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1821 articles
September 202624
An integrated lifestyle intervention for mitigation of adverse effects associated with androgen deprivation therapy for prostate cancer (STAMINA): a multicentre, randomised trial.
The STAMINA trial, a multicentre, randomised study, evaluated a lifestyle intervention for men undergoing androgen deprivation therapy (ADT) for prostate cancer.
Posttherapy [ 18 F]FDOPA PET Findings in an Anaplastic Pleomorphic Xanthoastrocytoma With a BRAF V600E Mutation.
A 10-year-old boy with a left temporal anaplastic pleomorphic xanthoastrocytoma (APXA) carrying a BRAF V600E mutation presented with generalized tonic-clonic seizures occurring 3–4 times weekly.
Unexpected ¹⁸F-DOPA Uptake in Pediatric Posterior Mediastinal Ewing Sarcoma: A Diagnostic Pitfall in Pediatric Oncology.
A pediatric patient with posterior mediastinal Ewing sarcoma had an unexpected finding on ¹⁸F-DOPA PET/CT: the tumor showed tracer uptake.
Peritoneal Desmoplastic Small Round Cell Tumor on FDG PET/CT.
A 21-year-old man presented with intermittent abdominal pain and distension. Contrast-enhanced CT and 18F-FDG PET/CT showed diffuse peritoneal thickening and multiple hypermetabolic masses, prompting concern for…
Goal-directed nutritional support in preserving muscle mass and optimising recovery in treatment of oesophageal cancer: results of a prospective non-randomised cluster trial.
This prospective non-randomised cluster trial evaluated the impact of a goal-directed nutritional support protocol (GDNS) on muscle mass and survival in adults with oesophageal cancer undergoing neoadjuvant…
BRAF V600E-mutated marginal zone lymphoma may exhibit features that partially overlap with hairy cell leukemia.
This report describes two cases of BRAF-mutated marginal zone lymphoma (MZL), including a nodal MZL (NMZL) with a BRAF V600E mutation that exhibited partial morphologic and immunophenotypic overlap with hairy cell…
Exercise for the mitigation of cancer therapy-related cardiac dysfunction in breast cancer patients treated with anthracyclines: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the impact of long-term exercise on cancer therapy-related cardiac dysfunction (CTRCD) in breast cancer patients treated with anthracyclines.
Prevalence of Claudin 18.2 Expression in Gastric and Gastroesophageal Junction Adenocarcinoma: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the prevalence of CLDN18.2 expression in gastric and gastroesophageal junction adenocarcinoma across 22 studies involving 12,173 patients.
Sodium-glucose cotransporter-2 inhibitors and gastrointestinal neoplasm risk in type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the association between sodium-glucose cotransporter 2 (SGLT2) inhibitors and gastrointestinal neoplasm risk in patients with type 2 diabetes mellitus (T2DM).
Comparative efficacy and safety of pharmacokinetically guided and body surface area-based 5-fluorouracil dosing in colorectal cancer: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of pharmacokinetically guided versus body surface area (BSA)-based dosing of 5-fluorouracil (5-FU) in colorectal cancer.
Daraxonrasib for Previously Treated RAS -Mutant Non-Small-Cell Lung Cancer.
This phase 1-2 multicenter trial evaluated the safety and efficacy of daraxonrasib in 136 patients with previously treated RAS-mutant non-small-cell lung cancer (NSCLC).
Azacitidine-Venetoclax or Induction Chemotherapy for Acute Myeloid Leukemia.
This phase 2 randomized trial compared azacitidine plus venetoclax to induction chemotherapy in 172 previously untreated adults with acute myeloid leukemia (AML) eligible for induction.
Safety and Clinical Outcomes of a First-in-Human Trial of Point-of-Care Manufactured Trispecific CAR T Cells Targeting CD19, CD20, and CD22.
This phase I clinical trial evaluated the safety and efficacy of trispecific CAR T cells targeting CD19, CD20, and CD22 in 16 patients with relapsed/refractory B-cell malignancies.
A novel triple-knockout allogeneic BCMA CAR T-cell therapy (CT0590) for multiple myeloma: preclinical and phase 1 study.
This phase 1 clinical trial evaluated a novel allogeneic BCMA CAR T-cell therapy (CT0590) in 5 patients with relapsed and refractory multiple myeloma or primary plasma cell leukemia.
Arlocabtagene autoleucel: a GPRC5D-targeted CAR T-cell therapy for heavily pretreated relapsed/refractory multiple myeloma.
This phase 1 multicenter trial evaluated arlocabtagene autoleucel (arlo-cel), a CAR T-cell therapy targeting GPRC5D, in 84 adults with heavily pretreated relapsed/refractory multiple myeloma.
Solitary Flat Bone Metastasis of Follicular Thyroid Carcinoma: Complete Molecular and Partial Structural Response After 2 131 I Therapies.
A patient with follicular thyroid carcinoma presented with a solitary metastasis in the right iliac bone, which remained structurally unchanged after two high-dose 131 I therapies.
Value of shear wave elastography in evaluating response to neoadjuvant chemotherapy in breast cancer: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness of shear wave elastography in assessing the pathological response to neoadjuvant chemotherapy in breast cancer patients.
'Posterior (SMA-first) Approach' Versus 'Standard Approach' in Terms of Resection Margin and Long-Term Survival After Pancreaticoduodenectomy for Periampullary and Pancreatic Carcinoma: A Randomized Trial.
This randomized controlled trial compared the SMA-first approach to the standard approach in pancreaticoduodenectomy for periampullary cancer.
Three dimensional printed patient-specific PEEK versus titanium mesh cage for anterior column reconstruction after spondylectomy for spinal tumours: a prospective controlled cohort study.
This prospective controlled cohort study compared subsidence rates at 12 months following vertebral body replacement (VBR) using 3D-printed patient-specific PEEK implants versus titanium mesh cages in adults with…
Germline multigene panel testing for colorectal cancer: a systematic review and meta-analysis.
This systematic review and random-effects meta-analysis assessed germline multigene panel testing in unselected patients with colorectal cancer, pooling evidence from 21 eligible studies.
Molecularly Guided Therapy Versus Continued Chemotherapy in Unfavorable Cancer of Unknown Primary: Updated Efficacy and Safety From the Randomized, Phase II CUPISCO Study.
This updated analysis of the multicenter, randomized phase II CUPISCO trial compared molecularly guided therapy (MGT), selected after comprehensive genomic profiling, with continued platinum-based chemotherapy in…
Effects of erector spinae plane block on postoperative pain in patients undergoing implant-based breast reconstruction for breast cancer: a randomized controlled trial.
This randomized controlled trial evaluated the impact of a single-shot T5 erector spinae plane block (ESPB) on postoperative pain in 100 adults undergoing implant-based breast reconstruction.
Bifidobacterium animalis subsp. lactis V9 overcomes CYFRA 21-1-linked immunochemotherapy resistance in NSCLC via microbial metabolites.
This randomized controlled trial investigated the effects of Bifidobacterium animalis subsp. lactis V9 on immunochemotherapy resistance in patients with advanced non-small cell lung cancer (NSCLC) linked to elevated…
A systematic review and network meta-analysis of first-line EGFR-TKI-based combination strategies for EGFR-mutant non-small cell lung cancer with brain metastases.
This systematic review and network meta-analysis evaluated the efficacy and safety of first-line EGFR-TKI-based combination strategies in patients with EGFR-mutant non-small cell lung cancer and brain metastases.
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