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441 articles
June 202611
The effects of acute ketone monoester supplementation on brain insulin responsiveness and cognitive performance: Results of a randomized, double-blind, placebo-controlled crossover trial in older men with overweight.
This randomized, double-blind, placebo-controlled crossover trial examined the effects of acute ketone monoester (KME) supplementation on brain insulin responsiveness and cognitive performance in 18 older men with…
Insomnia and inflammatory exposure impair spatial memory and cognitive mapping in older adults: a randomized controlled trial.
This randomized controlled trial investigated the impact of insomnia and inflammatory exposure on spatial memory and cognitive mapping in 84 older adults aged 60-80.
Prevalence of osteosarcopenia in postmenopausal women: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed the prevalence of osteosarcopenia (OSP) in postmenopausal women, analyzing data from 16 studies involving 7,631 participants.
Effect of a digital mindfulness intervention for mild-to-moderate late-life depression: A randomized controlled trial.
This randomized controlled trial evaluated the FocusZen Mindfulness Stress Reduction System in 54 older adults with mild-to-moderate late-life depression (LLD).
Body mass index and baricitinib treatment effect in hospitalized adults with COVID-19: A secondary analysis of ACTT-2.
This secondary analysis of the ACTT-2 randomized controlled trial evaluated the impact of body mass index (BMI) on the efficacy of baricitinib in hospitalized COVID-19 patients.
User engagement with digital health technologies among older adults with cancer: A systematic review and qualitative evidence synthesis.
This systematic review synthesized qualitative evidence on user engagement with digital health technologies among older adults with cancer.
Economic Evaluation of Self-Administered Dual-Task Training Reducing Falls in Community-Dwelling Older Adults: Cost-Effectiveness Analysis of a Multicenter Randomized Control Trial.
This multicenter randomized controlled trial evaluated the cost-effectiveness of self-administered dual-task training (sDT) versus single-task training (sST) in preventing falls among 216 community-dwelling older adults…
Androgen therapy and musculoskeletal health in older adults: An umbrella review.
This umbrella review synthesized evidence from 11 systematic reviews and meta-analyses of randomized clinical trials assessing androgen therapy in older adults (≥60 years).
Effects of exercise on metabolic risk, cardiovascular fitness, and body composition in elderly women of the past decade: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effects of exercise on metabolic risk, cardiovascular fitness, and body composition in healthy elderly women.
Interventions to Reduce Loneliness in Informal Caregivers of People With Dementia: A Systematic Review.
This systematic review evaluated interventions aimed at reducing loneliness in informal caregivers of dementia patients. Eight studies were analyzed, with three being randomized controlled trials.
A pragmatic randomized trial to evaluate the vaccine effectiveness of bivalent RSV prefusion F vaccine for preventing RSV hospitalizations in adults (DAN-RSV): Trial design update.
The DAN-RSV trial is a pragmatic randomized controlled trial assessing the effectiveness of the bivalent RSV prefusion F vaccine in preventing RSV-related hospitalizations among adults.
May 202613
Mental Health Stereotypes and Aging: Effects on Mood and Decision Making.
This randomized controlled trial examined the impact of negative aging stereotypes on the mood, risk tolerance, and patience of older adults (mean age = 68.9).
Pharmacological and non-pharmacological treatments for chronic insomnia in perimenopausal and postmenopausal women: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated pharmacological and non-pharmacological treatments for chronic insomnia in perimenopausal and postmenopausal women.
Safety and durability of influenza and SARS-CoV-2 antibody responses through 6 months after a single dose of mRNA-1083, a multicomponent influenza and COVID-19 vaccine, in adults ≥50 years.
This phase 3 randomized controlled trial evaluated the safety and immunogenicity of mRNA-1083, a multicomponent vaccine for influenza and SARS-CoV-2, in adults aged ≥50 years.
Physical therapy for urinary incontinence in older women: A systematic review.
This systematic review evaluated randomized controlled trials of physical therapy interventions for urinary incontinence in women aged 60 and older.
Risk factors for suicidal behaviour in people with dementia: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the risk factors for suicidal behavior in people with dementia (PwD). It found that PwD have a 62% increased risk of suicidal behavior compared to non-dementia controls…
Cannabinoids Treatment for Agitation in Alzheimer's Disease: A Systematic Review and Meta-Analysis With Bayesian and Sequential Trial Analyses.
This systematic review and meta-analysis evaluated the efficacy and safety of cannabinoid-based therapies for agitation in Alzheimer's disease, involving 221 participants across seven studies.
Effect of exercise interventions on hand grip and TUG in older adults: A network meta-analysis of randomized controlled trials.
This network meta-analysis evaluated the effects of various exercise interventions on hand grip strength and functional mobility in older adults.
Wearable devices for improving medication adherence in older adults with chronic conditions: A systematic review.
This systematic review evaluated the impact of wearable devices on medication adherence in adults aged 65 and older with chronic conditions.
Efficacy and safety of donanemab in the European eligible population: TRAILBLAZER-ALZ 2 post-hoc analyses.
This post-hoc analysis of the TRAILBLAZER-ALZ 2 trial evaluated the efficacy and safety of donanemab in European Union-eligible patients with early symptomatic Alzheimer's disease.
Supporting Physical Activity and Quality of Life in Older Adults with Coronary Heart Disease: Development of a Web-Based Nursing Intervention.
This clinical trial describes the development of 'Changeons ensemble', a web-based nursing intervention aimed at promoting physical activity and quality of life in older adults with coronary heart disease (CHD).
Applying Implementation Science Methods to Prospectively Track the Adaptation of an Evidence-Based Deprescribing Intervention for Use in a New Health System and Country.
This pragmatic clinical trial evaluated the adaptation of the STOP-FALLS deprescribing intervention for older adults within the Kaiser Permanente Washington health system.
Advantages of artificial saliva containing Cuminum cyminum and Zingiber officinale on hemodialysis patients with xerostomia: Randomized clinical trials.
This randomized controlled trial evaluated the efficacy and safety of herbal artificial saliva (HAS) containing cumin and ginger in hemodialysis patients with xerostomia.
Osteoporotic fractures prevalence in Latin American countries: A systematic review of literature and meta-analysis.
This systematic review and meta-analysis examined the prevalence of osteoporotic fractures (OF) in Latin America, analyzing data from 22 studies involving 1,182,219 participants.
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