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2000 articles
October 202624
TRANSFORM-1 phase 3 study: efficacy and safety of navitoclax plus ruxolitinib in patients with untreated myelofibrosis.
TRANSFORM-1 was a multicentre, randomised phase 3 trial comparing navitoclax plus ruxolitinib with placebo plus ruxolitinib in Janus kinase inhibitor-naïve adults with intermediate-2 or high-risk myelofibrosis.
Short-term Rhodiola rosea supplementation improves premenstrual symptoms, reaction time, and perceived exertion in female taekwondo athletes: a randomised double-blind placebo-controlled trial.
This randomised, double-blind, placebo-controlled trial tested 10 days of Rhodiola rosea (RR) supplementation during the estimated symptomatic premenstrual phase in 24 female taekwondo athletes with moderate-to-severe…
Robotic-assisted conversion of unicompartmental to total knee arthroplasty: a systematic review.
This PRISMA-guided systematic review assessed robotic-assisted conversion of unicompartmental knee arthroplasty (UKA) to total knee arthroplasty (TKA).
Uniportal versus Multiportal Video-Assisted Thoracoscopic Surgery for Minimally Invasive Esophagectomy in Esophageal Cancer: A GRADE-Assessed Systematic Review and Meta-Analysis.
This GRADE-assessed systematic review and meta-analysis compared uniportal (uVATS) with multiportal video-assisted thoracoscopic surgery (mVATS) for minimally invasive esophagectomy in adults with esophageal cancer.
Umbrella review of low-level light therapy: evidence across clinical conditions.
This umbrella review synthesized systematic reviews and meta-analyses of low-level light therapy (LLLT) in humans across clinical conditions. It included 100 reviews, covering 790 unique primary studies.
Modulation of the gut microbiome and resistome by antibiotic use, but not by subsequent 2'-fucosyllactose intake, in adults with overweight or obesity.
This randomized, double-blind, placebo-controlled intervention examined gut microbiome and resistome changes in 18 adults with overweight or obesity after seven days of vancomycin, followed by eight weeks of…
Ponatinib-Blinatumomab or Imatinib-Chemotherapy for Adult Ph-Positive ALL.
This multicenter, phase 3 randomized trial compared frontline ponatinib plus blinatumomab with imatinib plus chemotherapy in adults with Philadelphia-positive acute lymphoblastic leukemia.
Effect of Previsit AI-Generated Document Summaries on Consultation Time and Patient-Physician Communication - The AI-INFOCARE Randomized Controlled Trial.
This single-center randomized controlled trial evaluated whether a quality-checked, AI-generated lay summary of medical findings before outpatient neurosurgical consultations affected communication and consultation…
Body weight following a multidomain lifestyle intervention in older adults at risk of dementia - A post-hoc analysis of the AgeWell.de-trial.
This post-hoc analysis of the cluster-randomized AgeWell.de trial examined body weight in 678 adults aged 60–77 years with overweight or obesity and at risk for dementia.
Optimization of Anticoagulation Strategy During Cardiopulmonary Bypass in Neonates with Congenital Heart Disease: A Randomized Controlled Trial.
Neonatal hemostatic immaturity complicates anticoagulation during cardiopulmonary bypass (CPB). Current practice largely follows the strategy of 400 U/kg from adult protocols, as neonatal-specific guidelines and…
Predicting neurodevelopmental delay among two-year-old infants in Northern Uganda.
This study developed and evaluated a risk-prediction model for neurodevelopmental delay among two-year-old children in Northern Uganda.
Symptom improvement with dosing above 9 g of low-sodium oxybate: effectiveness and safety in participants with narcolepsy in the DUET study.
This prospective, multicohort, open-label study evaluated effectiveness and safety of low-sodium oxybate (LXB) doses above 9 g/night in participants with narcolepsy type 1 or 2 who were already taking 9 g/night.
Giant Cystic Lymphangioma of the Transverse Mesocolon in a 7-Year-Old Child: A Case Report.
A 7-year-old girl presented with several weeks of vomiting, abdominal pain and progressive distension. Examination found a large abdominal mass; laboratory results were unremarkable.
Brigimadlin versus Doxorubicin in Advanced Dedifferentiated Liposarcoma: Efficacy, Safety, and Translational Data from Brightline-1, a Randomized Phase II/III Trial.
Brightline-1 was a randomized phase II/III trial comparing first-line brigimadlin with doxorubicin in patients with MDM2-amplified, locally advanced or metastatic dedifferentiated liposarcoma.
3D-printed reduction guide with hinge and window. Design for conservative veneer preparations.
A 36-year-old woman sought improvement of her smile. Existing ceramic veneers from the maxillary right to left canine showed staining and crack lines, with mild gingival recession around the restored teeth.
Psychoeducational interventions for children and adolescents with potentially traumatic experiences: a systematic review.
This systematic review examined stand-alone psychoeducational interventions for children and adolescents exposed to potentially traumatic experiences, including interventions delivered directly or through caregivers.
A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02.
BilT-02 was a multicenter phase II trial of rucaparib plus nivolumab as maintenance therapy for patients with advanced biliary tract cancer whose disease had not progressed after 4 to 6 months of first-line…
Multimodal assessment of exceptional responders refines subtyping-directed precision treatment in HR+/HER2- breast cancer.
This clinical-trial analysis examined whether multimodal tumour and clinical features could clarify exceptional responses to subtype-directed treatment in locally advanced HR+/HER2− breast cancer.
Safety and immunogenicity of a first-generation modified vaccinia virus Ankara-vectored SARS-CoV-2 vaccine candidate with mRNA-based booster vaccination: A phase 1 trial.
This phase 1 trial assessed safety and immune responses to the MVA-vectored SARS-CoV-2 vaccine MVA-SARS-2-S in 30 healthy, SARS-CoV-2-naive adults given two doses 28 days apart, with six-month follow-up.
The effect of three- and six-session prenatal haptonomy on pregnancy-related anxiety, distress, and psychological well-being: A randomized controlled trial.
This randomized controlled trial assigned 102 pregnant women to three-session prenatal haptonomy, six-session haptonomy, or routine antenatal care.
Efficacy and Safety of Enlicitide in Hypercholesterolemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and random-effects meta-analysis assessed efficacy and safety of oral enlicitide in adults with hypercholesterolemia.
Safety, Tolerability and Antiviral Activity of GST-HG131 in Chronic Hepatitis B: A Randomized, Double-Blind Phase IIa Study.
This randomized, double-blind, placebo-controlled Phase IIa trial assessed oral GST-HG131 in 45 adults with chronic hepatitis B receiving nucleos(t)ide analogue monotherapy.
Cortisol and cognition in psychotic disorders: A systematic review and multi-level meta-analysis.
This systematic review and three-level meta-analysis examined associations between cortisol and cognition in people with psychotic disorders.
Prevalence of urinary incontinence among women in Turkey: A systematic review and meta-analysis.
This systematic review and meta-analysis estimated urinary incontinence (UI) prevalence among women in Türkiye. It included 45 studies published between 2005 and 2025, with 41,038 participants.
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