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1386 articles

October 202624

Clinical ResearchGeriatricsOpen access

Can Photobiomodulation improve healing of category II-III pressure ulcers in frail older adults? A quasi-experimental 24-month follow-up study.

This quasi-experimental study compared adjunctive photobiomodulation with standard care for category II and III pressure ulcers in frail adults aged 70 years or older receiving municipal home healthcare.

PLoS OneOct 28, 2026Read summary
Clinical ResearchInfectious DiseasesOpen access

A Bayesian Re-analysis of the GALFLU Trial of High-Dose vs Standard-Dose Influenza Vaccine Against Hospitalization Outcomes.

This Bayesian re-analysis examined hospitalization outcomes in the GALFLU randomized trial, which compared high-dose with standard-dose inactivated influenza vaccine in adults aged 65–79 years.

Clin Infect DisOct 28, 2026Read summary
Clinical ResearchAnesthesiology

Haemodynamic and Respiratory Effects of Dexmedetomidine as an Adjuvant to Oxycodone Patient-Controlled Analgesia After Lumbar Spinal Fusion: A Post Hoc Analysis of the DoseRespDex Randomised Controlled Trial.

This post hoc analysis of a randomised, double-blind, placebo-controlled trial examined haemodynamic and respiratory effects of dexmedetomidine added to oxycodone patient-controlled analgesia in 98 adults undergoing…

Acta Anaesthesiol ScandOct 27, 2026Read summary
Clinical ResearchOncology (Medical)

Zamtocabtagene autoleucel, a tandem CD20-CD19-directed CAR T-cell therapy, for second line treatment of large B-cell lymphoma in patients ineligible for transplantation (DALY 2-EU): primary analysis of an open-label, multicentre, randomised phase 2 study.

DALY 2-EU was an open-label, multicentre, randomised phase 2 trial comparing tandem CD20-CD19-directed zamtocabtagene autoleucel (zamto-cel) with R-GemOx in adults with second-line relapsed or refractory large B-cell…

Lancet OncolOct 27, 2026Read summary
Clinical ResearchPreventive Medicine / Public Health

Effects of Whey Protein Supplementation on Muscle Damage, Hepatic Stress, and Inflammatory Markers in Power- and Endurance-Trained Athletes.

This randomized, double-blind, placebo-controlled trial examined 8 weeks of whey protein supplementation (30 g/day) in 59 male power- and endurance-trained athletes.

Eur J Sport SciOct 27, 2026Read summary
Clinical ResearchPsychiatry

Combining Cognitive Training and Brain Stimulation: A Novel Approach to Address Disordered Eating and Antipsychotic-Induced Weight Gain in People With Severe Mental Illness.

This double-blind, parallel-group, sham-controlled randomised trial assessed the feasibility of combining Approach Bias Modification Training (ABMT) with real or sham transcranial direct current stimulation (tDCS) in…

Early Interv PsychiatryOct 27, 2026Read summary
Clinical ResearchOncology (Medical)

Efficacy and Safety of Apixaban Thromboprophylaxis According to Baseline Chemotherapy Class in High-Risk Ambulatory Cancer Patients: A Post Hoc Analysis of the AVERT Trial.

This post hoc analysis of the randomized, double-blind AVERT trial examined apixaban thromboprophylaxis by baseline chemotherapy class in 563 ambulatory patients with cancer starting chemotherapy.

Cancer MedOct 27, 2026Read summary
Clinical ResearchCardiology

Four weeks of isometric handgrip training results in lower awake ambulatory blood pressure compared with control: a randomized clinical trial.

This randomized controlled trial compared handgrip and knee-extension isometric training with control in 67 adults with controlled hypertension receiving antihypertensive medication.

Clin Physiol Funct ImagingOct 27, 2026Read summary
Case ReportObstetrics & Gynecology

Vaginal Angiomyofibroblastoma in a Patient With Warkany Syndrome (Mosaic Trisomy 8): A Case Report.

A 27-year-old nulliparous woman with constitutionally confirmed mosaic trisomy 8 presented with a protruding vaginal mass. MRI showed a well-defined, homogeneously enhancing mid-vaginal lesion and incidentally…

J Obstet Gynaecol ResOct 27, 2026Read case
Clinical ResearchInfectious DiseasesOpen access

Rare and Novel Hepatitis C Virus Genotype Subtypes and Response to Sofosbuvir/Velpatasvir in A5360 (MINMON) Clinical Trial.

This analysis of samples from the multicountry ACTG A5360 (MINMON) clinical trial characterized rare and novel hepatitis C virus (HCV) subtypes and assessed baseline resistance-associated substitutions and response to…

J Viral HepatOct 27, 2026Read summary
Clinical ResearchPediatrics

Endobronchial Valves for Persistent Air Leak and Bronchopleural Fistula in Children: A Systematic Review of Indications, Procedural Approaches, and Outcomes.

This systematic review examined bronchoscopic endobronchial or intrabronchial valve placement for persistent air leak, bronchopleural fistula, or pneumothorax with ongoing air leak in children and late adolescents.

J Bronchology Interv PulmonolOct 27, 2026Read summary
Clinical ResearchPulmonology

Comparison of the Safety and Efficacy of Remimazolam for Sedation in Adults Undergoing Fiberoptic Bronchoscopy: A Meta-Analysis of Randomized Controlled Trials.

This systematic review and meta-analysis of randomized controlled trials compared remimazolam with other sedatives in adults undergoing fiberoptic bronchoscopy.

J Bronchology Interv PulmonolOct 27, 2026Read summary
Clinical ResearchObstetrics & Gynecology

Effectiveness of theory-based educational interventions on fertility and childbearing intentions: a systematic review and meta-analysis among Iranian populations.

This systematic review and meta-analysis assessed theory-based educational interventions and fertility or childbearing intentions among Iranian populations.

Hum Fertil (Camb)Oct 27, 2026Read summary
Clinical ResearchNeurology

Measuring the impact of migraine: a systematic review of the measurement properties of MIDAS, HIT-6, and MSQoL.

This systematic review compared the measurement properties of MIDAS, HIT-6, and MSQoL for assessing migraine impact. Following COSMIN methods, it included 22 studies with 20,455 participants.

Arq NeuropsiquiatrOct 27, 2026Read summary
Case ReportInternal Medicine (General)

A 58-Year-Old Woman with Abdominal Pain, Fever, and Cough.

A 58-year-old woman presented with fever, abdominal pain, and a nonproductive cough. The report describes a diagnostic evaluation using focused history, physical examination, and testing, with the differential diagnosis…

NEJM EvidOct 27, 2026Read case
Clinical ResearchInfectious Diseases

Next-Generation Bed Nets to Control Malaria in Côte d'Ivoire.

This cluster-randomized clinical trial compared pyrethroid-only long-lasting insecticidal nets with piperonyl butoxide-pyrethroid (PBO-py) and chlorfenapyr-pyrethroid (CFP-py) nets in villages in Côte d'Ivoire.

NEJM EvidOct 27, 2026Read summary
Clinical ResearchPreventive Medicine / Public Health

E-Cigarettes with and without Behavioral Support for Smoking Cessation.

This randomized controlled trial compared an e-cigarette starter pack alone, the starter pack plus multisession telephone-based behavioral support, and automated supportive messages among people who smoked and were…

NEJM EvidOct 27, 2026Read summary
Clinical ResearchOrthopedic Surgery

Comparative effectiveness of three splints for rehabilitation after finger flexor tendon repair (FIRST): randomised controlled trial.

The FIRST pragmatic, multicentre randomised trial compared forearm-based long, Manchester short, and relative motion flexion mini splints for rehabilitation after primary zone 1 or 2 finger flexor tendon repair.

BMJOct 27, 2026Read summary
Clinical ResearchCardiology

Effectiveness of Wrist-Worn Wearable-Guided Cardiac Rehabilitation Delivered Through Fully Remote or Hybrid Programs in Patients With Cardiovascular Disease: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

This systematic review and meta-analysis assessed randomized trials of wrist-worn wearable-guided cardiac rehabilitation delivered remotely or in hybrid formats during phase II or III rehabilitation for adults with…

JMIR Mhealth UhealthOct 27, 2026Read summary
Clinical ResearchPsychiatry

Purrble Use Among LGBTQ+ Young People With Self-Harm Experiences: Findings From a Qualitative Process Evaluation of a Randomized Controlled Trial.

This qualitative process evaluation explored how LGBTQ+ young people with self-harm experiences used and perceived Purrble, a socially assistive robot evaluated in a related randomized controlled trial.

JMIR Form ResOct 27, 2026Read summary
Clinical ResearchInfectious Diseases

Assessing stigma and perceptions of respectful care in Malawi's index case testing program: Findings from a cluster randomized controlled trial.

This cluster randomized controlled trial assessed whether enhanced stigma-reduction training improved healthcare worker (HCW) attitudes and client experiences in Malawi’s HIV index case testing program.

PLoS OneOct 27, 2026Read summary
Case ReportAllergy & Immunology

Disruption of the N-terminal domain in a STAT3 hyper-IgE syndrome variant causes disease by sequestering STAT3 in the cytoplasm.

A patient with a STAT3 R31Q variant presented with disseminated invasive aspergillosis involving the brain and lung, bronchiectasis, and elevated serum IgE, without nonimmune manifestations of hyper-IgE syndrome.

Sci SignalOct 27, 2026Read case
Clinical ResearchOrthopedic Surgery

Evaluating treatment efficacy for Iliotibial Band Syndrome: A comparison of combined foam rolling and stretching with strengthening exercises versus strengthening alone in athletes.

This randomized controlled trial compared strengthening alone with strengthening plus foam rolling and stretching in 20 athletes with confirmed iliotibial band syndrome.

PLoS OneOct 27, 2026Read summary
Clinical ResearchNeurology

Is resistance training effective to increase BDNF in multiple sclerosis? An updated systematic review and meta-analysis of isolated interventions.

This systematic review and meta-analysis examined whether isolated resistance training (RT) affects peripheral brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis (MS).

PLoS OneOct 27, 2026Read summary

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