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2000 articles
October 202624
Treatment of Progressive Multifocal Leukoencephalopathy With Third-Party Allogeneic BK Virus T Cells.
This single-center phase 2 study evaluated third-party, partially HLA-matched BK virus-specific T cells in 37 patients with progressive multifocal leukoencephalopathy (PML), including 23 with hematologic malignancy.
Effect of intraoral glossopharyngeal nerve block on hemodynamic response to mouth retractor placement in transoral robotic surgery: a randomized clinical trial.
This prospective, single-centre randomized clinical trial assessed whether bilateral intraoral glossopharyngeal nerve block attenuates the blood-pressure response to mouth retractor placement during transoral robotic…
ACUTE BILATERAL RETINAL AND CHOROIDAL DETACHMENT-A CASE REPORT.
A 57-year-old man developed profound bilateral visual loss while hospitalized with sepsis of unknown cause and was referred three weeks later with bilateral retinal detachment.
Breastfeeding and maternal bone health 10 years postpartum: findings from the ROLO longitudinal cohort study.
This longitudinal cohort analysis examined whether breastfeeding behaviours were associated with maternal bone health 10 years after pregnancy.
Post-transplant BRAF/MEK inhibitor maintenance sustains complete remission in BRAF V600E-mutant histiocytic sarcoma.
A patient with refractory BRAF V600E-mutant histiocytic sarcoma achieved complete remission with BRAF/MEK inhibition and then underwent allogeneic stem cell transplantation.
Recurrent Nodular Lymphocyte Predominant Hodgkin Lymphoma with Diagnostic Evolution Over Two Decades.
A 51-year-old man had a nearly 20-year history of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), with multiple relapses and prolonged remissions.
Targeted BRAF /MEK inhibition as a salvage therapy for patients with metastatic melanoma harboring a BRAF L597R mutation: two case reports and review of the literature.
Two patients with metastatic melanoma harboring the BRAF L597R mutation had rapid clinical deterioration and disease progression after dual immune checkpoint inhibition.
Impact of acoramidis on clinical stability in transthyretin amyloid cardiomyopathy: observations from ATTRibute-CM.
This post-hoc analysis of the phase 3, multicentre, randomised ATTRibute-CM trial assessed clinically meaningful changes in NT-proBNP or 6-minute walk distance among participants with transthyretin amyloid…
Rapid-Onset Subacute Combined Degeneration After Short-Term, High-Dose Nitrous Oxide Use.
The title identifies a case of rapid-onset subacute combined degeneration (SCD) after short-term, high-dose recreational nitrous oxide use.
Efficacy and Safety of Short-Course Radiotherapy Alone or Combined With Consolidation Chemotherapy Versus Conventional Long-Course Chemoradiotherapy for Locally Advanced Rectal Cancer: A Meta-Analysis of Randomized Controlled Trials.
This meta-analysis of randomized controlled trials compared short-course radiotherapy (SCRT), with or without consolidation chemotherapy, against long-course chemoradiotherapy (LCCRT) for locally advanced rectal cancer.
Proof-of-Concept Phase 2a Trial of VH4524184: An Emerging Third-Generation Integrase Strand Transfer Inhibitor With an Enhanced Resistance Profile.
This randomized, double-blind, placebo-controlled phase 2a trial assessed short-course oral VH-184 monotherapy in adults with HIV-1 who were antiretroviral-therapy naive and had HIV-1 RNA ≥ 3000 copies/mL.
Germline BRCA-Lynch syndrome MINAS: report of six Argentinian families and a systematic review of the literature.
This report combined six Argentinian families with a systematic review of 40 publications to describe the phenotype of BRCA-Lynch syndrome (BRCA-LS) MINAS. The analysis included 92 patients from 69 families.
Neck-Specific Exercises With Internet Support Versus Standard Neck-Specific Exercise for the Treatment of Chronic Whiplash-Associated Disorders: Cost-Effectiveness Analysis.
This prospective, multicenter randomized controlled trial compared a 3-month internet-supported neck-specific exercise program plus four physiotherapy visits (NSEIT) with clinic-based neck-specific exercise twice weekly…
Impact of Intermittent Preventive Treatment for Malaria in Pregnancy With Sulfadoxine-Pyrimethamine, Dihydroartemisinin-Piperaquine, and Their Combination on Infant Outcomes: A Randomized Controlled Trial.
This double-blind randomized controlled trial compared infant malaria and growth outcomes after maternal intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine (SP), dihydroartemisinin-piperaquine…
FLANGED INTRASCLERAL INTRAOCULAR LENS FIXATION USING 31-G NEEDLES.
A 73-year-old man with right intraocular lens (IOL) subluxation underwent flanged intrascleral IOL fixation using the double-needle technique with a 31-gauge needle.
Ergonomic interventions for treating work-related complaints of the arm, neck or shoulder in adults.
This Cochrane systematic review and meta-analysis assessed ergonomic interventions for work-related arm, neck or shoulder complaints (CANS) in adults.
IDIOPATHIC RETINITIS VASCULITIS ANEURYSMS AND NEURORETINITIS (IRVAN) TREATED WITH ADALIMUMAB: A CASE REPORT.
An adolescent with idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) was initially treated with panretinal photocoagulation and intravitreal ranibizumab in both eyes.
Postoperative Pain Treatment After Pancreatic Surgery: A Systematic Review With Meta-Analyses and Trial Sequential Analyses.
This PROSPERO-registered systematic review and meta-analysis examined postoperative analgesia after total pancreatectomy, pancreaticoduodenectomy, and distal pancreatectomy.
Left anterior laryngeal loop of the common carotid artery in a cluster of bilateral cervicothoracic vascular variants: a case report.
CTA demonstrated a common-origin left common carotid artery (CCA)–brachiocephalic trunk, a high-riding brachiocephalic trunk, and bilateral carotid and external carotid artery variants.
SUBRETINAL LAVAGE DURING DIAGNOSTIC VITRECTOMY: AN ADJUNCTIVE TECHNIQUE FOR CELL SAMPLING IN SUSPECTED VITREORETINAL LYMPHOMA.
In patients with suspected vitreoretinal lymphoma and predominant subretinal involvement, standard vitreous sampling may have limited sensitivity.
Familial Glioma in a Father and Son: Integrated Genomic and Multi-compartment Proteomic Profiling.
A 60-year-old father and his 35-year-old son presented with gliomas. The father’s tumor was glioblastoma, IDH-wildtype, WHO grade 4, with an unmethylated MGMT promoter; the son’s was astrocytoma, IDH-mutant, WHO grade…
Cranial and Spinal Epithelioid Hemangioma: Systematic Review and Illustrative Calvarial Case.
Cranial and neuraxial epithelioid hemangioma (EH) is exceptionally rare and anatomically heterogeneous. We systematically reviewed reported cerebral, cranial osseous, primary non-osseous spinal epidural, and…
A Randomized, Double-Blind, Placebo-Controlled Study of the PD-1 Inhibitor Cetrelimab in Chronic Hepatitis B.
This randomized, double-blind, placebo-controlled study assessed the safety, activity and pharmacokinetics of a single low dose of the PD-1 inhibitor cetrelimab in adults with chronic hepatitis B virologically…
TEN-YEAR FOLLOW-UP OF FLUID FLUCTUATIONS IN A PATIENT WITH OPTIC DISK PIT MACULOPATHY.
A patient with optic disk pit maculopathy had severe subretinal fluid involving the fovea and underwent pars plana vitrectomy. The fluid resolved for 2 years, then subretinal fluid recurred alongside intraretinal fluid.
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