Trending archive
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1821 articles
August 202624
What is the prognostic significance of positive lymph nodes at the circumferential resection margin in rectal cancer: a systematic review.
This systematic review examined whether rectal cancer involving the circumferential resection margin (CRM) through metastatic lymph nodes carries the same prognosis as CRM involvement from direct tumor extension.
Effect of adding umbilical cord blood derived stem cells to haploidentical stem cell transplant (haplo-cord) on post-transplant survival and graft-versus-host disease in patients with hematological malignancies: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the impact of adding umbilical cord blood-derived stem cells to haploidentical stem cell transplantation (haplo-cord) in patients with hematological malignancies.
A phase I clinical study of the safety, tolerability, pharmacokinetics and pharmacodynamics of SHR-2106, an anti-CD40 antibody, following single intravenous or subcutaneous administration in healthy participants.
This Phase I randomized controlled trial evaluated the safety, pharmacokinetics, and pharmacodynamics of SHR-2106, an anti-CD40 antibody, in 51 healthy adults.
Lenvatinib plus pembrolizumab for the treatment of patients with non-BRAF mutated anaplastic thyroid cancer: A single center, phase 2 clinical trial.
This phase 2 clinical trial evaluated the efficacy of lenvatinib plus pembrolizumab in 25 patients with non-BRAF mutated anaplastic thyroid cancer (ATC).
Polyphyllin I in malignant tumors: molecular mechanisms and advances.
This systematic review examines Polyphyllin I (PPI), a natural product from Rhizoma Paridis, focusing on its antitumor mechanisms and druggability.
Extended Versus Non-Extended Lymphadenectomy in Radical Cystectomy for Bladder Cancer: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the outcomes of extended versus non-extended lymphadenectomy during radical cystectomy for bladder cancer in 5671 patients across 15 studies.
Image-Guided Thyroid Ablation versus Surgery for T1N0M0 Papillary Thyroid Carcinoma: A Consensus-Aligned Systematic Review and Meta-Analysis.
This systematic review and meta-analysis compared image-guided thyroid ablation (IGTA) with surgery for T1N0M0 papillary thyroid carcinoma (PTC).
The associations between household food insecurity and cancer: A comprehensive systematic review and meta-analysis of observational studies among adults.
This systematic review and meta-analysis examined observational evidence on household food insecurity (HFI) and cancer-related outcomes in adults.
SHR-2004, a Humanized Monoclonal Antibody Targeting Factor XI, for Preventing Venous Thromboembolism After Ovarian Cancer Surgery: A Randomized, Active-Controlled Phase 2 Study.
This multicenter, open-label, randomized Phase 2 trial compared the factor XI-targeting antibody SHR-2004 with enoxaparin followed by rivaroxaban for postoperative venous thromboembolism (VTE) prevention in patients…
Acute development of EBV+ T-cell lymphoproliferative disorder after treatment with rituximab for follicular lymphoma.
An elderly patient developed an EBV-positive T-cell lymphoproliferative disorder (LPD) following treatment with rituximab for follicular lymphoma.
Induction Paclitaxel-Cisplatin-Capecitabine for Nasopharyngeal Carcinoma.
This multicenter, randomized controlled trial evaluated the efficacy of induction chemotherapy with paclitaxel, cisplatin, and capecitabine (TPC) versus cisplatin and fluorouracil (PF) in patients with high-risk…
Consolidation Therapy Based on Mutation Clearance in Acute Myeloid Leukemia.
This phase II multicenter trial evaluated the impact of leukemia-associated mutation (LAM) clearance on relapse-free survival (RFS) in 100 patients aged 18-60 with intermediate-risk acute myeloid leukemia (AML) in first…
Primary ovarian non-small cell neuroendocrine carcinoma in an adolescent: The youngest case reported to date.
A 15-year-old girl presented with acute abdominal pain and a large cystic-solid abdominopelvic mass. Emergency fertility-sparing cytoreductive surgery confirmed the diagnosis of primary ovarian non-small cell…
HPV circulating tumor DNA as a potential prognostic and predictive biomarker in head and neck squamous cell carcinoma: a systematic review.
This systematic review evaluated the prognostic and predictive value of human papillomavirus circulating tumor DNA (HPVctDNA) in head and neck squamous cell carcinoma (HNSCC), analyzing 60 studies with 8,234 patients.
Becotatug Vedotin Combined With Pucotenlimab in Platinum- and Immunotherapy-Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma.
This phase I/II clinical trial evaluated the combination of becotatug vedotin (BV) and pucotenlimab in patients with platinum- and immunotherapy-resistant recurrent or metastatic nasopharyngeal carcinoma (R/M NPC).
On-demand transarterial chemoembolisation combined with atezolizumab and bevacizumab in patients with untreated hepatocellular carcinoma (TALENTACE): a multicentre, randomised, open-label, phase 3 trial.
TALENTACE was a multicentre, open-label, randomised phase 3 trial comparing on-demand transarterial chemoembolisation (TACE) plus atezolizumab and bevacizumab with TACE alone in 342 patients with untreated, unresectable…
Predicting TERT mutation in glioma patients using MRI-derived radiomics; A systematic review and meta-analysis.
This systematic review and meta-analysis assessed MRI-derived radiomics models for predicting TERT promoter mutation status in patients with glioma.
Radiation Fibrosis Syndrome: A Case-Based Approach to Identification, Evaluation, and Treatment.
A patient developed Radiation Fibrosis Syndrome (RFS) following radiation therapy, presenting with multi-system involvement including neural and visceral structures.
Visualization of Gerota Fascia Involved With Metastatic Melanoma on FDG PET/CT.
A 67-year-old man with melanoma underwent FDG PET/CT, which showed FDG-avid curvilinear soft tissue anterior, lateral, and posterior to the left kidney.
Chemoradiotherapy versus short-course radiotherapy for response-adapted organ preservation in early-stage and intermediate-stage rectal cancer (STAR-TREC): 12-month results of an international, multicentre, open-label, parallel-group, randomised, phase 2/3 trial.
The STAR-TREC trial evaluated long-course chemoradiotherapy (LCCRT) versus short-course radiotherapy (SCRT) for organ preservation in early-stage and intermediate-stage rectal cancer.
Older adults with resectable gastric cancer undergoing perioperative chemotherapy or preoperative chemoradiotherapy plus perioperative chemotherapy: A secondary analysis of the AGITG TOPGEAR phase III trial.
This secondary analysis of the AGITG TOPGEAR phase III trial evaluated older adults (≥70 years) with resectable gastric cancer undergoing perioperative chemotherapy or chemoradiotherapy.
First-line pyrotinib plus apatinib in advanced non-small cell lung cancer harboring HER2 mutations or amplification: a phase II trial.
This phase II trial evaluated the efficacy of pyrotinib plus apatinib in treatment-naïve patients with advanced non-small cell lung cancer (NSCLC) harboring HER2 mutations or amplification.
Prognostic value of CD103+ tumor-infiltrating lymphocytes in bladder cancer: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the prognostic significance of CD103+ tumor-infiltrating lymphocytes in bladder cancer, focusing on muscle-invasive and metastatic cases.
Antitumor activity of scorpion venom-derived peptides: A meta-analysis of preclinical studies.
This meta-analysis evaluated the antitumor effects of scorpion venom-derived peptides (SVDPs) across various cancer types in preclinical studies.
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