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2000 articles

October 202624

Case ReportOphthalmology

Anterior Stromal Melt Following Implantation of a Large Size Corneal Allogenic Intrastromal Ring Segment (CAIRS).

To report delayed anterior stromal melt following corneal allogenic intrastromal ring segment (CAIRS) implantation in a patient without known systemic or ocular risk factors.

J Refract SurgOct 1, 2026Read case
Clinical ResearchRheumatology

First-line biologic and targeted synthetic DMARDs versus methotrexate in early rheumatoid arthritis: a meta-analysis of remission outcomes.

This systematic review and meta-analysis of randomized trials compared initial biologic and targeted synthetic DMARDs (b/tsDMARDs), alone or with methotrexate, against methotrexate in methotrexate-naïve adults with…

Rheumatology (Oxford)Oct 1, 2026Read summary
Case ReportHematology

Retrospective RNA Sequencing Reclassifies a Historical t(5;12) Eosinophilic Neoplasm From Presumed PDGFRB Rearrangement to ETV6::ACSL6.

A woman with a chronic eosinophilic myeloid neoplasm had a t(5;12) that raised suspicion of PDGFRB involvement, but contemporary testing did not identify a rearrangement and empiric imatinib produced no meaningful…

Genes Chromosomes CancerOct 1, 2026Read case
Clinical ResearchNeurology

Longitudinal clinical outcomes after amyloid clearance in aducanumab phase 3 studies.

This exploratory analysis pooled participants from the randomized phase 3 ENGAGE and EMERGE aducanumab trials who entered a long-term extension or later redosing study.

Alzheimers DementOct 1, 2026Read summary
Clinical ResearchGastroenterology

Effect of a Computer-Aided Device on Endoscopists' Biopsy Practice for Gastric Neoplasms: A Secondary Analysis of a Randomized Controlled Trial.

This secondary analysis of a randomized controlled trial compared AI-assisted with standard gastric screening, examining biopsy practice for documented lesions.

Dig EndoscOct 1, 2026Read summary
Clinical ResearchOncology (Medical)

Digital health interventions for psychological and cognitive care in cancer patients and caregivers: A RE-AIM-based systematic review.

This PRISMA-guided systematic review assessed the internal and external validity of digital interventions for psychological and cognitive concerns among people with cancer, caregivers, and family members, using the…

Appl Psychol Health Well BeingOct 1, 2026Read summary
Clinical ResearchCardiology

National and Subnational Trends in Ischemic Heart Disease Burden in Iran, 1990-2023: A Systematic Review.

This systematic review synthesized national and subnational evidence on ischemic heart disease (IHD) in Iran from 1990 to 2023, including model-based estimates and empirical studies.

Clin CardiolOct 1, 2026Read summary
Clinical ResearchGeneral Surgery

The Acceptability and Experiences of Participating in a Preoperative Intentional Weight-Loss Programme From Diagnosis to Surgery for Colorectal Cancer.

This qualitative study, embedded in the CARE randomised controlled trial, explored how patients with colorectal cancer experienced an intensive, dietitian-supported weight-loss programme between diagnosis and surgery.

Health ExpectOct 1, 2026Read summary
Clinical ResearchGeriatrics

Prevalence and Predictors of Depressive Symptom Trajectories in Older Adults: A Systematic Review.

This systematic review examined longitudinal patterns of depressive symptoms and their predictors among adults aged 60 years or older.

Brain BehavOct 1, 2026Read summary
Case ReportHematology

Spontaneous splenic rupture in a patient with congenital factor XIII deficiency: A case report and literature review.

A 32-year-old man with congenital factor XIII deficiency presented with sudden abdominal pain and hypovolemic shock. Contrast-enhanced abdominal CT showed a large perisplenic hematoma, and surgery confirmed splenic…

Ulus Travma Acil Cerrahi DergOct 1, 2026Read case
Clinical ResearchHematology

Phase 1 dose escalation and expansion trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein SL-172154 (SIRPα-Fc-CD40L) in patients with higher-risk myelodysplastic syndrome or acute myeloid leukemia.

This Phase I clinical trial evaluated the safety and efficacy of the bispecific CD47 inhibitor SL-172154 combined with azacitidine (AZA) in patients with higher-risk myelodysplastic syndrome (HR-MDS) or acute myeloid…

CancerOct 1, 2026Read summary
Case ReportMedical Genetics

Variants in CEP135 Cause Congenital Microcephaly and Primary Ciliary Dyskinesia.

Three children from two families presented with congenital microcephaly and chronic respiratory issues consistent with primary ciliary dyskinesia (PCD). Diagnostic testing revealed autosomal recessive variants in CEP135.

Pediatr PulmonolOct 1, 2026Read case
Case ReportOrthopedic Surgery

Trauma-related simultaneous asymmetric bilateral hip dislocation: A case report.

A 27-year-old man sustained simultaneous dislocations of both hips after high-energy trauma: the left hip was anteriorly dislocated and the right posteriorly.

Ulus Travma Acil Cerrahi DergOct 1, 2026Read case
Clinical ResearchNeurology

TMS-Derived Neurophysiological Measures of Corticospinal Excitability, Intracortical Excitability, and Interhemispheric Interactions Associated With Post-Stroke Motor Recovery: A Systematic Review.

This systematic review evaluated the relationship between TMS-derived neurophysiological measures and motor recovery in adults post-stroke, synthesizing data from 16 randomized controlled trials.

Eur J NeurosciOct 1, 2026Read summary
Clinical ResearchInfectious Diseases

Development of HOPES Intervention for a Randomized Controlled Trial to Reduce the Perceived Stigma Among Women Living With HIV/AIDS in China.

This study developed and pilot-tested HOPES, a culturally grounded WeChat program intended to reduce HIV-related stigma among Chinese women living with HIV/AIDS.

AIDS Educ PrevOct 1, 2026Read summary
Clinical ResearchNeurology

Health Economic & Implementation Determinants of Prehospital Stroke Triage Tools: A Systematic Review.

This systematic review evaluated health economic outcomes and implementation determinants of prehospital triage tools for suspected ischaemic stroke patients.

J Eval Clin PractOct 1, 2026Read summary
Clinical ResearchPediatrics

Sensory processing and executive functioning interaction in neurodevelopmental disorders and at-risk conditions: A systematic review and meta-analysis.

This systematic review and meta-analysis examined associations between sensory processing (SP) and executive functioning (EF) in children and adolescents aged 0–18 with neurodevelopmental disorders or at-risk…

Neurosci Biobehav RevOct 1, 2026Read summary
Clinical ResearchPhysical Medicine & Rehabilitation

Dose Considerations and Generalization Following Script Training for Poststroke Aphasia: A Randomized Factorial Clinical Trial.

This single-site, single-blind, 2 × 2 factorial randomized controlled trial examined how script length and session frequency affect treatment outcomes in 85 people with chronic poststroke aphasia.

J Speech Lang Hear ResOct 1, 2026Read summary
Clinical ResearchPsychiatryOpen access

Psychoeducation for Youth at Clinical High-Risk of Psychosis.

This clinical trial evaluated the effects of psychoeducation on 54 youth at clinical high risk of psychosis. After 2-6 months, significant improvements were noted in attenuated psychotic symptoms, depression, and…

Early Interv PsychiatryOct 1, 2026Read summary
Clinical ResearchPathology (Anatomic & Clinical)

Oral peri-implant tissue as a neoplastic bed: a systematic review of clinicopathology, pathogenesis, and survival outcomes.

This systematic review assessed the clinicopathology, associated factors, and survival outcomes of histologically confirmed neoplasms adjacent to dental implants.

J Craniomaxillofac SurgOct 1, 2026Read summary
Case ReportPathology (Anatomic & Clinical)

Calcitonin-negative 'MTC-like' thyroid paraganglioma revealing an SDHD-related hereditary paraganglioma syndrome: functional confirmation of a non-canonical splice-site variant.

A 36-year-old woman presented with a 20-mm thyroid nodule classified as EU-TIRADS 4 and Bethesda III, with normal serum calcitonin levels.

Eur Thyroid JOct 1, 2026Read case
Clinical ResearchPsychiatry

Negative affect influences the computations underlying food choice in bulimia nervosa.

This randomized controlled trial examined how negative affect influences food choice dynamics in 25 women with bulimia nervosa (BN) and 21 healthy controls.

ElifeOct 1, 2026Read summary
Case ReportNeurosurgery

The Urgent Surgical Outcome of Intracranial Subdural Empyema: A Case Presentation.

A patient presented unconscious due to intracranial subdural empyema, a severe brain infection. Urgent surgical intervention was performed, leading to a rapid recovery postoperatively.

Mymensingh Med JOct 1, 2026Read case
Case ReportInfectious Diseases

Human Infection with Japanese Encephalitis Virus Genotype V, China, 2025.

A human case of Japanese encephalitis virus genotype V (JEV GV) was confirmed in China through serological testing, sequencing, and quantitative reverse transcription PCR.

Emerg Infect DisOct 1, 2026Read case

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