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2000 articles
October 202624
Prospective controlled study of the recombinant zoster vaccine in autoimmune rheumatic disease: robust seroconversion despite intravenous cyclophosphamide.
This subanalysis of a prospective, randomized, placebo-controlled trial assessed recombinant zoster vaccine (RZV) responses in patients with autoimmune rheumatic disease receiving intravenous cyclophosphamide (IVCYC)…
T-cell-redirecting therapies in early relapsed multiple myeloma: a systematic review and network meta-analysis.
This systematic review and network meta-analysis compared T-cell-redirecting regimens in randomized phase 3 trials involving patients with multiple myeloma after at least one prior line.
Probable vestibular paroxysmia mimicking benign paroxysmal positional vertigo of the superior semicircular canal in the presence of a neurovascular conflict: a case report and review of the literature.
A 52-year-old woman presented with positional vertigo and was initially diagnosed with right superior semicircular canal benign paroxysmal positional vertigo (BPPV).
Effect of a Single Subanesthetic Dose of Esketamine on Gastrointestinal Recovery After Laparoscopic Colorectal Cancer Surgery: A Randomized, Outcome-Assessor-Blinded, Placebo-Controlled Trial.
Postoperative gastrointestinal dysfunction (POGD) and Postoperative gastrointestinal intolerance (POGI) remain a critical challenge in abdominal surgery, particularly for colorectal cancer patients undergoing…
Digital health technologies for the prevention and management of urinary tract infections in menopausal women: A systematic review.
This systematic review synthesised evidence on digital technologies for preventing or managing urinary tract infections in menopausal women.
Safety, Efficacy, and Immunogenicity of a Multivalent Adjuvanted Staphylococcus aureus Vaccine in Adults With Recent Skin and Soft Tissue Infections: An Observer-Blind, Randomized, Placebo-Controlled, Multinational Phase 1/2 Trial.
This observer-blind, randomized, placebo-controlled phase 1/2 trial evaluated a five-antigen Staphylococcus aureus vaccine with AS01E adjuvant in adults, including 194 participants aged 18–64 years with a recent S.
Short- versus long-course antibiotic therapy in non-severe CAP in children: a systematic review and meta-analysis.
This systematic review and meta-analysis compared short-course (≤ 5 days) with longer (> 5 days) antibiotic therapy for non-severe community-acquired pneumonia in immunocompetent children.
Chemotherapy backbone and outcomes of immune checkpoint inhibitor combinations across solid tumors: a pan-tumor network meta-analysis.
This systematic review and network meta-analysis examined phase II–III randomised trials comparing first-line immune checkpoint inhibitor (ICI) plus chemotherapy with chemotherapy alone across solid tumours, assessing…
Acrokeratosis paraneoplastica (Bazex syndrome): a systematic review and quantitative analysis of 106 cases.
Acrokeratosis paraneoplastica (Bazex syndrome) is an obligate paraneoplastic dermatosis characterized by symmetrical acral psoriasiform lesions and nail dystrophy.
Dose response relationship of medical cannabis and symptom control in patients with pancreatic cancer: an analysis of the CANPAN trial.
This analysis of the CANPAN pilot waitlist-control randomized trial examined cannabis use, patient-reported outcome completion, and THC dose-response among 32 cannabis-naïve patients with newly diagnosed locally…
Safety and Immunogenicity of the Live-Attenuated Quadrivalent Dengue Vaccine V181 Compared With Butantan-DV Among Healthy Adults in Brazil: A Randomized, Double-Blind, Phase 2 Trial.
This randomized, double-blind, active-comparator phase 2 trial compared the safety and immunogenicity of single-dose quadrivalent dengue vaccines V181 and Butantan-DV in healthy adults in Brazil.
Successful treatment of hairy cell leukemia with TP53 abnormality using cladribine combined with low-dose rituximab: a case report and literature review.
An elderly man with classical hairy cell leukemia (HCL) had BRAF V600E positivity, a TP53 deletion detected by fluorescence in situ hybridization, and bone marrow fibrosis.
Immunogenicity and Safety of Co-administration of Adjuvanted Respiratory Syncytial Virus Prefusion F Protein Vaccine With 20-Valent Pneumococcal Conjugate Vaccine in Adults Aged ≥60 Years: A Randomized, Non-inferiority Trial.
This phase III, open-label, randomized non-inferiority trial compared concomitant versus one-month-apart administration of adjuvanted RSV prefusion F protein vaccine (RSVPreF3) and 20-valent pneumococcal conjugate…
Case report: successful use of repotrectinib in a ROS1 fusion-positive lung adenocarcinoma patient with severe renal insufficiency and prior tyrosine kinase inhibitor treatment failure.
A 69-year-old woman with advanced lung adenocarcinoma harboring an SDC4–ROS1 fusion had bilateral pulmonary lesions, mediastinal lymphadenopathy, and pleural effusions.
Multiple Sclerosis During Pregnancy and the Postpartum Period: Diagnostic and Multidisciplinary Challenges in Two Cases.
The report describes two pregnant women with progressive focal neurological symptoms and brain MRI abnormalities concerning for central nervous system demyelination.
EACTS Expert Consensus Document on aortic valve repair and valve-sparing aortic root replacement procedures.
This EACTS Expert Consensus Document critically reviews evidence on aortic valve repair and valve-sparing aortic root replacement for aortic regurgitation and proximal thoracic aortic aneurysms across age groups.
Anxiety and Depression in Athletes of Different Levels Without Current Injury: A Systematic Review With Meta-Analyses.
This systematic review and random-effects meta-analysis examined anxiety and depression in athletes across competitive levels, including those without current injury.
Systematic Review and Meta-Analyses of Time-Use, Productivity, and Labor Outcomes Among Unpaid Cancer Caregivers.
This systematic review and meta-analysis pooled evidence on time use and labor outcomes among unpaid caregivers of adults with cancer.
Sunitinib in Patients With Various Solid Tumors With FGFR1 / 2 Alterations: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study.
This phase II basket trial evaluated sunitinib in patients with advanced solid tumours and FGFR1 or FGFR2 alterations who had no remaining standard treatment options. Histology-specific cohorts were pooled by alteration.
Managing 7-Hydroxymitragynine Use Disorder with Buprenorphine-Naloxone.
A patient who had used kratom to stop illicit opioids developed tolerance and transitioned to 7-hydroxymitragynine, believing the plant-derived product was safe.
Efficacy of direct-acting antiviral regimens for acute HCV infection: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed interferon-free dual direct-acting antiviral regimens for acute or recently acquired HCV infection.
Fosfomycin as Oral Transition Therapy Versus Continued Intravenous β-Lactams for Complicated Urinary Tract Infections Caused by Extended-Spectrum β-Lactamase-Producing Enterobacterales: A Multicenter, Open-Label, Randomized Controlled Trial.
This multicenter, open-label randomized noninferiority trial compared oral fosfomycin transition therapy with continued intravenous carbapenem or β-lactam/β-lactamase inhibitor therapy in hospitalized adults with…
Multidimensional Poverty and Implementation Reach of Household Contact Tracing for Tuberculosis in South Africa: Analysis of a Randomized Trial.
This analysis of a cluster-randomized trial in South Africa examined whether household multidimensional poverty was associated with the reach of household contact tracing (HHCT) for tuberculosis.
Dose- and modality-specific effects of exercise on BDNF and depression in middle-aged and older adults with mild cognitive impairment: A Bayesian network meta-analysis.
This Bayesian network dose-response meta-analysis examined randomized controlled trials of exercise in adults aged 50 years or older with mild cognitive impairment (MCI), assessing peripheral brain-derived neurotrophic…
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