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2000 articles
October 202624
A Systematic Review of Stem Cell Secretome-Derived Exosomes for Neuropathic Pain: Therapeutic Mechanisms and Translational Potential.
This systematic review assessed the therapeutic mechanisms and potential of stem cell secretome-derived exosomes for neuropathic pain (NP) in preclinical and clinical studies.
Pyelolymphatic backflow demonstrated on computed tomography urography in acute ureteric obstruction.
A man in his early 40s presented with acute right flank pain, vomiting and dysuria. Ultrasonography demonstrated an obstructing right upper ureteric calculus with a contralateral renal calculus.
Presumed transdermal superwarfarin toxicity in a pest control worker.
A man in his early 60s presented with dyspnoea and a 2-3 month history of spontaneous mucocutaneous bleeding. Laboratory tests showed unmeasurably elevated INR and activated partial thromboplastin time.
Hepatitis A-associated oxidative haemolysis in a patient with glucose-6-phosphate dehydrogenase deficiency with co-inherited sickle cell trait.
A young male presented with pruritus, nausea, and jaundice following travel to West Africa, lacking hepatitis A vaccination.
Surgical and orthodontic management of class III malocclusion in monozygotic twins using bilateral sagittal split osteotomy.
This case report details the surgical and orthodontic management of class III malocclusion in identical twin sisters in their early 20s, both presenting with mandibular prognathism.
Eosinophilic angiocentric fibrosis in paediatric IgG4-related disease.
A young girl presented with a 1.5-year history of progressive bilateral upper eyelid swelling and proptosis, more pronounced on the right.
Chronic posthypoxic myoclonus: Lance-Adams syndrome.
A man in his 20s developed chronic intentional myoclonus following two cardiac arrests, leading to persistent generalized myoclonic seizures.
Immune-related colitis following head and neck reconstructive surgery in a patient receiving long-term nivolumab.
A man with gastric cancer, receiving long-term nivolumab and prednisolone for immune-related myositis, underwent subtotal glossectomy for advanced tongue cancer. On postoperative day 4, he developed grade 3 diarrhoea.
Comparative efficacy and safety of orally administered PCSK9 inhibitors in patients with Hypercholesterolaemia: a dose-stratified systematic review and network meta-analysis.
This network meta-analysis evaluated the efficacy and safety of orally administered PCSK9 inhibitors in patients with hypercholesterolemia, analyzing five randomized trials with 4,227 participants.
#aware.hiv Europe study: protocol for a stepped-wedge cluster randomised trial of a multimodal hospital-based implementation strategy targeting HIV indicator-condition-guided testing in European hospitals.
The #aware.hiv Europe study is a stepped-wedge cluster randomised trial conducted in 30 hospitals across ten European countries, aiming to improve HIV testing rates among patients with HIV indicator conditions.
Hernia, mesh, microbes, and phage promise: Mapping 35 years of evidence through a systematic review.
This systematic review examined published evidence on microbiology and outcomes of hernia mesh infections, including studies from 1990–2025. Of 584 studies meeting inclusion criteria, 32 contributed to meta-analysis.
Outcomes after middle meningeal artery embolization using coils alone for chronic subdural hematoma: A systematic review and single-arm meta-analysis.
This systematic review and single-arm meta-analysis evaluated the outcomes of coil-only middle meningeal artery embolization (MMAE) for chronic subdural hematoma (cSDH) in 397 patients across 10 studies.
Randomised controlled trial of fluoxetine versus naltrexone in compulsive sexual behaviour disorder.
This randomized controlled trial compared the efficacy and tolerability of fluoxetine and naltrexone in 80 participants with compulsive sexual behaviour disorder (CSBD).
Interactions between vaginal, periurethral and urinary microbiota in genitourinary syndrome of menopause and the effects of local estrogen therapy.
This prospective study characterized vaginal, periurethral, and bladder microbiota in postmenopausal women grouped by atrophy and symptom status, and assessed changes after 12 weeks of vaginal estriol.
Leveraging Longitudinal DBS Recordings to Probe Pharmacological Mechanisms: Investigating the Role of Orexin Antagonists on Extended Amygdala Activity.
A patient with severe, treatment-refractory obsessive-compulsive disorder and comorbid insomnia had beta activity recorded longitudinally from the bed nucleus of the stria terminalis (BNST) using implanted deep brain…
Effectiveness of Immersive and Embodied Enhancement via "Virtual Reality" on the Sustainability of Hand Hygiene Compliance:Protocol for a Randomized Controlled Trial of a School-Based Training Program.
This protocol describes a three-arm randomized controlled trial evaluating customized virtual reality (VR) handwashing education among secondary school students in Hong Kong.
Duplicated spermatic cord encountered during inguinal hernia repair.
A male patient in his seventies presented for elective open right inguinal hernia repair. During the procedure, complete duplication of the spermatic cord was identified, with two distinct structures each containing a…
Adamantinoma-like Ewing sarcoma of the bladder.
A patient presented with a bladder tumor initially diagnosed as urothelial carcinoma following transurethral resection. After receiving neoadjuvant chemotherapy with methotrexate, vinblastine, doxorubicin, and…
Minimally Invasive Versus Sternotomy in Redo Mitral Valve Surgery: Short- and Long-Term Outcomes with Meta-Regression and Time-to-Event Analysis.
This meta-analysis compared minimally invasive mitral valve surgery (MI-MVS) with sternotomy for redo surgery in adults. It included 15 studies and 3457 patients, pooling perioperative outcomes and reconstructing…
Smartphone Measurement Application for Percutaneous Vertebroplasty in Osteoporotic Vertebral Compression Fractures: A Randomized Trial.
This single-center randomized controlled trial compared a LiDAR-enabled smartphone measurement application with conventional anatomical localization and C-arm verification in 43 patients with acute thoracolumbar…
A phase III randomized study: Immunogenicity and safety of a quadrivalent meningococcal conjugate vaccine in healthy adults, adolescents, and children in India and healthy adolescents and children in South Africa.
This Phase III randomized controlled trial assessed the immunogenicity and safety of a single dose of MenACYW-TT in healthy adults, adolescents, and children in India and in adolescents and children in South Africa.
Objective, long-term mobility data in patients with chronic pain after lumbar spine surgery treated with spinal cord stimulation-a prospective, multicenter trial.
This multicenter clinical trial evaluated the long-term effects of spinal cord stimulation (SCS) on mobility in 50 patients with chronic pain following lumbar spine surgery.
Impact of opioid-free general anesthesia with locoregional blocks during breast cancer surgery on systemic inflammatory response: results from a randomized controlled trial.
This randomized controlled trial evaluated the effects of opioid-free general anesthesia with locoregional blocks (OfGA) versus traditional opioid-based general anesthesia (GA) on postoperative inflammation in breast…
Cardiac arrest revealing an occult interventricular septal hydatid cyst in a child.
An 11-year-old girl experienced sudden cardiac arrest during a biopsy of a dorsal hydatid cyst. After resuscitation, echocardiography revealed a 5.3 × 4.6 cm cyst in the interventricular septum, with CT showing liver…
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