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1999 articles
October 202624
Characterizing vaginal misoprostol induction in individuals with and without severe obesity.
This secondary analysis of the vaginal misoprostol arm of a cluster-randomized trial compared term inductions in individuals with BMI < 40 versus ≥ 40 kg/m².
Clinical outcomes of low versus high intensity laser therapy in patients with subacute carpal tunnel syndrome: A randomized, single-blinded, controlled trial.
This single-blinded randomized controlled trial compared high-intensity laser therapy (HILT), low-level laser therapy (LLLT), and sham laser, each alongside physiotherapy, in 69 people with electromyography- and…
Severe growth retardation in Dent disease: a case report of a novel OCRL variant.
A 12-year-old boy with marked short stature and poor weight gain had low-molecular-weight proteinuria, haematuria, hypercalciuria and bilateral nephrocalcinosis, with normal renal function and no relevant family…
A Single Exercise Session Elicits a Transient Kynurenine Metabolic Signature in Health and Disease: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined acute changes in circulating tryptophan (TRP) and kynurenine-pathway metabolites after a single exercise session.
Volumetric discordance between ¹⁸F-FET-PET/MRI and MRI-based radiotherapy target volumes in high-grade glioma: a prospective pilot study (FETSMaRT).
This prospective pilot study enrolled 30 patients with WHO grade 3 or 4 high-grade glioma receiving postoperative radiotherapy.
Modified LIFT via a Lateral Approach Versus Standard LIFT for Transsphincteric Anal Fistula: A Prospective Randomized Study.
This single-center prospective randomized study compared modified ligation of the intersphincteric fistula tract (LIFT) via a lateral approach with standard LIFT in adults with MRI-confirmed transsphincteric anal…
Routine versus postoperative CRP/CT guided selective diverting ileostomy after laparoscopic low anterior resection for rectal cancer: a comparative randomized controlled trial.
This randomized controlled trial compared postoperative CRP/CT-guided selective diversion with routine diverting ileostomy in 200 patients with stage II or III middle or lower rectal cancer undergoing laparoscopic low…
Anxiety in patients with cancer and emergency department use: a systematic review.
This systematic review examined whether anxiety is associated with subsequent emergency department (ED) use among adults with cancer.
The Use of Cannabidiol in Cutaneous Wound Healing: A Systematic Review.
This qualitative systematic review assessed cannabidiol (CBD) for cutaneous wound healing, including in vivo studies and clinical trials identified through searches of seven databases. Six studies were included.
Effect of a Subanesthetic Dose of Esketamine on Postoperative Sleep Disturbance After Oocyte Retrieval Under Intravenous Anesthesia: A Randomized Controlled Trial.
This randomized, double-blind, placebo-controlled trial assessed whether intravenous esketamine reduces postoperative sleep disturbance (PSD) in women undergoing oocyte retrieval with intravenous anesthesia.
Patient-reported and caregiver-reported outcomes in refractory ascites secondary to cirrhosis: A systematic review and meta-analysis.
This systematic review and meta-analysis examined patient- and caregiver-reported outcomes in refractory ascites (RA) secondary to advanced chronic liver disease.
Case Report: Veno-Arteriovenous Extracorporeal Membrane Oxygenation for Management of Pheochromocytoma-Induced Cardiac Arrest in a Post-Partum Patient.
A 34-year-old woman, two days postpartum, was admitted to intensive care with hypertensive crisis and respiratory failure. CT showed an 18-cm left adrenal mass suspicious for pheochromocytoma.
Early extracranial dissemination with prolonged survival in IDH-wildtype glioblastoma: case study and comprehensive literature review.
A 65-year-old woman with IDH-wildtype, MGMT-methylated glioblastoma presented with seizures, right hemiplegia, and expressive aphasia.
Recurrent Primary Angiosarcoma of the Breast: Challenges and Pitfalls in a Case Report.
A patient presented with a breast lesion and skin involvement; histopathology and immunohistochemistry confirmed low- to intermediate-grade primary breast angiosarcoma.
Impact of body composition on clinical outcomes in patients with hepatocellular carcinoma: A systematic review and meta-analysis.
This systematic review and meta-analysis examined associations between body composition and outcomes in patients with hepatocellular carcinoma (HCC), across curative, locoregional, systemic, and mixed treatment…
Ramadan Fasting in Chronic Heart Failure: A Systematic Review.
This systematic review assessed clinical studies of Ramadan fasting in people with chronic heart failure. Searches of PubMed, Scopus, and Web of Science identified seven eligible studies from 137 records; most were…
Multiple-Staged Versus Single-Stage Surgical Excision for the Reconstruction of Congenital Melanocytic Nevi: A Meta-Analysis of Efficacy and Safety.
This meta-analysis compared multiple-staged with single-stage excision and reconstruction for congenital melanocytic nevi (CMN). It pooled seven retrospective cohort or clinical controlled studies involving 578 patients.
Antibiotic-Loaded Hydrogel, Calcium Bead, and Cement in Periprosthetic Joint Infection Following Hip-Knee Arthroplasty: A Systematic Review and Meta-Analysis of Commercially Available Products.
This systematic review and meta-analysis compared defensive antibacterial coating (DAC), calcium sulfate beads, and antibiotic-loaded bone cement for preventing or managing periprosthetic joint infection after total hip…
Preclinical and first-in-human evaluation of VG-3927/SAR448851, an oral small-molecule TREM2 agonist for Alzheimer's disease.
This study evaluated VG-3927, an oral, CNS-penetrant small-molecule TREM2 agonist, using preclinical models and a first-in-human randomized, double-blind, placebo-controlled phase 1 trial.
Aberrant splicing caused by a homozygous AK2 c.498 + 1G > A variant in a patient with reticular dysgenesis and concurrent B-cell acute lymphoblastic leukemia.
A boy with reticular dysgenesis (RD), a severe immunodeficiency associated with biallelic AK2 loss of function, was also diagnosed with B-cell acute lymphoblastic leukemia (B-ALL).
Fecal microbiota transplantation for the treatment of neurogenic rosacea: protocol of a randomized, blinded, placebo-controlled explorer study.
This publication describes the protocol for a single-center, randomized, double-blind, placebo-controlled exploratory trial of fecal microbiota transplantation (FMT) in patients with neurogenic rosacea, a phenotype…
Immediate effects of spinal manipulation, exercise therapy, and open-label placebo on lifting performance and pain in individuals with chronic non-specific back pain: a motion laboratory-based crossover randomized controlled trial.
This motion-laboratory crossover randomised controlled trial examined immediate effects of spinal manipulation (SMT), exercise therapy (ET), and open-label placebo (OLP) on lifting and pain in 50 individuals with…
Targeting an IL-17/IL-36 pathogenic hub in hidradenitis suppurativa with a bispecific antibody.
This phase I/II proof-of-concept clinical trial evaluated HB0043, a bispecific antibody targeting IL-17A and IL-36R, in patients with severe, tunnel-dominant Hurley Stage III hidradenitis suppurativa.
Surgery to treat autonomic dysreflexia due to cubital tunnel syndrome in cervical spinal cord injury: a case report.
A 74-year-old woman with remote C6 spinal cord injury (AIS B) developed recurrent autonomic dysreflexia episodes that had not responded to standard measures.
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