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1687 articles
October 202624
Fosfomycin as Oral Transition Therapy Versus Continued Intravenous β-Lactams for Complicated Urinary Tract Infections Caused by Extended-Spectrum β-Lactamase-Producing Enterobacterales: A Multicenter, Open-Label, Randomized Controlled Trial.
This multicenter, open-label randomized noninferiority trial compared oral fosfomycin transition therapy with continued intravenous carbapenem or β-lactam/β-lactamase inhibitor therapy in hospitalized adults with…
Multidimensional Poverty and Implementation Reach of Household Contact Tracing for Tuberculosis in South Africa: Analysis of a Randomized Trial.
This analysis of a cluster-randomized trial in South Africa examined whether household multidimensional poverty was associated with the reach of household contact tracing (HHCT) for tuberculosis.
Phase 2a Randomized Placebo-Controlled Human Challenge Trial of the Respiratory Syncytial Virus L-Protein Inhibitor S-337395 for Respiratory Syncytial Virus Infection.
This phase 2a, randomized, double-blind, placebo-controlled, single-centre human challenge trial assessed oral S-337395 in healthy adults aged 18–55 years inoculated with RSV-A Memphis 37b.
Three Months of Weekly Rifapentine and Isoniazid Versus Four Months of Daily Rifampicin for Tuberculosis Infection: A Randomized Controlled Trial.
This multicenter, open-label randomized controlled trial compared treatment completion with weekly isoniazid plus rifapentine for 3 months (3HP) versus daily rifampicin for 4 months (4RIF) among people of any age with…
Immunogenicity and Safety of the Adjuvanted Respiratory Syncytial Virus Prefusion F Protein-Based Vaccine When Co-administered With the Adjuvanted Recombinant Herpes Zoster Subunit Vaccine in Adults ≥ 50 Years of Age.
This phase III, open-label, randomised trial compared co-administration of adjuvanted RSVPreF3 and recombinant zoster vaccine (RZV) with administration one month apart in adults aged ≥50 years.
A Phase 1/2 Dose-Ranging Safety and Immunogenicity Study of mRNA-Based Candidate Pandemic Influenza Vaccines in Healthy Adults.
This randomised phase 1/2 dose-ranging study evaluated the safety, reactogenicity, and immunogenicity of mRNA-1018 pandemic influenza vaccine candidates in healthy adults.
Immunogenicity and Safety of Co-administration of Adjuvanted Respiratory Syncytial Virus Prefusion F Protein Vaccine With 20-Valent Pneumococcal Conjugate Vaccine in Adults Aged ≥60 Years: A Randomized, Non-inferiority Trial.
This phase III, open-label, randomized non-inferiority trial compared concomitant versus one-month-apart administration of adjuvanted RSV prefusion F protein vaccine (RSVPreF3) and 20-valent pneumococcal conjugate…
Safety, Efficacy, and Immunogenicity of a Multivalent Adjuvanted Staphylococcus aureus Vaccine in Adults With Recent Skin and Soft Tissue Infections: An Observer-Blind, Randomized, Placebo-Controlled, Multinational Phase 1/2 Trial.
This observer-blind, randomized, placebo-controlled phase 1/2 trial evaluated a five-antigen Staphylococcus aureus vaccine with AS01E adjuvant in adults, including 194 participants aged 18–64 years with a recent S.
Systematic Review and Meta-Analyses of Time-Use, Productivity, and Labor Outcomes Among Unpaid Cancer Caregivers.
This systematic review and meta-analysis pooled evidence on time use and labor outcomes among unpaid caregivers of adults with cancer.
Sunitinib in Patients With Various Solid Tumors With FGFR1 / 2 Alterations: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study.
This phase II basket trial evaluated sunitinib in patients with advanced solid tumours and FGFR1 or FGFR2 alterations who had no remaining standard treatment options. Histology-specific cohorts were pooled by alteration.
Survival outcomes following total intravenous versus volatile anesthesia in esophagogastric cancer surgery: a systematic review and meta-analysis.
This systematic review and meta-analysis compared total intravenous anesthesia (TIVA) with volatile anesthesia in adults undergoing curative surgery for esophageal or gastric cancer.
T-cell-redirecting therapies in early relapsed multiple myeloma: a systematic review and network meta-analysis.
This systematic review and network meta-analysis compared T-cell-redirecting regimens in randomized phase 3 trials involving patients with multiple myeloma after at least one prior line.
Short- versus long-course antibiotic therapy in non-severe CAP in children: a systematic review and meta-analysis.
This systematic review and meta-analysis compared short-course (≤ 5 days) with longer (> 5 days) antibiotic therapy for non-severe community-acquired pneumonia in immunocompetent children.
EACTS Expert Consensus Document on aortic valve repair and valve-sparing aortic root replacement procedures.
This EACTS Expert Consensus Document critically reviews evidence on aortic valve repair and valve-sparing aortic root replacement for aortic regurgitation and proximal thoracic aortic aneurysms across age groups.
Anxiety and Depression in Athletes of Different Levels Without Current Injury: A Systematic Review With Meta-Analyses.
This systematic review and random-effects meta-analysis examined anxiety and depression in athletes across competitive levels, including those without current injury.
Efficacy of direct-acting antiviral regimens for acute HCV infection: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed interferon-free dual direct-acting antiviral regimens for acute or recently acquired HCV infection.
Acrokeratosis paraneoplastica (Bazex syndrome): a systematic review and quantitative analysis of 106 cases.
Acrokeratosis paraneoplastica (Bazex syndrome) is an obligate paraneoplastic dermatosis characterized by symmetrical acral psoriasiform lesions and nail dystrophy.
Dose response relationship of medical cannabis and symptom control in patients with pancreatic cancer: an analysis of the CANPAN trial.
This analysis of the CANPAN pilot waitlist-control randomized trial examined cannabis use, patient-reported outcome completion, and THC dose-response among 32 cannabis-naïve patients with newly diagnosed locally…
Chemotherapy backbone and outcomes of immune checkpoint inhibitor combinations across solid tumors: a pan-tumor network meta-analysis.
This systematic review and network meta-analysis examined phase II–III randomised trials comparing first-line immune checkpoint inhibitor (ICI) plus chemotherapy with chemotherapy alone across solid tumours, assessing…
Probable vestibular paroxysmia mimicking benign paroxysmal positional vertigo of the superior semicircular canal in the presence of a neurovascular conflict: a case report and review of the literature.
A 52-year-old woman presented with positional vertigo and was initially diagnosed with right superior semicircular canal benign paroxysmal positional vertigo (BPPV).
Managing 7-Hydroxymitragynine Use Disorder with Buprenorphine-Naloxone.
A patient who had used kratom to stop illicit opioids developed tolerance and transitioned to 7-hydroxymitragynine, believing the plant-derived product was safe.
Effect of a Single Subanesthetic Dose of Esketamine on Gastrointestinal Recovery After Laparoscopic Colorectal Cancer Surgery: A Randomized, Outcome-Assessor-Blinded, Placebo-Controlled Trial.
Postoperative gastrointestinal dysfunction (POGD) and Postoperative gastrointestinal intolerance (POGI) remain a critical challenge in abdominal surgery, particularly for colorectal cancer patients undergoing…
Prospective controlled study of the recombinant zoster vaccine in autoimmune rheumatic disease: robust seroconversion despite intravenous cyclophosphamide.
This subanalysis of a prospective, randomized, placebo-controlled trial assessed recombinant zoster vaccine (RZV) responses in patients with autoimmune rheumatic disease receiving intravenous cyclophosphamide (IVCYC)…
Multiple Sclerosis During Pregnancy and the Postpartum Period: Diagnostic and Multidisciplinary Challenges in Two Cases.
The report describes two pregnant women with progressive focal neurological symptoms and brain MRI abnormalities concerning for central nervous system demyelination.
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