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2000 articles
October 202624
Berberine improves diabetic foot ulcer healing after tibial transverse osteotomy by inhibiting the PDGF-B/PDGFRβ signaling pathway .
This prospective, single-centre, randomized, placebo-controlled trial evaluated local berberine injections added to tibial transverse osteotomy (TTO) in patients with Wagner grade 2–4 diabetic foot ulcers.
Effectiveness of Exercise Snacks in Mitigating Adolescent Problematic Smartphone Use: A Four-Wave Cluster Randomized Controlled Trial.
This four-wave cluster randomized controlled trial tested whether brief, vigorous activity breaks could reduce problematic smartphone use among 386 adolescents in 12 secondary-school classes.
Effectiveness of Implantable Cardioverter-Defibrillator Therapy for Primary Prevention in Patients with Nonischemic Heart Failure with Reduced Ejection Fraction.
This rapid systematic review and meta-analysis assessed primary-prevention implantable cardioverter-defibrillator (ICD) therapy in patients with nonischemic heart failure with reduced ejection fraction, drawing on 18…
Consequences of opioid exposure in disease-free cancer survivors: A systematic literature review.
This systematic literature review examined the consequences of persistent opioid exposure after curative-intent treatment in disease-free cancer survivors.
Crisis Interventions for Children and Adolescents with Depression and Suicidality: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined crisis services for children and adolescents experiencing acute mental health crises, including severe depression, suicidal ideation, self-harm, and suicidal behaviour.
Lithium in the Prevention of Postpartum Recurrence of Mood Disorders: A Systematic Review and Meta-Analysis.
This systematic review and random-effects meta-analysis assessed postpartum mood-disorder recurrence among women with bipolar I or II disorder, comparing those who received prophylactic lithium with those who did not.
Impact of age and frailty on the effect of a multimodal individualized long-term intervention after stroke: the last-long trial.
This single-blinded, multicentre randomized controlled trial examined whether age or frailty modified response to a stroke coordinator-led, individualized community intervention.
A randomized study comparing plant sterol- and soluble fiber-enriched soymilk with plain soymilk in adults with elevated LDL cholesterol.
This randomized controlled trial compared plant sterol- and soluble fiber-enriched soymilk with plain soymilk in 242 adults with hypercholesterolemia, untreated or on stable lipid-lowering therapy.
Extensive Arterial Thrombosis Complicating Acute Pancreatitis: A Case Report and Literature Review.
A 61-year-old man with chronic pancreatitis developed acute interstitial edematous pancreatitis. Four weeks after presentation, persistent dyspepsia prompted contrast-enhanced CT, which showed pancreatic pseudocysts and…
A novel PGAP1 splice-site variant expanding the clinical and molecular spectrum of GPI-anchor disorders.
A patient with neurodevelopmental impairment was found to carry a novel homozygous PGAP1 splice-site variant, NM_024989.4.1173 + 1G > A.
Fishbone-Induced Gastrointestinal Perforation: A 21-Case Series from Vietnam.
This retrospective series included 21 patients treated for fishbone-induced gastrointestinal perforation at a tertiary hospital in southern Vietnam.
Tricuspid Chordae Tendineae Rupture Detected After Repair of a Delayed Traumatic Left Ventricular Aneurysm: A Case Report.
After a fall from a height, a patient presented 54 days later with rupture of a posterior left ventricular aneurysm. Venoarterial extracorporeal membrane oxygenation provided circulatory support before surgical aneurysm…
Prognostic associations between patient-reported outcomes and progression-free and overall survival in advanced gastric or gastroesophageal junction adenocarcinoma with PD-L1 TAP score ≥ 5%: results from the RATIONALE-305 trial.
This analysis of the randomised RATIONALE-305 trial examined whether longitudinal patient-reported outcomes (PROs) were associated with progression-free survival (PFS) and overall survival (OS) in patients with advanced…
Neoadjuvant short-course radiotherapy followed by camrelizumab and chemotherapy versus standard of care for locally advanced rectal cancer (UNION): a prespecified interim analysis of a multicentre, open-label, randomised, phase 3 trial.
UNION was a multicentre, open-label, randomised phase 3 trial at nine hospitals in China comparing neoadjuvant short-course radiotherapy followed by camrelizumab plus CAPOX with long-course chemoradiotherapy followed by…
Measurement Properties of Hand-Held Dynamometry for Ankle Strength Assessment: A COSMIN-Based Systematic Review and Meta-Analysis.
This COSMIN-based systematic review and meta-analysis assessed handheld dynamometry (HHD) for measuring isometric ankle muscle strength in healthy individuals.
Poland Syndrome with transverse upper limb deficiency: beyond the vascular disruption hypothesis.
A neonate presented with right-sided pectoral deficiency and an ipsilateral transverse upper limb deficiency at the carpal level.
Reduced-dose alternate-day oral iron supplementation in women with iron deficiency: a randomized controlled trial.
This 42-day, randomized, parallel-group active-controlled trial compared two oral iron regimens in 66 women aged 18–50 years with iron deficiency (serum ferritin < 30 ng/mL).
Disseminated Trimethoprim/Sulfamethoxazole-Resistant Nocardiosis in Renal Transplant Recipient, India.
A renal transplant recipient in India taking trimethoprim/sulfamethoxazole prophylaxis presented with fever, hemoptysis, and neurologic deficits.
A 66-Year Old Female with Belly Dancer's Syndrome: A Case Report from a Low-Resource Setting.
A 66-year-old woman with well-controlled hypertension had a 15-year history of intermittent jerky abdominal-wall movements, preceded by a burning epigastric sensation and associated with abdominal pain, dyspnoea and…
Dirofilaria asiatica Infection and Asymptomatic Microfilaremia, Sri Lanka, 2025.
During night blood surveillance for lymphatic filariasis in Sri Lanka in 2025, two people were found to have asymptomatic Dirofilaria microfilaremia.
Persistent Microfilaremia Caused by Dirofilaria asiatica Infection in 2-Year-Old Child, Sri Lanka, 2024.
A 2-year-old child in Sri Lanka was found to have a patent infection with Dirofilaria asiatica, a canine filarioid implicated in zoonotic human infection.
Efficacy and safety of mitapivat in patients with sickle cell disease (RISE UP): a phase 3, double-blind, global, randomised, placebo-controlled trial.
RISE UP was a phase 3, double-blind, global, randomised, placebo-controlled trial conducted at 69 sites in 15 countries. It evaluated twice-daily mitapivat in patients older than 16 years with sickle cell disease…
Combination therapy of carbon dioxide laser with topical halometason cream and 308 nm excimer laser for the treatment of vitiligo: an optimized combined treatment protocol.
This randomized controlled trial evaluated fractional CO₂ laser plus topical halometasone cream and 308-nm excimer lamp therapy for refractory non-segmental vitiligo, compared with excimer therapy, a topical calcineurin…
Fatal Rickettsia parkeri Rickettsiosis in Immunocompromised Pediatric Patient, Georgia, USA, 2025.
A 3-year-old boy in Georgia, USA, receiving chemotherapy for B-cell acute lymphoblastic leukemia was hospitalized with febrile neutropenia.
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