Trending archive
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93 articles
June 202619
A novel JAK1 mutation identified in a patient with severe atopic dermatitis phenotype: Mechanistic insights and IL-4Rα targeted therapy.
A child with early-onset severe atopic dermatitis presented with eosinophilia, elevated IgE, and growth retardation. Genetic analysis identified a novel JAK1 gain-of-function mutation (p.L783F).
Usability and Acceptance of Autoinjector and Prefilled Syringe Devices by Patients with Generalized Myasthenia Gravis in a Human Factors Study.
This randomized controlled trial evaluated the usability and acceptance of a prefilled syringe with needle safety device (PFS-SD) and an autoinjector (AI) among patients with generalized myasthenia gravis (gMG).
Dupilumab outcomes in pediatric asthma by early eosinophil status: Post hoc analysis of VOYAGE/EXCURSION.
This post hoc analysis of the randomized controlled trials VOYAGE and EXCURSION evaluated the long-term efficacy and safety of dupilumab in children aged 6 to 11 with type 2 asthma, focusing on those with early…
Alpha-Gal Syndrome-A Case Series of Successful Transcatheter Mammalian-Derived Aortic Valve Replacements.
Three patients with documented Alpha-gal syndrome (AGS) successfully underwent transcatheter aortic valve replacement (TAVR) using bovine or porcine-derived bioprosthetic valves.
A Novel Device to Improve the Tolerability of Intranasal Corticosteroid Sprays for Allergic Rhinitis and Postoperative Chronic Rhinosinusitis: A Crossover Trial.
This randomized controlled trial evaluated a novel nasal adaptor for metered-dose inhalers (MDIs) in patients with allergic rhinitis (AR) and postoperative chronic rhinosinusitis (CRS).
Effects of positive psychotherapy on anxiety and quality of life in chronic Urticaria.
This randomized controlled trial examined the effects of positive psychotherapy on anxiety and quality of life in 66 patients with Chronic Spontaneous Urticaria (CSU).
Diverse Trial Designs, Populations, and Outcomes: A Systematic Literature Review of Trials for the Treatment of Hereditary Angioedema Attacks.
This systematic literature review evaluated 12 phase 2-3 randomized clinical trials for on-demand treatments of hereditary angioedema (HAE) attacks.
Dupilumab Efficacy in Children With Uncontrolled, Moderate-to-Severe, Type 2 Asthma by Allergen Sensitization Level.
This post hoc analysis of the multicenter, randomized VOYAGE trial examined dupilumab by allergen sensitization status in children aged 6 to 11 years with uncontrolled, moderate-to-severe type 2 asthma.
Pediatric Neuroinflammatory and Neuropsychiatric Syndromes Associated with Dupilumab Treatment for Atopic Dermatitis.
Four children treated with dupilumab for atopic dermatitis developed neuroinflammatory syndromes characterized by behavioral changes, language impairment, and neurodiagnostic abnormalities within 2-6 months of starting…
Inhaled Salbutamol Versus Placebo for the Treatment of Acute IgE-Mediated Abdominal Pain From Allergic Food Reactions (INSPIRE Trial): A Double-Blind Randomized Trial.
The INSPIRE trial evaluated inhaled salbutamol's efficacy in treating moderate-to-severe IgE-mediated abdominal pain in patients aged 6 to 55 years.
The Effect of an Augmented Reality Game on Pain and Fear Levels and Care Satisfaction During Allergy Testing in Children Aged 4-12: A Randomized Controlled Study.
This randomized controlled trial evaluated the impact of an augmented reality game on pain, fear, and care satisfaction in 66 children aged 4-12 undergoing allergy skin prick tests.
Safety and Early Immune Dynamics Following First Dose of the MMR Vaccine in a Toddler Treated With a JAK Inhibitor.
A toddler receiving baricitinib was accidentally given the live measles-mumps-rubella (MMR) vaccine. No vaccine-related adverse events were reported.
Remibrutinib impact on disease control, sleep, and quality of life: Analysis of phase 3 REMIX-1/2.
This phase 3 randomized controlled trial evaluated the effects of remibrutinib on disease control, sleep, and quality of life in adults with chronic spontaneous urticaria (CSU) who were symptomatic despite antihistamine…
Dupilumab Extended Interval Dosing in Chronic Rhinosinusitis With Nasal Polyps: A Systematic Review and Meta-analysis.
This systematic review and meta-analysis evaluated the effects of extending dupilumab dosing intervals beyond the standard every-two-weeks regimen in adults with chronic rhinosinusitis with nasal polyps.
Effect of depemokimab on asthma control and clinical outcomes: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effects of depemokimab on asthma control and clinical outcomes in patients with eosinophilic asthma.
Lonvoguran Ziclumeran - In Vivo CRISPR Gene Editing in Hereditary Angioedema.
This phase 3, multicenter, double-blind randomized trial evaluated a single intravenous infusion of lonvoguran ziclumeran, an investigational in vivo CRISPR gene-editing treatment, in patients aged 16 years or older…
Comparative Efficacy and Safety of Topical Bepotastine Besilate 1.5% Versus Sodium Cromoglycate 4% in Chronic Allergic Conjunctivitis: A Prospective Study.
This randomized controlled trial compared the efficacy and safety of bepotastine besilate 1.5% and sodium cromoglycate 4% in 100 adults with chronic allergic conjunctivitis.
Aerobic training versus behavioural intervention to increase physical activity on clinical control of people with moderate-to-severe asthma: A randomised clinical trial.
This randomized clinical trial compared aerobic training (AT) and behavioral intervention (BI) in improving clinical control among physically inactive adults with moderate to severe asthma.
Obexelimab for the Treatment of IgG4-Related Disease.
This phase 3 randomized controlled trial evaluated obexelimab in 194 patients with active IgG4-related disease. The study found that obexelimab significantly prolonged the time to the first disease flare requiring…
May 20265
Phase Ib/II Study of Preliminary Efficacy, Safety and Pharmacodynamics of MG-K10, a Humanised Monoclonal Antibody Targeting IL-4Rα, in Adult Chinese Patients With Asthma.
This Phase Ib/II randomized controlled trial evaluated the efficacy, safety, and pharmacodynamics of MG-K10, a monoclonal antibody targeting IL-4Rα, in Chinese adults with moderate-to-severe asthma.
Exploratory pilot trial of a multicomponent immunonutritional supplement in children with allergic asthma and rhinitis: The INAPRA study.
The INAPRA study was a multicenter, randomized, double-blind, placebo-controlled pilot trial investigating a multicomponent immunonutritional supplement in 40 children aged 5-12 with allergic asthma and rhinitis.
Ginger-based formulations for allergic rhinitis disease: a systematic review and meta-analysis of experimental studies in animals and humans.
This systematic review and meta-analysis evaluated the efficacy of ginger-based formulations for allergic rhinitis in both animal and human studies.
Improved asthma outcomes with dupilumab plus medium-dose inhaled corticosteroids vs placebo plus high-dose inhaled corticosteroids.
This phase III randomized controlled trial evaluated the effects of adding dupilumab to medium-dose inhaled corticosteroids (ICS) versus high-dose ICS alone in patients with uncontrolled moderate-to-severe asthma.
Depemokimab reduces asthma exacerbations similarly to other biologics.
This systematic review and network meta-analysis evaluated the efficacy and safety of depemokimab compared to other biologics in patients with severe type 2 asthma.
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