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TQB2618 plus Penpulimab, Alone or in Combination with Chemotherapy, for Recurrent or Metastatic Nasopharyngeal Carcinoma: A Multicenter, Two-Cohort, Phase II Trial.

This Phase II multicenter trial evaluated the efficacy and safety of TQB2618 plus penpulimab in recurrent/metastatic nasopharyngeal carcinoma.

A Phase I and Biodistribution Study of Ifabotuzumab, a Humanized Agonistic EphA3-Targeted Antibody, in Patients with Recurrent Glioblastoma.

This Phase I multicenter study evaluated the safety and biodistribution of ifabotuzumab, an EphA3-targeted antibody, in 12 adults with recurrent glioblastoma.

A Phase Ib/IIa Study of Fostrox in Combination with Lenvatinib as Second-line Therapy in Patients with Advanced Hepatocellular Carcinoma.

This multicenter, single-arm Phase Ib/IIa study evaluated the combination of fostroxacitabine bralpamide (fostrox) and lenvatinib in 21 patients with advanced hepatocellular carcinoma (HCC) who progressed on prior…

Phase I Trial of Intravenous VCN-01 Oncolytic Adenovirus and Durvalumab in Patients with Head and Neck Metastatic Squamous Cell Carcinoma Refractory to Immunotherapy.

This Phase I trial evaluated the safety and efficacy of intravenous VCN-01 oncolytic adenovirus combined with durvalumab in patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) refractory to…

Phase Ib Trial of Bavdegalutamide (ARV-110) in Combination with Abiraterone for Metastatic Prostate Cancer.

This phase Ib trial assessed the safety and pharmacokinetics of bavdegalutamide combined with abiraterone in 45 patients with metastatic prostate cancer (mPC) experiencing PSA progression.

Targeting Fibroblast Activation Protein with [177Lu]Lu-FAP-2286 in Patients with Advanced Solid Tumors in the Phase I LuMIERE Trial.

The Phase I LuMIERE trial evaluated the safety of [177Lu]Lu-FAP-2286 in 27 heavily pretreated patients with advanced solid tumors.

Sensitivity to Endocrine Therapy Index Predicts Benefit from Weekly Adjuvant Paclitaxel for Hormone Receptor-Positive Breast Cancer in the GEICAM/9906 Trial.

This randomized controlled trial evaluated the predictive value of the sensitivity to endocrine therapy (SETER/PR) index for the benefit of weekly adjuvant paclitaxel in hormone receptor-positive breast cancer.

PiggyBac-Engineered Membrane-Bound IL7 TILs Combined with Anti-PD-1 Antibody Demonstrates Efficacy in Recurrent Ovarian Cancer: A First-in-Human Phase I Trial.

This first-in-human phase I trial evaluated the safety and efficacy of GC203, a genetically modified tumor-infiltrating lymphocyte (TIL) product, in 18 heavily pretreated patients with recurrent ovarian cancer.

Cancer DiscovSep 1, 2026Read summary

Intratumoral Sotigalimab with Pembrolizumab Induces Rapid Activation of Antigen-Presenting Cells and Drives Antitumor Responses in Non-injected Tumors in Metastatic Melanoma: A Phase I/II Study.

This phase I/II clinical trial evaluated intratumoral sotigalimab, a CD40 agonist, plus pembrolizumab in 32 patients with immune-checkpoint-blocker-naïve metastatic melanoma.

Case ReportPulmonology

A Rare Case of Sporadic Lymphangioleiomyomatosis in a Male Patient Diagnosed Following Pneumothorax.

A 51-year-old male presented with pneumothorax, leading to the diagnosis of sporadic lymphangioleiomyomatosis (LAM). High-resolution CT scans revealed multiple thin-walled cysts in both lungs.

J Thorac ImagingSep 1, 2026Read case

Case ReportNephrology

A rare case of renal cancer with PLA2R-positive membranous nephropathy and AL amyloidosis: Insights into mechanisms and treatment.

An elderly male presented with nephrotic syndrome and a right renal mass, leading to a nephrectomy. Pathological examination confirmed renal clear cell carcinoma, alongside PLA2R-positive membranous nephropathy and AL…

Clin NephrolSep 1, 2026Read case

Genomic Profiling of Epidermal Growth Factor Receptor Mutation-Positive Non-Small Cell Lung Cancer after Progression on First-line Osimertinib: Phase II ORCHARD Study.

The ORCHARD Phase II study investigated the genomic profiles of patients with EGFR mutation-positive non-small cell lung cancer (NSCLC) after progression on first-line osimertinib.

Retin Cases Brief RepSep 1, 2026Read case

Case ReportOphthalmology

FULMINANT CLOSTRIDIUM SEPTICUM ENDOGENOUS ENDOPHTHALMITIS PRESENTING WITH INTRAOCULAR GAS IN A PATIENT WITH METASTATIC ENDOMETRIAL CANCER.

A 52-year-old woman with metastatic endometrial cancer experienced sudden vision loss in her left eye following dizziness and fever.

Case ReportOphthalmology

SURGICAL APPROACH TO SUBRETINAL WASHOUT BIOPSY FOR PRIMARY VITREORETINAL LYMPHOMA.

A patient presented with primary vitreoretinal lymphoma (PVRL) that mimicked vitritis and included subretinal lesions. A combined approach of anterior chamber tap, dry vitreous biopsy, and subretinal washout was…

Retin Cases Brief RepSep 1, 2026Read case

Case ReportGastroenterology

Immune Checkpoint Inhibitor-Induced Pancreatitis.

A case report described five female patients who developed immune checkpoint inhibitor-induced pancreatitis (ICIPI) after receiving combination ICI therapy.

United European Gastroenterol JSep 1, 2026Read case

Case ReportMedical Genetics

Tandem Double Inversion Resolves the Structural Paradox Underlying Recurrent KAT6A::NCOA2 Fusion in Acute Myeloid Leukemia.

A case of acute myeloid leukemia (AML) presented with the rare KAT6A::NCOA2 fusion, typically associated with inv(8)(p11q13). Genomic profiling revealed an unexpected MTFR1::KAT6A rearrangement.

Genes Chromosomes CancerSep 1, 2026Read case

Case ReportOncology (Medical)

Immune Checkpoint Inhibitors in Relapsed/Refractory Anaplastic Large Cell Lymphoma (ALCL): A Case Report and Review of the Literature.

A patient with relapsed/refractory anaplastic large cell lymphoma (ALCL) achieved sustained complete remission following treatment with a PD-1 inhibitor after multiple prior therapies.

Cancer Rep (Hoboken)Sep 1, 2026Read case

Cancer Rep (Hoboken)Sep 1, 2026Read summary

First-Line PD-1 Inhibitor-Based Therapy for Advanced or Metastatic Esophageal Squamous Cell Carcinoma: A Revised Systematic Review and Meta-Analysis of Phase III Trials.

This systematic review and meta-analysis evaluated phase III trials comparing first-line PD-1 inhibitor-based therapy to chemotherapy in advanced esophageal squamous cell carcinoma (ESCC).

J Natl Cancer InstSep 1, 2026Read summary

Electroacupuncture improves cognitive function and neuropsychiatric symptoms in breast cancer survivors: a pilot randomized controlled trial.

This pilot randomized controlled trial evaluated the effects of electroacupuncture (EA) on cognitive function and neuropsychiatric symptoms in breast cancer survivors.

J Natl Cancer InstSep 1, 2026Read summary

Impact of beta-blockers on prognostic outcomes in solid cancers: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the impact of beta-blocker use on survival outcomes in patients with solid cancers, analyzing data from 603,827 patients across 84 studies.

Clinical ResearchHematologyOpen access

XY0206 targets FLT3-dependent resistance states in acute myeloid leukemia.

This phase I/II clinical trial evaluated XY0206 monotherapy in patients with relapsed or refractory acute myeloid leukemia (AML), alongside laboratory and animal studies of its FLT3-directed activity.

J Clin InvestSep 1, 2026Read summary

August 20263

Front ImmunolAug 31, 2026Read summary

Efficacy and safety of bispecific antibodies versus other antitumor therapies in solid tumors: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the efficacy and safety of bispecific antibodies (BsAbs) in treating solid tumors, involving 3,505 patients across 9 studies.