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2000 articles
October 202624
Changes in ectopic lipids, insulin sensitivity, and beta cell function after a low-fat vegan diet in adults with type 2 diabetes: a 16-week single-arm clinical trial.
This 16-week, single-arm clinical trial examined changes in ectopic lipids, insulin sensitivity, advanced glycation end products, and beta-cell function in 25 adults with type 2 diabetes following an ad libitum low-fat…
A Lynch syndrome patient with multiple cancers who was found to have a novel pathogenic variant generating aberrant splicing of MLH1.
A Japanese woman with colorectal, gastric, and endometrial cancers was found to carry the germline MLH1 variant c.545G>T (p.Arg182Met), initially classified by a clinical testing laboratory as a variant of uncertain…
A multicenter randomized phase III trial of weekly cisplatin chemoradiotherapy versus radiotherapy in elderly patients with head and neck squamous cell carcinoma unfit for high-dose cisplatin: JCOG2405 (ELDER-WEEKLY).
JCOG2405 (ELDER-WEEKLY) is a planned multicenter, randomized phase III trial comparing radiotherapy plus weekly cisplatin (40 mg/m2) with radiotherapy alone in patients aged ≥70 years with locally advanced head and neck…
Values, preferences, and treatment burden for initiation of GLP-1 receptor agonists, SGLT-2 inhibitors, tirzepatide, and finerenone in adults with type 2 diabetes: systematic review.
This systematic review synthesised quantitative and qualitative evidence on treatment values, preferences, and perceived burden among adults with type 2 diabetes considering GLP-1 receptor agonists, SGLT-2 inhibitors…
Real-World Effectiveness of AI-Enabled Clinical Decision Support in Primary Care: Systematic Review.
This systematic review synthesized real-world evaluations of clinician-facing AI-enabled clinical decision support in primary and ambulatory care, covering studies published from 2011 through 2025.
Accidental Bottle Cap Ingestion in an Adult in a Resource-Limited Setting: A Case Report.
A 53-year-old man presented after accidentally swallowing a bottle top while opening a pressurized reused beverage bottle with his teeth. He had drooling, dysphagia, throat pain, and a foreign-body sensation.
Effects of Blood Pressure Lowering by Hematoma Location in Acute Intracerebral Hemorrhage.
This pooled individual-patient analysis of five international randomised controlled trials examined whether hematoma location modifies the effect of early intensive blood pressure lowering in acute intracerebral…
Astrocytic and Axonal Injury Biomarkers in AQP4 Antibody-Positive NMOSD: Insights From PREVENT and CHAMPION-NMOSD.
This biomarker analysis used samples from the phase 3 PREVENT and CHAMPION-NMOSD trials to assess serum GFAP and NfL in people with AQP4 antibody-positive NMOSD receiving eculizumab or ravulizumab.
Extensive Aplasia Cutis Congenita with Calvarial Defect and Superior Sagittal Sinus Exposure in a Term Neonate: A Case Report of Successful Healing with Conservative Management.
A term male neonate presented with an approximately 4 × 4 cm midline frontoparietal scalp defect involving the skin and calvarium, with the superior sagittal sinus exposed.
Advanced Rheumatic Heart Disease Complicated by Pregnancy, Mitral Valve Disease, Pulmonary Hypertension, and Left Atrial Thrombus: A Multidisciplinary Case Report from Resource-Limited Settings.
A 27-year-old woman in late pregnancy presented with progressive dyspnea, palpitations, leg swelling, cough, and fatigue. Echocardiography showed an enlarged left atrium, moderate mitral stenosis with mild regurgitation…
Genotype-informed docosahexaenoic acid dosing based on the FADS Indel to reduce preterm and prolonged gestation: A secondary analysis of the ADORE randomized trial.
This post hoc secondary analysis of the multicentre ADORE randomised trial examined whether FADS Indel genotype modified the association between DHA dose and gestational outcomes.
Pancreatic Tuberculosis Mimicking Pancreatic Cancer in a Young Immunocompetent Man: A Case Report and Literature Review.
A 34-year-old HIV-seronegative Afghan man had a year of intermittent epigastric pain, nausea, and vomiting. CT showed a 57×30 mm multiloculated hypoattenuating mass in the pancreatic head without biliary dilation; serum…
Histologically Confirmed Brain Metastasis Arising From Giant Cell Tumor of Bone: an Uncommon Entity and a Challenging Condition.
A 39-year-old patient with no significant medical history had a giant cell tumor of bone (GCTB) in the left distal femur, treated with preoperative denosumab and resection with prosthetic reconstruction.
Clinical and Electrophysiological Heterogeneity of Orthostatic Tremor: An Individual Patient Data Analysis.
Orthostatic tremor (OT) is traditionally classified using tremor frequency and the presence of associated neurological signs.
Association Between a Hybrid Video-Guided Multicomponent Exercise Program With Staff Assistance and Free-Living Gait in Older Adults With Knee and Low Back Pain: Secondary Analysis of a Randomized Controlled Trial.
This secondary analysis of a randomized controlled trial examined whether a 12-week hybrid exercise program affected free-living walking in 59 community-dwelling adults aged 65 years or older with mild to moderate knee…
Prevalence of mental health outcomes among trans and gender diverse adults: a global systematic review and meta-analysis.
This global systematic review and meta-analysis pooled mental health outcome estimates among trans and gender diverse adults. It included 207 studies with 134,071 participants across 52 countries.
Case Report: Atypical femoral fractures in adult-onset hypophosphatasia treated with low-dose asfotase alfa and adjunctive teriparatide therapy.
A 52-year-old woman presented with progressive pain and bilateral atypical femoral fractures. Low alkaline phosphatase, markedly elevated pyridoxal 5'-phosphate, prior metatarsal fracture, premature tooth loss, and…
Ilioinguinal-Transversus Abdominis Plane (I-TAP) Block with Liposomal Bupivacaine for Analgesia After Cesarean Delivery: A Randomized Controlled Trial.
Cesarean delivery is frequently associated with suboptimal postoperative analgesia. While PROSPECT guidelines recommend transversus abdominis plane (TAP) block for post-cesarean analgesia, conventional TAP block may…
Varicella zoster virus meningitis with a dermatomal rash in immunocompetent hosts: a systematic review and novel case report.
A 44-year-old immunocompetent man presented with fever, severe headache, and a right-sided vesicular rash in the C4-C5 dermatomes. He was initially misdiagnosed with a tick-borne illness.
Intravascular imaging guidance in complex PCI: a meta-analysis of randomized trials across complex lesion subsets.
This meta-analysis pooled randomized trials comparing intravascular imaging (IVI)-guided with angiography-guided PCI in patients with trial-defined complex PCI or extractable complex-lesion cohorts.
Efficacy of technology-based psychosocial interventions on quality of life and psychological outcomes in adolescent and young adult survivors of childhood cancer: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis pooled randomized controlled trials of technology-based psychosocial interventions for adolescent and young adult survivors of childhood cancer.
Adverse childhood experiences, cognitive outcomes, and frailty in older adults: a systematic review and meta-analysis.
This systematic review and meta-analysis examined associations between adverse childhood experiences (ACEs) and frailty or cognitive outcomes in middle-aged and older adults.
Trigeminal sensory neuropathy developing as a late complication after the treatment of surgically induced necrotizing scleritis following pterygium surgery: a case report and literature review.
A 31-year-old woman developed right-eye irritation, reduced vision, and photophobia after bilateral pterygium surgery. Examination showed melting of the conjunctival autograft with exposed sclera and a visible choroidal…
Association between complement de-escalation and prognosis in sepsis: A systematic review and meta-analysis.
This systematic review and meta-analysis examined whether reduced complement activation after treatment was associated with prognosis in patients with sepsis. Eleven studies were included.
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