Trending archive
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1719 articles
October 202624
Prednisone in the Management of Pericarditis: A Systematic Review.
This systematic review evaluated the use of oral corticosteroids, primarily prednisone, in adults with acute or recurrent pericarditis.
Lenalidomide-Related Diarrhea in Patients with Multiple Myeloma Is Associated with Gut Microbiota Dysbiosis and Disruption of the Bile Acid Pool.
This Phase II randomized controlled trial investigated the relationship between gut microbiota dysbiosis, bile acid pool disruption, and lenalidomide-related diarrhea (LRD) in patients with multiple myeloma.
Efficacy and Safety of Lorundrostat for Uncontrolled and Treatment-resistant Hypertension: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
This systematic review and meta-analysis evaluated the efficacy and safety of lorundrostat in adults with uncontrolled or treatment-resistant hypertension.
Efficacy and Safety of CETP Inhibitors in Patients With Atherosclerotic Cardiovascular Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
This systematic review and meta-analysis evaluated the efficacy and safety of cholesteryl ester transfer protein (CETP) inhibitors in 62,565 patients with atherosclerotic cardiovascular disease.
Meningococcal meningitis in patients under prolonged eculizumab therapy: Clinical and immunological observations from a case series.
Two patients undergoing prolonged eculizumab therapy developed meningococcal meningitis despite prior vaccination. The clinical presentation included typical symptoms of meningitis, and diagnostic workups confirmed the…
First reported case of peritoneal dialysis-associated peritonitis caused by Citrobacter sedlakii.
A 31-year-old female patient undergoing peritoneal dialysis presented with recurrent peritonitis. The infection was identified as being caused by Citrobacter sedlakii, a rare gram-negative bacillus.
Pediatric Guillain-Barré Syndrome Post Organ Transplant: Acute and Chronic Complication Requiring High Index of Suspicion.
Two pediatric patients developed Guillain-Barré syndrome (GBS) following organ transplantation. The first patient experienced rapid weakness post-liver transplant amid organ failure and adenovirus infection, showing…
Back-Table Reduction of a Deceased Adult Donor Kidney for Transplantation Into a Small Child: A Six-Year Follow Up.
A 15-month-old boy with congenital nephrotic syndrome received a left kidney from a 46-year-old deceased donor. Due to size mismatch, the upper pole of the kidney was resected ex vivo, reducing its volume by one-third.
Pediatric Spinal Cord Astrocytoma With Granular Cell-Like Morphology and KIAA1549::BRAF Fusion.
A pediatric patient presented with a spinal cord tumor exhibiting prominent granular cell-like features, complicating the initial diagnosis.
Effects of Yoga on Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the effects of yoga on psychological function and inflammation in individuals with rheumatoid arthritis (RA).
A Novel BORCS5 Loss-Of-Function Variant in a Patient With a Rare Neurodevelopmental Disorder.
The BORCS5 is an important and critical component of the BLOC-one-related complex (BORC), involved in kinesin-dependent anterograde lysosomal transport.
Gestational Choriocarcinoma With Inferior Vena Cava Tumor Thrombus Formation.
A 52-year-old woman presented with recurrent nausea and vomiting, leading to the discovery of elevated serum β-hCG levels and a pelvic mass extending into the inferior vena cava (IVC).
Identification of Variants in Two Families With Congenital Cataract by Whole Exome Sequencing.
Congenital cataract (CC) is an ophthalmic disorder diagnosed at birth or during early infancy, characterized by severe visual impairment and potential blindness.
A Novel De Novo MTM1 Insertion Frameshift Variant Causes X-Linked Myotubular Myopathy in a Chinese Female.
A 24-year-old woman presented with infantile hypotonia and progressive, asymmetric proximal weakness, including facial and ocular involvement.
TMS-Derived Neurophysiological Measures of Corticospinal Excitability, Intracortical Excitability, and Interhemispheric Interactions Associated With Post-Stroke Motor Recovery: A Systematic Review.
This systematic review evaluated the relationship between TMS-derived neurophysiological measures and motor recovery in adults post-stroke, synthesizing data from 16 randomized controlled trials.
Health Economic & Implementation Determinants of Prehospital Stroke Triage Tools: A Systematic Review.
This systematic review evaluated health economic outcomes and implementation determinants of prehospital triage tools for suspected ischaemic stroke patients.
Phase 1 dose escalation and expansion trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein SL-172154 (SIRPα-Fc-CD40L) in patients with higher-risk myelodysplastic syndrome or acute myeloid leukemia.
This Phase I clinical trial evaluated the safety and efficacy of the bispecific CD47 inhibitor SL-172154 combined with azacitidine (AZA) in patients with higher-risk myelodysplastic syndrome (HR-MDS) or acute myeloid…
Variants in CEP135 Cause Congenital Microcephaly and Primary Ciliary Dyskinesia.
Three children from two families presented with congenital microcephaly and chronic respiratory issues consistent with primary ciliary dyskinesia (PCD). Diagnostic testing revealed autosomal recessive variants in CEP135.
Gut microbiome and healthy ageing: a systematic review of literature.
This systematic review examined the gut microbiome's compositional and functional features associated with healthy ageing, independent of age-related diseases.
Screening Strategies for Silent Myocardial Ischemia in Individuals With Diabetes Without Known Coronary Artery Disease: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the effectiveness of routine screening for silent myocardial ischemia in asymptomatic adults with diabetes and no known coronary artery disease.
Tumor Profile, Clinical Features, and Outcomes in Individuals With Constitutional Trisomy 8: A Systematic Review of Case Reports and Case Series.
Constitutional trisomy 8 mosaicism (CT8M) is a rare chromosomal disorder with poorly characterized cancer risk. This systematic review aimed at summarizing reported cases of malignancy and associated clinical outcomes…
Mosaicism for Cohen-Gibson Syndrome in a Female Individual With Overgrowth and Neurodevelopmental Delay.
A 12-year-old girl presented with tall stature, dysmorphic features, developmental delay, and congenital anomalies. Genetic evaluation revealed a likely pathogenic mosaic variant in the EED gene, with varying allele…
Iran's Escherichia coli AMR Landscape (2010-2025): A One Health Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined the prevalence of antimicrobial resistance (AMR) in Escherichia coli across humans, animals, foods, and the environment in Iran from 2010 to 2025.
A Case of Primary Intramedullary Infantile Fibrosarcoma With an RBPMS::NTRK3 Fusion and Response to Larotrectinib.
A 4-week-old infant presented with rapidly progressive cervical myelopathy due to primary intramedullary infantile fibrosarcoma.
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