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1566 articles
October 202624
Efficacy and safety of switching to once-daily oral doravirine plus raltegravir in virologically suppressed people with HIV-1: a randomized, open-label, multicentre phase 2 study (DORAL).
DORAL was a multicentre, open-label, randomized phase II trial in virologically suppressed adults with HIV-1 on stable antiretroviral therapy, without prior doravirine exposure or raltegravir resistance.
Smartphone Measurement Application for Percutaneous Vertebroplasty in Osteoporotic Vertebral Compression Fractures: A Randomized Trial.
This single-center randomized controlled trial compared a LiDAR-enabled smartphone measurement application with conventional anatomical localization and C-arm verification in 43 patients with acute thoracolumbar…
Leveraging Longitudinal DBS Recordings to Probe Pharmacological Mechanisms: Investigating the Role of Orexin Antagonists on Extended Amygdala Activity.
A patient with severe, treatment-refractory obsessive-compulsive disorder and comorbid insomnia had beta activity recorded longitudinally from the bed nucleus of the stria terminalis (BNST) using implanted deep brain…
Standardized Acupuncture Plus Modified Xiaoxuming Decoction for Acute Ischemic Stroke: A Randomized Controlled Trial.
This single-center, assessor-blinded randomized controlled trial enrolled adults with imaging-confirmed acute ischemic stroke within 72 hours and compared standard care with or without standardized acupuncture plus…
Effectiveness of Immersive and Embodied Enhancement via "Virtual Reality" on the Sustainability of Hand Hygiene Compliance:Protocol for a Randomized Controlled Trial of a School-Based Training Program.
This protocol describes a three-arm randomized controlled trial evaluating customized virtual reality (VR) handwashing education among secondary school students in Hong Kong.
Physical activity for psychological and physical well-being in menstruating individuals: an integrative review.
This integrative review synthesised qualitative, quantitative, and mixed-methods research on physical activity and psychological or physical well-being across the menstrual cycle.
Febrile neutropenia in adults with diffuse large B-cell lymphoma receiving first-line R-CHOP-based therapy: a systematic review and meta-analysis of observational and trial evidence.
This systematic review and meta-analysis assessed febrile neutropenia (FN) in adults with diffuse large B-cell lymphoma receiving first-line R-CHOP or R-CHOP-like therapy, separating observational cohorts from clinical…
Changes in health literacy following participation in a multidisciplinary primary care intervention for people with chronic pain: a longitudinal cohort study.
This longitudinal cohort study examined changes in health literacy among 43 people with chronic non-cancer pain who completed a personalized, multidisciplinary primary care pain-management intervention.
'Life has become a lot easier'-the acceptability of the treatable traits clinic experience to people with bronchiectasis.
This exploratory qualitative study examined how adults with bronchiectasis experienced a regional Australian outpatient clinic using a treatable-traits approach.
Minimally Invasive Versus Sternotomy in Redo Mitral Valve Surgery: Short- and Long-Term Outcomes with Meta-Regression and Time-to-Event Analysis.
This meta-analysis compared minimally invasive mitral valve surgery (MI-MVS) with sternotomy for redo surgery in adults. It included 15 studies and 3457 patients, pooling perioperative outcomes and reconstructing…
Rupture of Left Ventricular Aneurysm in Infant: Case Report.
A preterm infant hospitalized from birth with necrotizing enterocolitis, later complicated by ascending-colon narrowing requiring surgery, had persistent infections with Staphylococcus haemolyticus and then…
Neuromuscular, Balance, and Gait Factors Associated with Falls and Fall-Related Outcomes in Individuals with COPD: A Systematic Review.
This systematic review examined associations between muscle strength, balance, gait and falls or fall-related outcomes in people with COPD. It included 25 original studies involving 1295 participants.
Severe Euglycemic Diabetic Ketoacidosis After Semaglutide-Associated Poor Intake Despite Empagliflozin Discontinuation: A Case Report.
A 68-year-old woman with long-standing type 2 diabetes developed several weeks of nausea, intermittent vomiting and diarrhea, and minimal oral intake after starting semaglutide.
Brief social contact videos to promote treatment seeking among young adults with depressive symptoms: Intention change, suicidal ideation, and treatment use in a randomized controlled trial.
This randomized controlled trial tested whether brief social contact videos featuring personal recovery stories increased help-seeking and treatment use among 1,545 young adults aged 18–25 years with depressive…
Cannabis use and subsequent onset of manic symptoms and bipolar disorder: A systematic review and meta-analysis.
This registered systematic review and meta-analysis examined longitudinal observational studies of people without prior bipolar disorder, comparing those exposed and unexposed to cannabis.
Exercise to enhance antipsychotic effectiveness and mitigate metabolic harm: systematic review and meta-analysis.
This systematic review and meta-analysis pooled randomised controlled trials of supervised exercise in adults receiving antipsychotic medication for psychotic disorders.
Maternal circulating cytokine and chemokine levels during pregnancy and risk of autism spectrum disorder in offspring: A systematic review and meta-analysis.
This systematic review and meta-analysis examined whether maternal blood cytokine and chemokine levels during pregnancy were associated with autism in offspring, drawing on seven human observational studies.
Hernia, mesh, microbes, and phage promise: Mapping 35 years of evidence through a systematic review.
This systematic review examined published evidence on microbiology and outcomes of hernia mesh infections, including studies from 1990–2025. Of 584 studies meeting inclusion criteria, 32 contributed to meta-analysis.
Bilateral gamma knife radiosurgery in severe essential tremor: a prospective trial.
This phase II prospective trial evaluated the safety and efficacy of staged bilateral Gamma Knife radiosurgery (GKS) of the ventral intermedius thalamic nucleus in 33 patients with severe essential tremor.
World's first case report of live birth following autologous ovarian tissue cryopreservation and transplantation in a patient with colon carcinoma.
A 29-year-old woman with colon cancer underwent ovarian tissue cryopreservation prior to chemotherapy. After developing premature ovarian insufficiency, she received two transplantations of thawed ovarian cortex strips.
Systematic review and meta-analysis: the effectiveness of cognitive behavioral therapy and eye movement desensitization and reprocessing in children and adolescents.
This systematic review and meta-analysis evaluated the effectiveness of cognitive behavioral therapy (CBT) versus eye movement desensitization and reprocessing (EMDR) for treating PTSD in children and adolescents aged…
Navigating the unexpected: management of incidental severe Factor V deficiency in term pregnancy.
A primigravida was found to have severe Factor V deficiency (<1% activity) during routine preoperative evaluation for an elective caesarean section, despite being asymptomatic and having no bleeding history.
Adrenal metastasis from papillary thyroid cancer: staged surgical resection.
A man in his 70s with a history of papillary thyroid carcinoma presented with recurrence in the right cervical lymph nodes and a right adrenal mass measuring 5.7×6.5 cm. A CT-guided biopsy confirmed metastatic disease.
Gastrointestinal manifestations of IgA vasculitis guiding treatment in an adult patient.
A man in his 20s presented with abdominal pain, post-prandial vomiting, a purpuric rash, arthralgia, and hypertension. Urine studies indicated subnephrotic range proteinuria, and colonoscopy revealed ileal ulceration.
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