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2000 articles

October 202624

Clinical ResearchPlastic Surgery

Multiple-Staged Versus Single-Stage Surgical Excision for the Reconstruction of Congenital Melanocytic Nevi: A Meta-Analysis of Efficacy and Safety.

This meta-analysis compared multiple-staged with single-stage excision and reconstruction for congenital melanocytic nevi (CMN). It pooled seven retrospective cohort or clinical controlled studies involving 578 patients.

Ann Ital ChirOct 14, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Immune biomarkers of response and resistance to ipilimumab and nivolumab in metastatic castration-resistant prostate cancer.

The multicenter phase II AMADEUS prostate expansion cohort evaluated escalating ipilimumab doses with nivolumab in 32 patients with metastatic castration-resistant prostate cancer, assessing disease control, tumoral CD8…

Sci AdvOct 14, 2026Read summary
Clinical ResearchOncology (Medical)

Impact of body composition on clinical outcomes in patients with hepatocellular carcinoma: A systematic review and meta-analysis.

This systematic review and meta-analysis examined associations between body composition and outcomes in patients with hepatocellular carcinoma (HCC), across curative, locoregional, systemic, and mixed treatment…

Hepatol CommunOct 14, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Anxiety in patients with cancer and emergency department use: a systematic review.

This systematic review examined whether anxiety is associated with subsequent emergency department (ED) use among adults with cancer.

Support Care CancerOct 14, 2026Read summary
Clinical ResearchGastroenterology

Patient-reported and caregiver-reported outcomes in refractory ascites secondary to cirrhosis: A systematic review and meta-analysis.

This systematic review and meta-analysis examined patient- and caregiver-reported outcomes in refractory ascites (RA) secondary to advanced chronic liver disease.

Hepatol CommunOct 14, 2026Read summary
Case ReportMedical Genetics

Aberrant splicing caused by a homozygous AK2 c.498 + 1G > A variant in a patient with reticular dysgenesis and concurrent B-cell acute lymphoblastic leukemia.

A boy with reticular dysgenesis (RD), a severe immunodeficiency associated with biallelic AK2 loss of function, was also diagnosed with B-cell acute lymphoblastic leukemia (B-ALL).

GeneOct 14, 2026Read case
Case ReportNeurology

A 35-Year-Old Woman With Multiple Sclerosis and a New Atypical Thalamic Lesion: A Case Report From the National Multiple Sclerosis Society Case Conference Proceedings.

A 35-year-old woman with multiple sclerosis developed an enlarging thalamic lesion. Although new or enlarging lesions in MS can indicate disease activity, the lesion was ultimately diagnosed as a diffuse midline glioma…

Neurol Neuroimmunol NeuroinflammOct 14, 2026Read case
Clinical ResearchDermatology

The Use of Cannabidiol in Cutaneous Wound Healing: A Systematic Review.

This qualitative systematic review assessed cannabidiol (CBD) for cutaneous wound healing, including in vivo studies and clinical trials identified through searches of seven databases. Six studies were included.

FASEB JOct 14, 2026Read summary
Clinical ResearchGastroenterology

Clinical, safety, and patient-reported outcomes associated with second-line and later therapies in primary biliary cholangitis: A systematic review.

This systematic literature review examined clinical, safety, and patient-reported outcomes for second-line and later therapies in people with primary biliary cholangitis who had an inadequate response or intolerance to…

Hepatol CommunOct 14, 2026Read summary
Clinical ResearchPreventive Medicine / Public Health

A Single Exercise Session Elicits a Transient Kynurenine Metabolic Signature in Health and Disease: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis examined acute changes in circulating tryptophan (TRP) and kynurenine-pathway metabolites after a single exercise session.

FASEB JOct 14, 2026Read summary
Clinical ResearchPsychiatry

An Internet-Based Cognitive-Behavioral Program, With Telephone Support, Improves Pain, Disability and Emotional Well-Being in Adults With Chronic Pain: Randomized Controlled Trial of the Pain Course With 2-Year Follow-Up.

This randomised controlled trial evaluated an internet-delivered, cognitive-behavioral Pain Course with clinician support in adults with chronic pain living in Ireland.

Clin J PainOct 14, 2026Read summary
Clinical ResearchPhysical Medicine & RehabilitationOpen access

Immediate effects of spinal manipulation, exercise therapy, and open-label placebo on lifting performance and pain in individuals with chronic non-specific back pain: a motion laboratory-based crossover randomized controlled trial.

This motion-laboratory crossover randomised controlled trial examined immediate effects of spinal manipulation (SMT), exercise therapy (ET), and open-label placebo (OLP) on lifting and pain in 50 individuals with…

Chiropr Man TherapOct 14, 2026Read summary
Clinical ResearchDermatologyOpen access

Targeting an IL-17/IL-36 pathogenic hub in hidradenitis suppurativa with a bispecific antibody.

This phase I/II proof-of-concept clinical trial evaluated HB0043, a bispecific antibody targeting IL-17A and IL-36R, in patients with severe, tunnel-dominant Hurley Stage III hidradenitis suppurativa.

Signal Transduct Target TherOct 14, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Camrelizumab plus chemotherapy as induction therapy followed by concurrent chemoradiotherapy and camrelizumab consolidation in limited-stage small cell lung cancer: a randomized phase II trial.

This randomized phase II trial compared a camrelizumab-based induction and consolidation strategy with induction chemotherapy followed by concurrent chemoradiotherapy (CRT) alone in previously untreated patients with…

Signal Transduct Target TherOct 14, 2026Read summary
Case ReportCardiology

Bee Sting-Associated Kounis Syndrome Presenting as Myocardial Infarction: A Case Report and Systematic Review with Age-Based Analysis.

A 44-year-old man presented with myocardial infarction after a probable bee sting-associated allergic reaction and was considered to have Kounis syndrome, an acute coronary syndrome linked to hypersensitivity.

Turk Kardiyol Dern ArsOct 13, 2026Read case
Clinical ResearchObstetrics & Gynecology

Clinical, economic, and health-related quality of life impact of intrapartum group B Streptococcus (GBS) tests for prevention of neonatal GBS infection: a systematic literature review.

This systematic literature review assessed the clinical performance, economic impact, and health-related quality of life associated with intrapartum group B Streptococcus (GBS) screening.

J Matern Fetal Neonatal MedOct 13, 2026Read summary
Clinical ResearchCardiologyOpen access

Fibro-Inflammatory Signaling, Fibrosis, and Microvascular Ischemia as Convergent Translational Substrates of Sudden Cardiac Death in Hypertrophic Cardiomyopathy: A Systematic Review.

This systematic translational review examined whether fibro-inflammatory signaling, fibrosis, and microvascular ischemia converge as substrates for ventricular arrhythmia and sudden cardiac death in hypertrophic…

J Cardiovasc Transl ResOct 13, 2026Read summary
Case ReportNeurosurgery

Stroke thrombectomy of a mural thrombus in a severe dolichoectatic basilar artery with double parallel large stent retrievers and Sofia 88.

An older adult presented with severe acute ischemic stroke from a mural thrombus on the posterior wall of the mid-basilar artery.

J Neurointerv SurgOct 13, 2026Read case
Case ReportNeurologyOpen access

Clinicopathologic Evaluation of Amyloid Clearance in Alzheimer Disease.

A man in his 50s with mild cognitive impairment and the Alzheimer disease risk-associated p.R47H TREM2 variant received 30 doses of aducanumab (cumulative dose 280 mg/kg) over 4.5 years in a clinical trial.

JAMAOct 13, 2026Read case
Clinical ResearchOtolaryngology (ENT)

Adenotonsillectomy for children with mild sleep-disordered breathing: who benefits?

This secondary analysis of a 12-month, multicentre randomised trial examined children aged 3.0–12.9 years with mild sleep-disordered breathing, comparing early adenotonsillectomy (eAT) with watchful waiting and…

SleepOct 13, 2026Read summary
Clinical ResearchDermatology

Clinical translation of polymeric microneedles for bioactive nanovesicle delivery in hypertrophic scar remodeling.

This prospective, single-center, open-label, single-arm study evaluated a 12-week protocol combining microplasma radiofrequency, poly(L-lactic acid) microneedles, and topical milk-derived bioactive nanovesicles in 26…

Biomater SciOct 13, 2026Read summary
Clinical ResearchPediatricsOpen access

Daily Zinc Supplementation for Infection Prevention in Children With Sickle Cell Anemia: The ZIPS-2 Randomized Clinical Trial.

The ZIPS-2 randomized, double-blind, placebo-controlled trial evaluated daily zinc for infection prevention in children aged 1 to 4.99 years with sickle cell anemia in Uganda.

JAMAOct 13, 2026Read summary
Clinical ResearchCardiologyOpen access

Cold and Room-Temperature Platelets in Cardiac Surgery: The CHIPS Randomized Clinical Trial.

The phase 3, multicenter, randomized CHIPS trial compared cold-stored platelets (CSPs; up to 21 days) with room-temperature platelets (RTPs; up to 7 days) in pediatric and adult patients receiving platelet transfusions…

JAMAOct 13, 2026Read summary
Clinical ResearchGastroenterology

Network Meta-Analysis: Treatments for Acute Alcohol-Associated Hepatitis.

This systematic review and network meta-analysis compared treatments for alcohol-associated hepatitis (AH) using 90-day survival as the primary outcome.

Liver IntOct 13, 2026Read summary

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