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751 articles
August 202624
Food-derived extracellular vesicles as delivery platforms for medicine-food homology components in metabolic syndrome.
This systematic review examines the role of food-derived extracellular vesicles (FDEVs) as delivery systems for medicine-food homology components (MFHCs) in managing diet-induced obesity and metabolic syndrome.
Mobile health apps improve Health-Related Quality of Life in Type 2 Diabetes Mellitus by enhancing medication adherence: A multicentre randomised controlled trial with mediation analysis.
This multicentre randomized controlled trial evaluated the impact of the gamified mHealth application CareAide® on Health-Related Quality of Life (HRQoL) in 663 patients with Type 2 Diabetes Mellitus.
Once-weekly IcoSema versus once-daily insulin glargine U100 in type 2 diabetes management (COMBINE 4): an open-label, multicentre, treat-to-target, randomised, phase 3b trial.
The COMBINE 4 trial evaluated the efficacy and safety of once-weekly IcoSema versus once-daily insulin glargine U100 in adults with type 2 diabetes inadequately controlled on oral medications.
Liraglutide and Βeta-Cell Function in Young Adults With Long-Standing Type 1 Diabetes and Residual C-Peptide: A Blinded, Randomized Controlled Trial.
This blinded, randomized, placebo-controlled trial assessed whether liraglutide preserved residual beta-cell function in 18 adults with type 1 diabetes of at least 5 years’ duration and detectable fasting C-peptide.
Comparative efficacy and thyroid function effects of non-surgical treatments for benign thyroid nodules: a Bayesian network meta-analysis.
This Bayesian network meta-analysis evaluated the efficacy of non-surgical treatments for benign thyroid nodules in 545 adults.
Duration and characteristics of hypoglycemia with once-weekly insulin efsitora alfa versus once-daily basal insulins in adults with type 2 diabetes: Exploratory safety analysis of QWINT 2-4.
This randomized controlled trial explored the duration and characteristics of hypoglycemia in adults with type 2 diabetes treated with once-weekly insulin efsitora versus once-daily basal insulins.
From pathobiology to prescribing in obesity-driven HFpEF: A systematic review and practical therapeutic framework.
This systematic review evaluates pharmacological therapies for obesity-driven heart failure with preserved ejection fraction (HFpEF).
Effects of bedtime melatonin treatment on blood pressure and arterial stiffness: a three-month, randomized, placebo-controlled crossover study in individuals with type 2 diabetes mellitus.
This double-blinded, randomized, placebo-controlled crossover trial examined whether bedtime melatonin affects blood pressure and arterial stiffness in people with type 2 diabetes, with or without hypertension.
Contemporary automated insulin delivery systems in older adults with type 1 diabetes: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness of automated insulin delivery (AID) systems in adults aged 60 years and older with type 1 diabetes.
Financial incentives and health coaching to improve glycemic outcomes among young adults with type 1 diabetes: A factorial randomized trial (SweetGoals).
This randomized controlled trial evaluated the impact of financial incentives and web health coaching on glycemic control in 300 young adults with type 1 diabetes over 12 months.
Analytically accurate, clinically inaccurate: A diagnostic case of Pseudohyperparathyroidism.
A 33-year-old kidney transplant recipient with prior secondary hyperparathyroidism treated by parathyroidectomy had a PTH result above the assay’s analytical measurement range, despite normal serum calcium and…
Effectiveness of digital and telemedicine interventions for gestational diabetes mellitus: An umbrella review of systematic reviews and meta-analyses.
This umbrella review synthesized 24 systematic reviews covering 144 primary studies and 41,384 participants to assess digital and telemedicine interventions for gestational diabetes mellitus.
Efficacy and safety of once-weekly semaglutide 2·4 mg in Chinese adults with overweight or obesity (STEP 12): a randomised, double-blind, placebo-controlled, multicentre, phase 3b trial.
This phase 3b randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of once-weekly semaglutide 2.4 mg in Chinese adults with overweight or obesity.
High-animal protein and high-plant protein meals differentially alter postprandial plasma amino acid concentrations but not glucose homeostasis in people with overweight/obesity in a randomized, crossover, single-meal study.
This randomized crossover trial examined the effects of high-animal protein (HAP) and high-plant protein (HPP) meals on postprandial plasma amino acid and glucose levels in individuals with overweight/obesity.
Small intestinal compared with colonic short-chain fatty acid delivery drives distinct systemic concentrations and endocrine responses in humans: a randomized, crossover trial.
This randomized, crossover trial investigated the effects of short-chain fatty acid (SCFA) delivery to the small intestine versus the colon in 28 healthy adults.
Feasibility and Effects of a Produce Prescription Program (PRx) in People With Type 2 Diabetes and Low Socioeconomic Status: A Randomised Controlled Pilot Trial.
This 3-month randomised controlled pilot trial in primary care in Rotterdam assessed the feasibility and potential effects of a produce prescription program in adults with type 2 diabetes, BMI > 25 kg/m² and low…
Impact of glucagon-like peptide-1 receptor agonists on outcomes following anterior cervical discectomy and fusion: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the impact of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on outcomes following anterior cervical discectomy and fusion (ACDF) in a cohort of 311,402 patients.
Cost Effectiveness of Teriparatide for Postmenopausal Osteoporosis: A Systematic Review.
This systematic review evaluated the cost effectiveness of teriparatide for postmenopausal osteoporosis, analyzing 22 economic evaluations.
Effect of semaglutide on kidney outcomes in the SELECT, FLOW, and SOUL trials: a prespecified pooled analysis.
This pooled analysis of participant-level data from the SELECT, FLOW, and SOUL trials evaluated the effects of semaglutide on kidney outcomes in individuals with type 2 diabetes and chronic kidney disease.
Efficacy and tolerability of mirogabalin, pregabalin, duloxetine, and placebo in patients with type 2 diabetes mellitus and painful diabetic peripheral neuropathy: A network meta-analysis.
This network meta-analysis evaluated the efficacy and tolerability of mirogabalin, pregabalin, and duloxetine in treating painful diabetic peripheral neuropathy (PDPN) in patients with type 2 diabetes mellitus (T2DM).
Effect of levothyroxine therapy on albuminuria and glomerular function in patients with type 2 diabetes and subclinical Hypothyroidism: a randomized controlled pilot trial.
This randomized controlled pilot trial evaluated the impact of levothyroxine therapy on renal outcomes in 60 adults with type 2 diabetes and subclinical hypothyroidism over 6 months.
Analysis of the efficacy and safety of liraglutide, semaglutide, and tirzepatide for the treatment of overweight and obesity: a systematic review and network meta-analysis.
This systematic review and network meta-analysis evaluated the efficacy and safety of liraglutide, semaglutide, and tirzepatide in adults with a BMI ≥ 25 kg/m² over a duration of at least 52 weeks.
Efficacy and Hypoglycaemia Outcomes With Once-Weekly IcoSema Versus Comparators in Individuals With Type 2 Diabetes by Kidney and Liver Function: A Post Hoc Analysis of the COMBINE 1-3 Trials.
This post hoc analysis of the COMBINE 1-3 trials evaluated the efficacy and hypoglycaemia outcomes of IcoSema in adults with type 2 diabetes, focusing on kidney and liver function subgroups.
Aspirin hyporesponsiveness in type 2 diabetes mellitus: A systematic review with narrative synthesis of definitions, assessment methods, and clinical relevance.
This systematic review evaluated aspirin hyporesponsiveness in patients with type 2 diabetes mellitus (T2DM), analyzing 21 studies.
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