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441 articles
October 202621
Effects of remimazolam versus propofol on cerebral oxygenation in elderly patients undergoing prone spine surgery: study protocol for a randomised controlled trial.
This article describes the protocol for a prospective, single-centre randomised controlled trial comparing remimazolam with propofol-based total intravenous anaesthesia in elderly patients undergoing elective thoracic…
Dose- and modality-specific effects of exercise on BDNF and depression in middle-aged and older adults with mild cognitive impairment: A Bayesian network meta-analysis.
This Bayesian network dose-response meta-analysis examined randomized controlled trials of exercise in adults aged 50 years or older with mild cognitive impairment (MCI), assessing peripheral brain-derived neurotrophic…
Immunogenicity and Safety of the Adjuvanted Respiratory Syncytial Virus Prefusion F Protein-Based Vaccine When Co-administered With the Adjuvanted Recombinant Herpes Zoster Subunit Vaccine in Adults ≥ 50 Years of Age.
This phase III, open-label, randomised trial compared co-administration of adjuvanted RSVPreF3 and recombinant zoster vaccine (RZV) with administration one month apart in adults aged ≥50 years.
Immunogenicity and Safety of Co-administration of Adjuvanted Respiratory Syncytial Virus Prefusion F Protein Vaccine With 20-Valent Pneumococcal Conjugate Vaccine in Adults Aged ≥60 Years: A Randomized, Non-inferiority Trial.
This phase III, open-label, randomized non-inferiority trial compared concomitant versus one-month-apart administration of adjuvanted RSV prefusion F protein vaccine (RSVPreF3) and 20-valent pneumococcal conjugate…
Effectiveness of psychosocial interventions addressing informal caregivers' mental health: an umbrella systematic review with 26,481 participants.
This umbrella systematic review and random-effects meta-analysis assessed psychosocial interventions for the mental health of informal caregivers, grouped by care recipients’ clinical conditions.
Neuromuscular, Balance, and Gait Factors Associated with Falls and Fall-Related Outcomes in Individuals with COPD: A Systematic Review.
This systematic review examined associations between muscle strength, balance, gait and falls or fall-related outcomes in people with COPD. It included 25 original studies involving 1295 participants.
Electroacupuncture Targeting the NLRP3 Inflammasome in Senescence‑associated Cognitive Impairment: Mechanistic Synthesis and Meta‑analysis of Clinical Randomized Controlled Trials.
This meta-analysis reviewed nine randomized controlled trials involving 614 participants to evaluate the effects of electroacupuncture on senescence-associated cognitive impairment (SACI).
Adjunctive neuromuscular electrical stimulation and cognitive-motor interference during gait in older inpatients.
This exploratory analysis of a pragmatic pilot trial examined whether adjunctive neuromuscular electrical stimulation (NMES) was associated with changes in cognitive-motor interference during gait among older inpatients…
Vitamin D Supplementation and Mortality in the Elderly: A Review of a Meta-Analysis of Randomized Controlled Trials Using the REB Method.
This meta-analysis reviewed 25 randomized controlled trials (RCTs) to evaluate the impact of vitamin D supplementation on mortality in individuals aged 75 and older.
Should I drink water or wine? Impacts of online nutritional counseling on the alcohol consumption of elderly individuals with mild cognitive impairment : Secondary Data Analysis from the RCT "BrainFit-Nutrition".
This secondary data analysis from a randomized controlled trial evaluated the effects of nutritional counseling on alcohol consumption in 189 elderly individuals with mild cognitive impairment (MCI) over 12 months.
Prevalence of metabolic syndrome among patients with Alzheimer disease: A systematic review and meta-analysis.
This systematic review and meta-analysis examined the prevalence of metabolic syndrome (MetS) in patients with Alzheimer disease (AD).
Cerebrospinal fluid shunting for idiopathic normal pressure hydrocephalus: a comprehensive meta‑analysis with trial sequential analysis of randomized controlled trials.
This meta-analysis evaluated the efficacy of cerebrospinal fluid (CSF) shunting in adults aged 60 and older with idiopathic normal pressure hydrocephalus (iNPH).
Incidence, severity, and associated risk factors for amyloid-related imaging abnormalities in anti-amyloid monoclonal antibody therapy for early Alzheimer's disease: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the incidence and risk factors for amyloid-related imaging abnormalities (ARIA) in 12,610 patients with early Alzheimer's disease receiving anti-amyloid monoclonal…
Association of Sarcopenia With Global, Motor, Cognitive, and Swallowing Function Prognosis in Stroke Patients: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the impact of sarcopenia on functional outcomes in stroke patients. Analyzing 36 cohort studies, it found that patients with sarcopenia had a significantly higher risk…
Multidisciplinary Treatment With Repeated Thermal Ablation for Multisite Metastatic Colon Cancer in an Elderly Patient.
An 81-year-old woman with a history of myocardial and cerebral infarctions presented with metastatic colon cancer, including multiple liver and ovarian metastases.
Perioperative Safety and Effectiveness of Laparoscopic Heller Myotomy in Elderly Patients: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the perioperative safety and effectiveness of laparoscopic Heller myotomy (LHM) in patients aged 65 years or older.
Factors influencing access to green health prescribing in primary care for older adults - a qualitative systematic review.
This systematic review examined barriers and enablers to green health prescribing (GHP) for older adults with long-term conditions.
Gut microbiome and healthy ageing: a systematic review of literature.
This systematic review examined the gut microbiome's compositional and functional features associated with healthy ageing, independent of age-related diseases.
Short-Term Effects of a Self-Monitoring-Based Intervention on Prolonged Sedentary Behavior in Older Adults With Cardiovascular Conditions: An Exploratory Secondary Analysis of a Randomized Controlled Trial.
This exploratory secondary analysis of a randomized controlled trial examined the impact of an accelerometer-guided self-monitoring intervention on prolonged sedentary behavior in older adults with cardiovascular…
Efficacy and Safety of Traditional Chinese Medicine in Treating Chronic Obstructive Pulmonary Disease with Osteoporosis: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of traditional Chinese medicine (TCM) as an adjunct to conventional treatment for chronic obstructive pulmonary disease (COPD) with osteoporosis…
Prevalence and Predictors of Depressive Symptom Trajectories in Older Adults: A Systematic Review.
This systematic review examined longitudinal patterns of depressive symptoms and their predictors among adults aged 60 years or older.
September 20263
Saprochaete pneumonia presenting as septic shock in an elderly patient with poorly controlled diabetes mellitus.
An elderly woman with poorly controlled diabetes presented with community-acquired pneumonia, septic shock, and multi-organ dysfunction. Despite initial antibiotic treatment, her condition deteriorated.
Behavior Change and Compliance Outcomes of a Novel Web-Based Health Behavior Tool Integrated Into Certified Exercise Practitioner Services: Twelve-Week, Two-Arm, Randomized Pre-Post Trial.
This randomized controlled trial evaluated the impact of a web-based health behavior tool, the FESS questionnaire, on health behaviors in 41 older adults (median age 65) receiving services from certified exercise…
Knowledge Performance, User Experience, and Cybersickness With Immersive Virtual Reality for Tai Chi Movement-Encoding in Older Adults: Randomized Comparison Study.
This randomized controlled trial compared immersive virtual reality (VR) to 2D video instruction for Tai Chi movement-encoding in 106 community-dwelling older adults.
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