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751 articles
June 202624
Higher Maternal Body Mass Index Attenuates the Response to High-Dose Vitamin D Supplementation During Pregnancy: A Secondary Analysis of the Randomized Vitamin D Antenatal Asthma Reduction Trial (VDAART).
This secondary analysis of the randomized Vitamin D Antenatal Asthma Reduction Trial (VDAART) examined how maternal body mass index (BMI) affects the biochemical response to high-dose vitamin D supplementation during…
Tirzepatide Efficacy and Tolerability According to Early Weight Response: A Post Hoc Analysis of the SURMOUNT-1 and SURMOUNT-2 Trials.
This post hoc analysis of the SURMOUNT-1 and SURMOUNT-2 trials evaluated the efficacy and tolerability of tirzepatide in 2384 participants with obesity or overweight.
Cardiovascular Efficacy of GLP-1 Receptor Agonists by Kidney Function: An Updated Meta-Analysis of Randomized Trials Including the SOUL Trial.
This meta-analysis evaluated the cardiovascular efficacy of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in adults with type 2 diabetes or obesity, stratified by estimated glomerular filtration rate (eGFR).
Metabolic and vascular outcomes after transition to the MiniMed 780G system in adults ≥65 years with type 1 diabetes: a randomised, single-centre study.
This randomized controlled trial evaluated the MiniMed 780G system's effectiveness in adults aged ≥65 years with type 1 diabetes.
Effect of pasteurized Akkermansia muciniphila MucT on insulin sensitivity, body composition, and GLP-1 production in subjects with metabolic syndrome: impact of low baseline gut Akkermansia levels.
This randomized controlled trial evaluated the effects of pasteurized Akkermansia muciniphila MucT on insulin sensitivity and GLP-1 production in 142 adults with metabolic syndrome.
A randomized controlled trial of Kangfuxin Liquid for diabetic peripheral neuropathy.
This randomized controlled trial evaluated the efficacy and safety of Kangfuxin Liquid in patients with diabetic peripheral neuropathy (DPN).
Impact of oliceridine versus sufentanil on postoperative nausea and vomiting in patients undergoing thyroid surgery: a prospective, double-blind, randomized controlled trial.
This prospective, double-blind, randomized controlled trial evaluated the effects of oliceridine versus sufentanil on postoperative nausea and vomiting (PONV) in 232 patients undergoing thyroid surgery.
Semaglutide for the Silent Phenotype: A Translational Signal in Obesity-Driven HFpEF.
This systematic review and meta-analysis evaluated the effects of semaglutide in adults with obesity-related heart failure with preserved ejection fraction (HFpEF).
Prospective study on the [ 18 F]FDOPA PET/CT role in the management of medullary thyroid cancer patients with high residual calcitonin level after surgery.
This multicenter prospective study evaluated the role of [18F]FDOPA PET/CT in managing medullary thyroid cancer (MTC) patients with high residual calcitonin levels post-surgery.
Ghrelin predicts food consumption up to three hours prior to eating: A randomised controlled trial.
This randomized controlled trial examined the predictive role of ghrelin on food consumption in a controlled setting. Participants underwent four test days with varying preload meals to assess how hormonal and…
Prominent 18F-MFBG Uptake in Brown Adipose Tissue in a Pediatric Patient With Pheochromocytoma.
A 10-year-old boy with clinically suspected left adrenal pheochromocytoma was enrolled in a clinical trial. He underwent 18F-MFBG PET/CT for further evaluation, which revealed intense tracer accumulation in the left…
Sterile abscesses during GnRH agonist therapy for central precocious puberty: a case series and literature review.
Two patients undergoing long-acting GnRH agonist therapy for central precocious puberty developed recurrent sterile abscesses at injection sites, leading to pain and reduced treatment efficacy.
Hepatic Safety of Orforglipron in Adults With Obesity or Overweight and/or Type 2 Diabetes: A Pooled Analysis of the Orforglipron Phase 3 Clinical Trials.
This pooled analysis of seven Phase 3 clinical trials evaluated the hepatic safety of orforglipron in 11,220 adults with obesity or type 2 diabetes.
Efficacy and Safety of GLP-1 Receptor Agonists on Combined Cardiovascular and Renal Outcomes in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis.
This systematic review and network meta-analysis evaluated the efficacy and safety of GLP-1 receptor agonists in patients with chronic kidney disease (CKD).
A Four-Week Treatment With Dapagliflozin Is Associated With a Reduction in Insulin-Stimulated Renal Cortical Glucose Uptake: A Post Hoc Analysis From a Pilot Study.
This post hoc analysis from a randomized controlled trial evaluated the effects of dapagliflozin on renal glucose uptake in patients with type 2 diabetes and stable coronary artery disease.
Adjunctive use of glucagon-like peptide-1 receptor agonists after bariatric surgery: updated systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis pooled seven randomized controlled trials (460 participants) comparing GLP-1 receptor agonists with placebo after bariatric surgery; all trials evaluated liraglutide.
Efficacy and hepatotoxicity of Psoralea corylifolia L.: A meta-analysis and machine learning assessment in postmenopausal osteoporosis.
This meta-analysis evaluated the efficacy and hepatotoxicity of Psoralea corylifolia in postmenopausal osteoporosis. It included 23 efficacy studies and 7 toxicity studies, revealing a significant improvement in bone…
Dual Glucagon and GLP-1 Receptor Agonist Survodutide Improves Biomarkers of Beta-Cell Function and Insulin Sensitivity in People With Type 2 Diabetes or Living With Overweight/Obesity.
This post hoc analysis of two phase 2 randomized controlled trials evaluated the effects of survodutide on beta-cell function and insulin sensitivity in 800 participants with type 2 diabetes or overweight/obesity.
Effects of Weight-Loss Interventions on Kidney, Cardiometabolic and Anthropometric Outcomes in Adults With CKD and Overweight or Obesity: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the effects of weight-loss interventions on kidney, cardiometabolic, and anthropometric outcomes in overweight or obese adults with chronic kidney disease (CKD).
Efficacy and Safety of Bariatric Surgery in Acquired Hypothalamic Obesity: A Systematic Review and Individual Patient Data Meta-Analysis.
This systematic review and individual patient data meta-analysis evaluated the efficacy and safety of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) in adults with acquired hypothalamic obesity (HO).
Impact of weight loss and reduction of ultra-processed foods on liver fat content in MASLD: A randomized controlled trial.
This randomized controlled trial investigated the effects of different dietary strategies on liver fat content in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
Identification and functional characterization of a novel mutation in the NEUROD1 gene in a Chinese family with maturity-onset diabetes of the young.
Few families with maturity-onset diabetes of the young (MODY) caused by neurogenic differentiation factor 1 (NEUROD1) mutations have been identified.
Comparative bioavailability of sublingual vs. oral levothyroxine in patients with post-thyroidectomy hypothyroidism: A single-dose pilot study.
This randomized controlled trial assessed the bioavailability of sublingual versus oral levothyroxine in 15 post-thyroidectomy hypothyroid patients.
Safety and effectiveness of setmelanotide in young patients with severe obesity due to craniopharyngioma: a real world monocentric experience.
Three young adults with hypothalamic obesity following surgery for craniopharyngioma were treated with setmelanotide. While one patient experienced continued weight gain and discontinued treatment, the other two showed…
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