including transcutaneous afferent patterned stimulation and transcutaneous peripheral nerve stimulation, for essential tremor.

Curr Pain Headache RepOct 15, 2026Read summary
Clinical ResearchOncology (Medical)

Multicenter Phase I Study of Triapine in Combination with [177Lu]Lutetium-Dotatate in Patients with Well-Differentiated Neuroendocrine Tumors (ETCTN 10388).

This multicenter phase I dose-escalation and dose-expansion study evaluated [177Lu]lutetium-dotatate plus oral triapine in patients with well-differentiated gastroenteropancreatic neuroendocrine tumors.

Clin Cancer ResOct 15, 2026Read summary
Case ReportPediatricsOpen access

Giant Cystic Lymphangioma of the Transverse Mesocolon in a 7-Year-Old Child: A Case Report.

A 7-year-old girl presented with several weeks of vomiting, abdominal pain and progressive distension. Examination found a large abdominal mass; laboratory results were unremarkable.

Int Med Case Rep JOct 15, 2026Read case
Clinical ResearchHematology

Prognostic value of measuring LSC frequency in AML: a systematic review and meta-analysis.

This systematic review and reconstructed individual patient data meta-analysis assessed whether leukemia stem cell (LSC) measurements predict outcomes in patients with acute myeloid leukemia at diagnosis or in…

Blood AdvOct 15, 2026Read summary
Clinical ResearchInfectious Diseases

Safety and immunogenicity of a first-generation modified vaccinia virus Ankara-vectored SARS-CoV-2 vaccine candidate with mRNA-based booster vaccination: A phase 1 trial.

This phase 1 trial assessed safety and immune responses to the MVA-vectored SARS-CoV-2 vaccine MVA-SARS-2-S in 30 healthy, SARS-CoV-2-naive adults given two doses 28 days apart, with six-month follow-up.

Hum Vaccin ImmunotherOct 15, 2026Read summary
Clinical ResearchGeriatricsOpen access

Body weight following a multidomain lifestyle intervention in older adults at risk of dementia - A post-hoc analysis of the AgeWell.de-trial.

This post-hoc analysis of the cluster-randomized AgeWell.de trial examined body weight in 678 adults aged 60–77 years with overweight or obesity and at risk for dementia.

BMC GeriatrOct 15, 2026Read summary
Case ReportOncology (Medical)

Primary Intermammary Breast Carcinoma Presenting With Direct Sternal Invasion: A Diagnostic Pitfall of Standard Screening Mammography.

An 85-year-old woman noticed a hard, non-tender sternal nodule despite an unremarkable screening mammogram 8 months earlier.

Am J Case RepOct 15, 2026Read case

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